EyeLink fMRI / MEG Publications
All EyeLink fMRI and MEG research publications (with concurrent eye tracking) up until 2023 (with some early 2024s) are listed below by year. You can search the publications using keywords such as Visual Cortex, Neural Plasticity, MEG, etc. You can also search for individual author names. If we missed any EyeLink fMRI or MEG articles, please email us!
2023 |
Evelyn Milburn; Michael Walsh Dickey; Tessa Warren; Rebecca Hayes Increased reliance on world knowledge during language comprehension in healthy aging: evidence from verb-argument prediction Journal Article In: Aging, Neuropsychology, and Cognition, vol. 30, no. 1, pp. 1–33, 2023. @article{Milburn2023, Cognitive aging negatively impacts language comprehension performance. However, there is evidence that older adults skillfully use linguistic context and their crystallized world knowledge to offset age-related changes that negatively impact comprehension. Two visual-world paradigm experiments examined how aging changes verb-argument prediction, a comprehension process that relies on world knowledge but has rarely been examined in the cognitive-aging literature. Older adults did not differ from younger adults in their activation of an upcoming likely verb argument, particularly when cued by a semantically-rich agent+verb combination (Experiment 1). However, older adults showed elevated activation of previously-mentioned agents (Experiment 1) and of unlikely but verb-congruent referents (Experiment 2). This is novel evidence that older adults exploit semantic context and world knowledge during comprehension to successfully activate upcoming referents. However, older adults also show elevated activation of irrelevant information, consistent with previous findings demonstrating that older adults may experience greater proactive interference and competition from task-irrelevant information. |
Lea Moersdorf; Alexandra M. Freund; Moritz M. Daum What do you focus on? An investigation of goal focus from childhood to old age Journal Article In: Psychological Research, vol. 87, no. 7, pp. 2120–2137, 2023. @article{Moersdorf2023, Goals constitute an important construct in developmental psychology. They represent a central way in which individuals shape their development. Here, we present two studies on age-related differences in one important goal dimension, goal focus, that is, the relative salience of the means and ends of goal pursuit. Extant studies on age-related differences in adults suggest a shift from focusing on the ends to focusing on the means across adulthood. The current studies aimed to expand this research to encompass the entire lifespan including childhood. The first cross-sectional study included participants spanning from early childhood into old age (N = 312, age range: 3–83 years) and used a multimethodological approach comprising eye tracking, behavioral, and verbal measures of goal focus. The second study investigated the verbal measures of the first study in more detail in an adult sample (N = 1550, age range: 17–88 years). Overall, the results do not show a clear pattern, making them difficult to interpret. There was little convergence of the measures, pointing to the difficulties in assessing a construct such as goal focus across a large range of age groups differing in social-cognitive and verbal skills. |
Padraic Monaghan; Seamus Donnelly; Katie Alcock; Amy Bidgood; Kate Cain; Samantha Durrant; Rebecca L. A. Frost; Lana S. Jago; Michelle S. Peter; Julian M. Pine; Heather Turnbull; Caroline F. Rowland Learning to generalise but not segment an artificial language at 17 months predicts children's language skills 3 years later Journal Article In: Cognitive Psychology, vol. 147, pp. 1–13, 2023. @article{Monaghan2023, We investigated whether learning an artificial language at 17 months was predictive of children's natural language vocabulary and grammar skills at 54 months. Children at 17 months listened to an artificial language containing non-adjacent dependencies, and were then tested on their learning to segment and to generalise the structure of the language. At 54 months, children were then tested on a range of standardised natural language tasks that assessed receptive and expressive vocabulary and grammar. A structural equation model demonstrated that learning the artificial language generalisation at 17 months predicted language abilities – a composite of vocabulary and grammar skills – at 54 months, whereas artificial language segmentation at 17 months did not predict language abilities at this age. Artificial language learning tasks – especially those that probe grammar learning – provide a valuable tool for uncovering the mechanisms driving children's early language development. |
Sebastián Moyano; Josué Rico-Picó; Ángela Conejero; Ángela Hoyo; María de los Ángeles Ballesteros-Duperón; M. Rosario Rueda Influence of the environment on the early development of attentional control Journal Article In: Infant Behavior and Development, vol. 71, pp. 1–17, 2023. @article{Moyano2023, The control of visual attention is key to learning and has a foundational role in the development of self-regulated behavior. Basic attention control skills emerge early in life and show a protracted development along childhood. Prior research suggests that attentional development is influenced by environmental factors in early and late childhood. Although, much less information is available about the impact of the early environment on emerging endogenous attention skills during infancy. In the current study we aimed to test the impact of parental socioeconomic status (SES) and home environment (chaos) in the emerging control of orienting in a sample of typically-developing infants. A group of 142 (73 female) 6-month-old infants were longitudinally tested at 6, 9 (n = 122; 60 female) and 16–18 (n = 91; 50 female) months of age using the gap-overlap paradigm. Median saccade latency (mdSL) and disengagement failure (DF) were computed as dependent variables for both overlap and gap conditions. Also, composite scores for a Disengagement Cost Index (DCI) and Disengagement Failure Index (DFI) were computed considering mdSL and DF of each condition, respectively. Families reported SES and chaos in the first and last follow-up sessions. Using Linear Mixed Models with Maximum Likelihood estimation (ML) we found a longitudinal decrease in mdSL in the gap but not in the overlap condition, while DF decreased with age independently of the experimental condition. Concerning early environmental factors, an SES index, parental occupation and chaos at 6 months were found to show a negative correlation with DFI at 16–18 months, although in the former case it was only marginally significant. Hierarchical regression models implementing ML showed that both SES and chaos at 6 months significantly predicted a lower DFI at 16–18 months. Results show a longitudinal progression of endogenous orienting between infancy and toddlerhood. With age, an increased endogenous control of orienting is displayed in contexts where visual disengagement is facilitated. Visual orienting involving attention disengagement in contexts of visual competition do not show changes with age. Moreover, these attentional mechanisms of endogenous control seem to be modulated by early experiences of the individual with the environment. |
Ryan M. O'Leary; Nicole M. Amichetti; Zoe Brown; Alexander J. Kinney; Arthur Wingfield Congruent prosody reduces cognitive effort in memory for spoken sentences: A pupillometric study with young and older adults Journal Article In: Experimental Aging Research, pp. 1–24, 2023. @article{OLeary2023, Background: In spite of declines in working memory and other processes, older adults generally maintain good ability to understand and remember spoken sentences. In part this is due to preserved knowledge of linguistic rules and their implementation. Largely overlooked, however, is the support older adults may gain from the presence of sentence prosody (pitch contour, lexical stress, intra-and inter-word timing) as an aid to detecting the structure of a heard sentence. Methods: Twenty-four young and 24 older adults recalled recorded sentences in which the sentence prosody corresponded to the clausal structure of the sentence, when the prosody was in conflict with this structure, or when there was reduced prosody uninformative with regard to the clausal structure. Pupil size was concurrently recorded as a measure of processing effort. Results: Both young and older adults' recall accuracy was superior for sentences heard with supportive prosody than for sentences with uninformative prosody or for sentences in which the prosodic marking and causal structure were in conflict. The measurement of pupil dilation suggested that the task was generally more effortful for the older adults, but with both groups showing a similar pattern of effort-reducing effects of supportive prosody. Conclusions: Results demonstrate the influence of prosody on young and older adults' ability to recall accurately multi-clause sentences, and the significant role effective prosody may play in preserving processing effort. |
Henri Olkoniemi; Sohvi Halonen; Penny M. Pexman; Tuomo Häikiö Children's processing of written irony: An eye-tracking study Journal Article In: Cognition, vol. 238, pp. 1–18, 2023. @article{Olkoniemi2023, Ironic language is challenging for many people to understand, and particularly for children. Comprehending irony is considered a major milestone in children's development, as it requires inferring the intentions of the person who is being ironic. However, the theories of irony comprehension generally do not address developmental changes, and there are limited data on children's processing of verbal irony. In the present pre-registered study, we examined, for the first time, how children process and comprehend written irony in comparison to adults. Seventy participants took part in the study (35 10-year-old children and 35 adults). In the experiment, participants read ironic and literal sentences embedded in story contexts while their eye movements were recorded. They also responded to a text memory question and an inference question after each story, and children's levels of reading skills were measured. Results showed that for both children and adults comprehending written irony was more difficult than for literal texts (the “irony effect”) and was more challenging for children than for adults. Moreover, although children showed longer overall reading times than adults, processing of ironic stories was largely similar between children and adults. One group difference was that for children, more accurate irony comprehension was qualified by faster reading times whereas for adults more accurate irony comprehension involved slower reading times. Interestingly, both age groups were able to adapt to task context and improve their irony processing across trials. These results provide new insights about the costs of irony and development of the ability to overcome them. |
Jordan C. Abramowitz; Matthew J. Goupell; Kristina DeRoy Milvae Cochlear–implant simulated signal degradation exacerbates listening effort in older listeners Journal Article In: Ear & Hearing, pp. 1–10, 2023. @article{Abramowitz2023, Objectives: Individuals with cochlear implants (CIs) often report that listening requires high levels of effort. Listening effort can increase with decreasing spectral resolution, which occurs when listening with a CI, and can also increase with age. What is not clear is whether these factors interact; older CI listeners potentially experience even higher listening effort with greater signal degradation than younger CI listeners. This study used pupillometry as a physiological index of listening effort to examine whether age, spectral resolution, and their interaction affect listening effort in a simulation of CI listening. Design: Fifteen younger normal-hearing listeners (ages 18 to 31 years) and 15 older normal-hearing listeners (ages 65 to 75 years) participated in this experiment; they had normal hearing thresholds from 0.25 to 4 kHz. Participants repeated sentences presented in quiet that were either unprocessed or vocoded, simulating CI listening. Stimuli frequency spectra were limited to below 4 kHz (to control for effects of age-related high-frequency hearing loss), and spectral resolution was decreased by decreasing the number of vocoder channels, with 32-, 16-, and 8-channel conditions. Behavioral speech recognition scores and pupil dilation were recorded during this task. In addition, cognitive measures of working memory and processing speed were obtained to examine if individual differences in these measures predicted changes in pupil dilation. Results: For trials where the sentence was recalled correctly, there was a significant interaction between age and spectral resolution, with significantly greater pupil dilation in the older normal-hearing listeners for the 8- and 32-channel vocoded conditions. Cognitive measures did not predict pupil dilation. Conclusions: There was a significant interaction between age and spectral resolution, such that older listeners appear to exert relatively higher listening effort than younger listeners when the signal is highly degraded, with the largest effects observed in the eight-channel condition. The clinical implication is that older listeners may be at higher risk for increased listening effort with a CI. |
Victoria I. Adedeji; Julie A. Kirkby; Martin R. Vasilev; Timothy J. Slattery Children's Reading of Sublexical Units in Years Three to Five: A Combined Analysis of Eye-Movements and Voice Recording Journal Article In: Scientific Studies of Reading, pp. 1–20, 2023. @article{Adedeji2023, Purpose: Children progress from making grapheme–phoneme connections to making grapho-syllabic connections before whole-word connections during reading development (Ehri, 2005a). More is known about the development of grapheme–phoneme connections than is known about grapho-syllabic connections. Therefore, we explored the trajectory of syllable use in English developing readers during oral reading. Method: Fifty-one English-speaking children (mean age: 8.9 years, 55% females, 88% monolinguals) in year groups three, four, and five read aloud sentences with an embedded target word, while their eye movements and voices were recorded. The targets contained six letters and were either one or two syllables. Result: Children in grade five had shorter gaze duration, shorter articulation duration, and larger spatial eye-voice span (EVS) than children in grade four. Children in grades three and four did not significantly differ on these measures. A syllable number effect was found for gaze duration but not for articulation duration and spatial EVS. Interestingly, one-syllable words took longer to process compared to two-syllable words, suggesting that more syllables may not always signify greater processing difficulty. Conclusion: Overall, children are sensitive to sublexical reading units; however, due to sample and stimuli limitations, these findings should be interpreted with caution and further research conducted. |
Srishty Aggarwal; Supratim Ray In: Cerebral Cortex Communications, vol. 4, no. 2, pp. 1–12, 2023. @article{Aggarwal2023, The power spectral density (PSD) of the brain signals is characterized by two distinct features: oscillations, which are represented as distinct “bumps,” and broadband aperiodic activity, that reduces in power with increasing frequency and is characterized by the slope of the power falloff. Recent studies have shown a change in the slope of the aperiodic activity with healthy aging and mental disorders. However, these studies analyzed slopes over a limited frequency range (<100 Hz). To test whether the PSD slope is affected over a wider frequency range with aging and mental disorder, we analyzed the slope till 800 Hz in electroencephalogram data recorded from elderly subjects (>49 years) who were healthy (n = 217) or had mild cognitive impairment (MCI; n = 11) or Alzheimer's Disease (AD; n = 5). Although the slope reduced up to ~ 150 Hz with healthy aging (as shown previously), surprisingly, at higher frequencies (>200 Hz), it increased with age. These results were observed in all electrodes, for both eyes open and eyes closed conditions, and for different reference schemes. However, slopes were not significantly different in MCI/AD subjects compared with healthy controls. Overall, our results constrain the biophysical mechanisms that are reflected in the PSD slopes in healthy and pathological aging. |
Sally Andrews; Aaron Veldre; Roslyn Wong; Lili Yu; Erik D. Reichle How do task demands and aging affect lexical prediction during online reading of natural texts? Journal Article In: Journal of Experimental Psychology: Learning, Memory, and Cognition, vol. 49, no. 3, pp. 407–430, 2023. @article{Andrews2023, Facilitated identification of predictable words during online reading has been attributed to the generation of predictions about upcoming words. But highly predictable words are relatively infrequent in natural texts, raising questions about the utility and ubiquity of anticipatory prediction strategies. This study investigated the contribution of task demands and aging to predictability effects for short natural texts from the Provo corpus. The eye movements of 49 undergraduate students (mean age 21.2) and 46 healthy older adults (mean age 70.8) were recorded while they read these passages in two conditions: (a) reading for meaning to answer occasional comprehension questions; (b) proofreading to detect “transposed letter” lexical errors (e. g., clam instead of calm) in intermixed filler passages. The results suggested that the young adults, but not the older adults, engaged anticipatory prediction strategies to detect semantic errors in the proofreading condition, but neither age group showed any evidence of costs of prediction failures. Rather, both groups showed facilitated reading times for unexpected words that appeared in a high constraint within-sentence position. These findings suggest that predictability effects for natural texts reflect partial, probabilistic expectancies rather than anticipatory prediction of specific words. |
Monica Barbira; Mireille J. Babineaua; Anne-Caroline Fiévét; Anne Christophe; Anne-Caroline Fiéveta; Anne Christophe Rapid infant learning of syntactic–semantic links Journal Article In: Proceedings of the National Academy of Sciences, vol. 120, no. 1, pp. 1–6, 2023. @article{Barbira2023, In the second year of life, infants begin to rapidly acquire the lexicon of their native lan- guage. A key learning mechanism underlying this acceleration is syntactic bootstrapping: the use of hidden cues in grammar to facilitate vocabulary learning. How infants forge the syntactic–semantic links that underlie this mechanism, however, remains specula- tive. A hurdle for theories is identifying computationally light strategies that have high precision within the complexity of the linguistic signal. Here, we presented 20-mo-old infants with novel grammatical elements in a complex natural language environment and measured their resultant vocabulary expansion. We found that infants can learn and exploit a natural language syntactic–semantic link in less than 30 min. The rapid speed of acquisition of a new syntactic bootstrap indicates that even emergent syntactic–semantic links can accelerate language learning. The results suggest that infants employ a cognitive network of efficient learning strategies to self-supervise language development. |
Aaron G. Beckner; Mary Katz; David N. Tompkins; Annika T. Voss; Deaven Winebrake; Vanessa LoBue; Lisa M. Oakes; Marianella Casasola A novel approach to assessing infant and child mental rotation Journal Article In: Journal of Intelligence, vol. 11, no. 8, pp. 1–21, 2023. @article{Beckner2023, Mental rotation is a critically important, early developing spatial skill that is related to other spatial cognitive abilities. Understanding the early development of this skill, however, requires a developmentally appropriate assessment that can be used with infants, toddlers, and young children. We present here a new eye-tracking task that uses a staircase procedure to assess mental rotation in 12-, 24-, and 36-month-old children (N = 41). To ensure that all children understood the task, the session began with training and practice, in which the children learned to fixate which of two houses a giraffe, facing either left or right, would approach. The adaptive two-up, one-down staircase procedure assessed the children's ability to fixate the correct house when the giraffe was rotated in 30° (up) or 15° (down) increments. The procedure was successful, with most children showing evidence of mental rotation. In addition, the children were less likely to succeed as the angle of rotation increased, and the older children succeeded at higher angles of rotation than the younger children, replicating previous findings with other procedures. The present study contributes a new paradigm that can assess the development of mental rotation in young children and holds promise for yielding insights into individual differences in mental rotation. |
Alessio Bellato; Iti Arora; Puja Kochhar; Danielle Ropar; Chris Hollis; Madeleine J. Groom Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism Journal Article In: Cortex, vol. 166, pp. 306–321, 2023. @article{Bellato2023, Introduction: Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) may be characterized by different profiles of visual attention orienting. However, there are also many inconsistent findings emerging from the literature, probably due to the fact that the potential effect of autonomic arousal (which has been proposed to be dysregulated in these conditions) on oculomotor performance has not been investigated before. Moreover, it is not known how visual attention orienting is affected by the co-occurrence of ADHD and autism in people with a double diagnosis. Methods: 99 children/adolescents with or without ADHD and/or autism (age 10.79 ± 2.05 years, 65% boys) completed an adapted version of the gap-overlap task (with baseline and overlap trials only). The social salience and modality of stimuli were manipulated between trials. Eye movements and pupil size were recorded. We compared saccadic reaction times (SRTs) between diagnostic groups and investigated if a trial-by-trial association existed between pre-saccadic pupil size and SRTs. Results: Faster orienting (shorter SRT) was found for baseline compared to overlap trials, faces compared to non-face stimuli and–more evidently in children without ADHD and/or autism–for multi-modal compared to uni-modal stimuli. We also found a linear negative association between pre-saccadic pupil size and SRTs, in autistic participants (without ADHD), and a quadratic association in children with ADHD (without autism), for which SRTs were slower when intra-individual pre-saccadic pupil size was smallest or largest. Conclusion: Our findings are in line with previous literature and indicate a possible effect of dysregulated autonomic arousal on oculomotor mechanisms in autism and ADHD, which should be further investigated in future research studies with larger samples, to reliably investigate possible differences between children with single and dual diagnoses. |
Nathaniel J. Blanco; Brandon M. Turner; Vladimir M. Sloutsky The benefits of immature cognitive control: How distributed attention guards against learning traps Journal Article In: Journal of Experimental Child Psychology, vol. 226, pp. 1–16, 2023. @article{Blanco2023, Cognitive control allows one to focus one's attention efficiently on relevant information while filtering out irrelevant information. This ability provides a means of rapid and effective learning, but using this control also brings risks. Importantly, useful information may be ignored and missed, and learners may fall into “learning traps” (e.g., learned inattention) wherein they fail to realize that what they ignore carries important information. Previous research has shown that adults may be more prone to such traps than young children, but the mechanisms underlying this difference are unclear. The current study used eye tracking to examine the role of attentional control during learning in succumbing to these learning traps. The participants, 4-year-old children and adults, completed a category learning task in which an unannounced switch occurred wherein the feature dimensions most relevant to correct categorization became irrelevant and formerly irrelevant dimensions became relevant. After the switch, adults were more likely than children to ignore the new highly relevant dimension and settle on a suboptimal categorization strategy. Furthermore, eye-tracking analyses reveal that greater attentional selectivity during learning (i.e., optimizing attention to focus only on the most relevant sources of information) predicted this tendency to miss important information later. Children's immature cognitive control, leading to broadly distributed attention, appears to protect children from this trap—although at the cost of less efficient and slower learning. These results demonstrate the double-edged sword of cognitive control and suggest that immature control may serve an adaptive function early in development. |
Christina M. Blomquist; Rochelle S. Newman; Jan Edwards The development of spoken word recognition in informative and uninformative sentence contexts Journal Article In: Journal of Experimental Child Psychology, vol. 227, pp. 1–10, 2023. @article{Blomquist2023, Although there is ample evidence documenting the development of spoken word recognition from infancy to adolescence, it is still unclear how development of word-level processing interacts with higher-level sentence processing, such as the use of lexical–semantic cues, to facilitate word recognition. We investigated how the ability to use an informative verb (e.g., draws) to predict an upcoming word (picture) and suppress competition from similar-sounding words (pickle) develops throughout the school-age years. Eye movements of children from two age groups (5–6 years and 9–10 years) were recorded while the children heard a sentence with an informative or neutral verb (The brother draws/gets the small picture) in which the final word matched one of a set of four pictures, one of which was a cohort competitor (pickle). Both groups demonstrated use of the informative verb to more quickly access the target word and suppress cohort competition. Although the age groups showed similar ability to use semantic context to facilitate processing, the older children demonstrated faster lexical access and more robust cohort suppression in both informative and uninformative contexts. This suggests that development of word-level processing facilitates access of top-down linguistic cues that support more efficient spoken language processing. Whereas developmental differences in the use of semantic context to facilitate lexical access were not explained by vocabulary knowledge, differences in the ability to suppress cohort competition were explained by vocabulary. This suggests a potential role for vocabulary knowledge in the resolution of lexical competition and perhaps the influence of lexical competition dynamics on vocabulary development. |
Christina Blomquist; Bob MCMurray The development of lexical inhibition in spoken word recognition Journal Article In: Developmental Psychology, vol. 59, no. 1, pp. 186–206, 2023. @article{Blomquist2023a, As a spoken word unfolds over time, similar sounding words (cap and cat) compete until one word “wins”. Lexical competition becomes more efficient from infancy through adolescence. We examined one potential mechanism underlying this development: lexical inhibition, by which activated candidates suppress competitors. In Experiment 1, younger (7–8 years) and older (12–13 years) children heard words (cap) in which the onset was manipulated to briefly boost competition from a cohort competitor (cat). This was compared to a condition with a nonword (cack) onset that would not inhibit the target. Words were presented in a visual world task during which eye movements were recorded. Both groups showed less looking to the target when perceiving the competitor-splice relative to the nonword-splice, showing engagement of lexical inhibition. Exploratory analyses of linguistic adaptation across the experiment revealed that older children demonstrated consistent lexical inhibition across the experiment and younger children did not, initially showing no effect in the first half of trials and then a robust effect in the latter half. In Experiment 2, adults also displayed consistent lexical inhibition in the same task. These findings suggest that younger children do not consistently engage lexical inhibition in typical listening but can quickly bring it online in response to certain linguistic experiences. Computational modeling showed that age-related differences are best explained by increased engagement of inhibition rather than growth in activation. These findings suggest that continued development of lexical inhibition in later childhood may underlie increases in efficiency of spoken word recognition. |
Alessandra Valentini; Rachel E. Pye; Carmel Houston-Price; Jessie Ricketts; Julie A. Kirkby Onlineprocessing shows advantages of bimodal listening-while-reading for vocabulary learning: An eye-tracking study Journal Article In: Reading Research Quarterly, vol. 59, no. 1, pp. 79–101, 2023. @article{Valentini2023, Children can learn words incidentally from stories. This kind of learning is enhanced when stories are presented both aurally and in written format, compared to just a written presentation. However, we do not know why this bimodal presentation is beneficial. This study explores two possible explanations: whether the bimodal advantage manifests online during story exposure, or later, at word retrieval. We collected eye-movement data from 34 8-to 9-year-old children exposed to two stories, one presented in written format (reading condition), and the second presented aurally and written at the same time (bimodal condition). Each story included six unfamiliar words (non-words) that were repeated three times, as well as definitions and clues to their meaning. Following exposure, the learning of the new words' meanings was assessed. Results showed that, during story presentation, children spent less time fixating the new words in the bimodal condition, compared to the reading condition, indicating that the bimodal advantage occurs online. Learning was greater in the bimodal condition than the reading condition, which may reflect either an online bimodal advantage during story presentation or an advantage at retrieval. The results also suggest that the bimodal condition was more conducive to learning than the reading condition when children looked at the new words for a shorter amount of time. This is in line with an online advantage of the bimodal condition, as it suggests that less effort is required to learn words in this condition. These results support educational strategies that routinely present new vocabulary in two modalities simultaneously. |
Janneke E. P. Leeuwen; Amy McDougall; Dimitris Mylonas; Aida Suárez-González; Sebastian J. Crutch; Jason D. Warren Pupil responses to colorfulness are selectively reduced in healthy older adults Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 1–16, 2023. @article{Leeuwen2023a, The alignment between visual pathway signaling and pupil dynamics offers a promising non-invasive method to further illuminate the mechanisms of human color perception. However, only limited research has been done in this area and the effects of healthy aging on pupil responses to the different color components have not been studied yet. Here we aim to address this by modelling the effects of color lightness and chroma (colorfulness) on pupil responses in young and older adults, in a closely controlled passive viewing experiment with 26 broad-spectrum digital color fields. We show that pupil responses to color lightness and chroma are independent from each other in both young and older adults. Pupil responses to color lightness levels are unaffected by healthy aging, when correcting for smaller baseline pupil sizes in older adults. Older adults exhibit weaker pupil responses to chroma increases, predominantly along the Green–Magenta axis, while relatively sparing the Blue–Yellow axis. Our findings complement behavioral studies in providing physiological evidence that colors fade with age, with implications for color-based applications and interventions both in healthy aging and later-life neurodegenerative disorders. |
Katie Von Holzen; Sandrien Ommen; Katherine S. White; Thierry Nazzi The impact of phonological biases on mispronunciation sensitivity and novel accent adaptation Journal Article In: Language Learning and Development, vol. 19, no. 3, pp. 303–322, 2023. @article{VonHolzen2023, Successful word recognition requires that listeners attend to differences that are phonemic in the language while also remaining flexible to the variation introduced by different voices and accents. Previous work has demonstrated that American-English-learning 19-month-olds are able to balance these demands: although one-off one-feature mispronunciations typically disrupt English-learning toddlers' lexical access, they no longer do after toddlers are exposed to a novel accent in which these changes occur systematically. The flexibility to deal with different types of variation may not be the same for toddlers learning different first languages, however, as language structure shapes early phonological biases. We examined French-learning 19-month-olds' sensitivity and adaptation to a novel accent that shifted either the standard pronunciation of /a/ from [a] to [ɛ] (Experiment 1) or the standard pronunciation of /p/ from [p] to [t] (Experiment 2). In Experiment 1, French-learning toddlers recognized words with /a/ produced as [ɛ], regardless of whether they were previously exposed to an accent that contained this vowel shift or not. In Experiment 2, toddlers did not recognize words with /p/ pronounced as [t] at test unless they were first familiarized with an accent that contained this consonant shift. These findings are consistent with evidence that French-learning toddlers privilege consonants over vowels in lexical processing. Together with previous work, these results demonstrate both differences and similarities in how French- and English-learning children treat variation, in line with their language-specific phonological biases. |
A. C. L. Vrijling; M. J. Boer; R. J. Renken; J. B. C. Marsman; A. Grillini; C. E. Petrillo; J. Heutink; N. M. Jansonius; F. W. Cornelissen Stimulus contrast, pursuit mode, and age strongly influence tracking performance on a continuous visual tracking task Journal Article In: Vision Research, vol. 205, pp. 1–11, 2023. @article{Vrijling2023, Human observers tend to naturally track moving stimuli. This tendency may be exploited towards an intuitive means of screening visual function as an impairment induced reduction in stimulus visibility will decrease tracking performance. Yet, to be able to detect subtle impairments, stimulus contrast is critical. If too high, the decrease in performance may remain undetected. Therefore, for this approach to become reliable and sensitive, we need a detailed understanding of how age, stimulus contrast, and the type of stimulus movement affect continuous tracking performance. To do so, we evaluated how well twenty younger and twenty older participants tracked a semi-randomly moving stimulus (Goldmann size III, 0.43 degrees of visual angle), presented at five contrast levels (5%-10%-20%-40%-80%). The stimulus could move smoothly only (smooth pursuit mode) or in alternation with displacements (saccadic pursuit mode). Additionally, we assessed static foveal and peripheral contrast thresholds. For all participants, tracking performance improved with increasing contrast in both pursuit modes. To reach threshold performance levels, older participants required about twice as much contrast (20% vs. 10% and 40% vs. 20% in smooth and saccadic modes respectively). Saccadic pursuit detection thresholds correlated significantly with static peripheral contrast thresholds (rho = 0.64). Smooth pursuit detection thresholds were uncorrelated with static foveal contrast thresholds (rho = 0.29). We conclude that continuous visual stimulus tracking is strongly affected by stimulus contrast, pursuit mode, and age. This provides essential insights that can be applied towards new and intuitive approaches of screening visual function. |
Nicholas Wagner; Emily Perkins; Yuheiry Rodriguez; Cora Ordway; Michaela Flum; Lucia Hernandez-Pena; Polina Perelstein; Kathy Sem; Yael Paz; Rista Plate; Ayomide Popoola; Sarah Lynch; Kristina Astone; Ethan Goldstein; Wanjikũ F. M. Njoroge; Adriane Raine; Donna Pincus; Koraly Pérez-Edgar; Rebecca Waller In: BMJ Open, vol. 13, no. 10, pp. 1–13, 2023. @article{Wagner2023b, Introduction: Children with callous-unemotional (CU) traits are at high lifetime risk of antisocial behaviour. Low affiliation (ie, social bonding difficulties) and fearlessness (ie, low threat sensitivity) are proposed risk factors for CU traits. Parenting practices (eg, harshness and low warmth) also predict risk for CU traits. However, few studies in early childhood have identified attentional or physiological markers of low affiliation and fearlessness. Moreover, no studies have tested whether parenting practices are underpinned by low affiliation or fearlessness shared by parents, which could further shape parent-child interactions and exacerbate risk for CU traits. Addressing these questions will inform knowledge of how CU traits develop and isolate novel parent and child targets for future specialised treatments for CU traits. Methods and analysis: The Promoting Empathy and Affiliation in Relationships (PEAR) study aims to establish risk factors for CU traits in children aged 3-6 years. The PEAR study will recruit 500 parent-child dyads from two metropolitan areas of the USA. Parents and children will complete questionnaires, computer tasks and observational assessments, alongside collection of eye-tracking and physiological data, when children are aged 3-4 (time 1) and 5-6 (time 2) years. The moderating roles of child sex, race and ethnicity, family and neighbourhood disadvantage, and parental psychopathology will also be assessed. Study aims will be addressed using structural equation modelling, which will allow for flexible characterisation of low affiliation, fearlessness and parenting practices as risk factors for CU traits across multiple domains. Ethics and dissemination: Ethical approval was granted by Boston University (#6158E) and the University of Pennsylvania (#850638). Results will be disseminated through conferences and open-access publications. All study and task materials will be made freely available on lab websites and through the Open Science Framework (OSF). |
Carla A. Wall; Frederick Shic; Sreeja Varanasi; Jane E. Roberts Distinct social attention profiles in preschoolers with autism contrasted to fragile X syndrome Journal Article In: Autism Research, vol. 16, no. 2, pp. 340–354, 2023. @article{Wall2023, Social attention is a critical skill for learning and development. Social attention difficulties are present in both non-syndromic autism spectrum disorder (nsASD) and fragile X syndrome (FXS), and our understanding of these difficulties is complicated by heterogeneity in both disorders, including co-occurring diagnoses like intellectual disability and social anxiety. Existing research largely utilizes a single index of social attention and rarely includes children with intellectual impairment or uses a cross-syndrome approach. This study investigated whether multi-trait social attention profiles including naturalistic initial eye contact, facial attention, and social scene attention differ in preschool children with nsASD and FXS matched on developmental ability (DQ) and contrasted to neurotypical (NT) controls. The relationship between DQ, ASD severity, and social anxiety and social attention profiles was also examined. Initial eye contact related to social scene attention, implicating that naturalistic social attention is consistent with responses during experimental conditions. Reduced eye contact and lower social scene attention characterized nsASD and FXS. Children with nsASD displayed less facial attention than FXS and NT children, who did not differ. Lower DQ and elevated ASD severity associated with decreased eye contact in nsASD and FXS, and lower DQ was associated with lower social scene attention in FXS. Sex, social anxiety, and age were not associated with social attention. These findings suggest social attention profiles of children with nsASD are highly similar to, yet distinct from, children with FXS. Children with nsASD may present with a global social attention deficit whereas FXS profiles may reflect context-dependent social avoidance. |
Yingjia Wan; Yipu Wei; Baorui Xu; Liqi Zhu; Michael K. Tanenhaus Musical coordination affects children's perspective-taking, but musical synchrony does not Journal Article In: Developmental Science, vol. 26, no. 5, pp. 1–13, 2023. @article{Wan2023a, Perspective-taking, which is important for communication and social activities, can be cultivated through joint actions, including musical activities in children. We examined how rhythmic activities requiring coordination affect perspective-taking in a referential communication task with 100 Chinese 4- to 6-year-old children. In Study 1, 5- to 6-year-old children played an instrument with a virtual partner in one of three coordination conditions: synchrony, asynchrony, and antiphase synchrony. Eye movements were then monitored with the partner giving instructions to identify a shape referent which included a pre-nominal scalar adjective (e.g., big cubic block). When the target contrast (a small cubic block) was in the shared ground and a competitor contrast was occluded for the partner, participants who used perspective differences could, in principle, identify the intended referent before the shape was named. We hypothesized that asynchronous and antiphase synchronous musical activities, which require self-other distinction, might have stronger effects on perspective-taking than synchronous activity. Children in the asynchrony and antiphase synchrony conditions, but not the synchrony condition, showed anticipatory looks at the target, demonstrating real-time use of the partner's perspective. Study 2 was conducted to determine if asynchrony and antiphase asynchrony resulted in perspective-taking that otherwise would not have been observed, or if synchronous coordination inhibited perspective-taking that would otherwise have occurred. We found no evidence for online perspective-taking in 4- to 6-year-old children without music manipulation. Therefore, playing instruments asynchronously or in alternation, but not synchronously, increases perspective-taking in children of this age, likely by training self-other distinction and control. A video abstract of this article can be viewed at https://youtu.be/TM9h_GpFlsA. Research Highlights: This study is the first to show that rhythmic coordination, a form of non-linguistic interaction, can affect children's performance in a subsequent linguistic task. Eye-movement data revealed that children's perspective-taking in language processing was facilitated by prior asynchronous and antiphase synchronous musical interactions, but not by synchronous coordination. The results challenge the common “similar is better” view, suggesting that maintaining self-other distinction may benefit social interactions that involve representing individual differences. |
Yingjia Wan; Yipu Wei; Baorui Xu; Liqi Zhu; Michael K. Tanenhaus Musical coordination affects children's perspective-taking, but musical synchrony does not Journal Article In: Developmental Science, pp. 1–13, 2023. @article{Wan2023, Perspective-taking, which is important for communication and social activities, can be cultivated through joint actions, including musical activities in children. We examined how rhythmic activities requiring coordination affect perspective-taking in a referential communication task with 100 Chinese 4- to 6-year-old children. In Study 1, 5- to 6-year-old children played an instrument with a virtual partner in one of three coordination conditions: synchrony, asynchrony, and antiphase synchrony. Eye movements were then monitored with the partner giving instructions to identify a shape referent which included a pre-nominal scalar adjective (e.g., big cubic block). When the target contrast (a small cubic block) was in the shared ground and a competitor contrast was occluded for the partner, participants who used perspective differences could, in principle, identify the intended referent before the shape was named. We hypothesized that asynchronous and antiphase synchronous musical activities, which require self- other distinction, might have stronger effects on perspective-taking than synchronous activity. Children in the asynchrony and antiphase synchrony conditions, but not the synchrony condition, showed anticipatory looks at the target, demonstrating real-time use of the partner's perspective. Study 2 was conducted to determine if asynchrony and antiphase asynchrony resulted in perspective-taking that otherwise would not have been observed, or if synchronous coordination inhibited perspective-taking that wouldotherwise have occurred. We found no evidence for online perspective-taking in 4-to 6-year-old children without music manipulation. Therefore, playing instruments asynchronously or in alternation, but not synchronously, increases perspective-taking in children of this age, likely by training self-other distinction and control. |
Zhiyun Wang; Qingfang Zhang Ageing of grammatical advance planning in spoken sentence production: An eye movement study Journal Article In: Psychological Research, no. 2001, pp. 1–18, 2023. @article{Wang2023m, This study used an image-description paradigm with concurrent eye movement recordings to investigate differences of grammatical advance planning between young and older speakers in spoken sentence production. Participants were asked to produce sentences with simple or complex initial phrase structures (IPS) in Experiment 1 while producing individual words in Experiment 2. Young and older speakers showed comparable speaking latencies in sentence production task, whereas older speakers showed longer latencies than young speakers in word production task. Eye movement data showed that compared with young speakers, older speakers had higher fixation percentage on object 1, lower percentage of gaze shift from object 1 to 2, and lower fixation percentage on object 2 in simple IPS sentences, while they showed similar fixation percentage on object 1, similar percentage of gaze shift from object 1 to 2, and lower fixation percentage on object 2 in complex IPS sentences, indicating a decline of grammatical encoding scope presenting on eye movement patterns. Meanwhile, speech analysis showed that older speakers presented longer utterance duration, slower speech rate, and longer and more frequently occurred pauses in articulation, indicating a decline of speech articulation in older speakers. Thus, our study suggests that older speakers experience an ageing effect in the sentences with complex initial phrases due to limited cognitive resources. |
Sobanawartiny Wijeakumar; Samuel H. Forbes; Vincent A. Magnotta; Sean Deoni; Kiara Jackson; Vinay P. Singh; Madhuri Tiwari; Aarti Kumar; John P. Spencer Stunting in infancy is associated with atypical activation of working memory and attention networks Journal Article In: Nature Human Behaviour, vol. 7, no. 12, pp. 2199–2211, 2023. @article{Wijeakumar2023, Stunting is associated with poor long-term cognitive, academic and economic outcomes, yet the mechanisms through which stunting impacts cognition in early development remain unknown. In a first-ever neuroimaging study conducted on infants from rural India, we demonstrate that stunting impacts a critical, early-developing cognitive system—visual working memory. Stunted infants showed poor visual working memory performance and were easily distractible. Poor performance was associated with reduced engagement of the left anterior intraparietal sulcus, a region involved in visual working memory maintenance and greater suppression in the right temporoparietal junction, a region involved in attentional shifting. When assessed one year later, stunted infants had lower problem-solving scores, while infants of normal height with greater left anterior intraparietal sulcus activation showed higher problem-solving scores. Finally, short-for-age infants with poor physical growth indices but good visual working memory performance showed more positive outcomes suggesting that intervention efforts should focus on improving working memory and reducing distractibility in infancy. |
Hao Wu; Yuding Zhang; Qiong Luo; Zhengzhou Zhu The magnitude representations of fractions of Chinese students: Evidence from behavioral experiment and eye-tracking Journal Article In: Current Psychology, pp. 1–16, 2023. @article{Wu2023b, Early knowledge of fractions can largely predict later mathematical performance, and a comprehensive and in-depth understanding of fractions is fundamental to learning more advanced mathematics. The study aimed to explore the influencing factors and age characteristics of magnitude representations of fractions by a fraction comparison task, using subjects' eye-movement measures as direct evidence and the results of linear regression analyses as indirect evidence. The results found that the number of digits of fractions' components and types of fraction pairs jointly influence the magnitude representations of fractions. For one-digit fraction pairs with and without common components, componential representation is favored; for two-digit fraction pairs with common components, componential representation is preferred, while for two-digit fraction pairs without common components, holistic representation is selected. The representation styles are consistent across university students, junior high school students and primary school students, and there are significant age differences in representation levels, with university students being more flexible in their use of representation strategies of fractions than the other two ages, and junior high school students showing the same level with the primary school students. These results suggest that not only Chinese university students, but also Chinese primary and junior high school students can select and adapt representation strategies of fractions according to the characteristics and complexity of fraction processing tasks. The eye-movement technique can largely compensate for the shortcomings of the regression analysis paradigm and better reveal the critical cognitive processes involved in the processing of fractions. |
Naiqi G. Xiao; Lauren L. Emberson Visual perception is highly flexible and context dependent in young infants: A case of top-down-modulated motion perception Journal Article In: Psychological Science, vol. 34, no. 8, pp. 875–886, 2023. @article{Xiao2023, Top-down modulation is an essential cognitive component in human perception. Despite mounting evidence of top-down perceptual modulation in adults, it is largely unknown whether infants can engage in this cognitive function. Here, we examined top-down modulation of motion perception in 6- to 8-month-old infants (recruited in North America) via their smooth-pursuit eye movements. In four experiments, we demonstrated that infants' perception of motion direction can be flexibly shaped by briefly learned predictive cues when no coherent motion is available. The current findings present a novel insight into infant perception and its development: Infant perceptual systems respond to predictive signals engendered from higher-level learning systems, leading to a flexible and context-dependent modulation of perception. This work also suggests that the infant brain is sophisticated, interconnected, and active when placed in a context in which it can learn and predict. |
Kunyu Xu; Yu-Min Ku; Chenlu Ma; Chien-Hui Lin; Wan-Chen Chang Development of comprehension monitoring skill in Chinese children: Evidence from eye movement and probe interviews Journal Article In: Metacognition and Learning, pp. 1–19, 2023. @article{Xu2023, As an important construct in the cognitive process, comprehension monitoring has received much scholarly attention. Researchers have recognized comprehension monitoring as an ability closely linked with children's reading comprehension ability and working memory capacity. Evidence is also abundant to prove that comprehension monitoring skill develops with age. It remains unclear, however, how these factors interact during reading, particularly in low-grade children. Many previous empirical studies have only employed online or offline measurements to examine children's monitoring performance, which might lead to unsolid conclusions. In this study, we utilized both online eye-tracking measures and offline probe interviews to quantify the developmental features (i.e., evaluation and regulation) of comprehension monitoring skills among Chinese beginning readers. The results indicated that the comprehension monitoring performance, as quantified by eye-tracking measures, was positively related to their reading comprehension ability and working memory capacity. Moreover, the first-graders' performances lacked online regulation skills during the error-detecting tasks, while second-graders had relatively developed online monitoring performance. Additionally, the eye-tracking measures were found as a predictor for children's performances in probe interviews, as the readers with high comprehension ability and working memory capacity successfully reported more errors embedded in the self-designed reading materials. Therefore, the findings support the claim that children's comprehension monitoring is a developing skill associated with reading comprehension and working memory capacity and further question the existence of comprehension monitoring skills in beginning readers, especially first-graders. |
Licheng Xue; Ying Xiao; Tianying Qing; Urs Maurer; Wei Wang; Huidong Xue; Xuchu Weng; Jing Zhao Attention to the fine-grained aspect of words in the environment emerges in preschool children with high reading ability Journal Article In: Visual Cognition, vol. 31, no. 1, pp. 85–96, 2023. @article{Xue2023, Attention to words is closely related to the process of learning to read. However, it remains unclear how attention to words in environmental print (such as words on product labels) is changed with the growth of preschool children's reading ability. We thus used eye tracking technique to compare attention to words in environmental print in children at low (32, 15 males, 5.12 years) and high (32, 17 males, 5.16 years) reading levels during a free viewing task. To characterize which aspects of visual word form children attend to, we constructed three types of stimuli embedded in the same context: words in environment print, symbol strings (similar shape to words but without strokes), and character strings (comparable with words in the number of strokes and the structures). We observed that children at both reading levels showed lower percentages of fixations and fixation time in words relative to symbol strings, suggesting they start to attend to the coarse aspect of visual word form. Interestingly, only children at higher reading level showed lower percentages of fixations and fixation time for words relative to character strings, suggesting that attention to the fine-grained aspect of visual word form emerged, and was closely to reading ability. |
Ming Yan; Jinger Pan Joint effects of individual reading skills and word properties on Chinese children's eye movements during sentence reading Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 1–10, 2023. @article{Yan2023a, Word recognition during the reading of continuous text has received much attention. While a large body of research has investigated how linguistic properties of words affect eye movements during reading, it remains to be established how individual differences in reading skills affect momentary cognitive processes during sentence reading among typically developing Chinese readers. The present study set out to test the joint influences of word properties and individual reading skills on eye movements during reading among Chinese children. We recorded eye movements of 30 grade 3 (G3) children and 27 grade 5 (G5) children when they read sentences silently for comprehension. Predictors of linear mixed models included word frequency, visual complexity, and launch site distance, in addition to the participants' offline psychometric performances in rapid naming, morphological awareness, word segmenting, and character recognition. The results showed that word properties affected word recognition during sentence reading in both G3 and G5 children. Moreover, word segmenting predicted the G3 children's fixation durations and the G5 children's fixation location, whereas rapid naming predicted the G5 children's fixation duration. Implications are discussed based on the current findings, in light of how different literacy skills contribute to reading development. |
Tania S. Zamuner; Theresa Rabideau; Margarethe McDonald; H. Henny Yeung Developmental change in children's speech processing of auditory and visual cues: An eyetracking study Journal Article In: Journal of Child Language, vol. 50, pp. 27–51, 2023. @article{Zamuner2023, This study investigates how children aged two to eight years (N = 129) and adults (N = 29) use auditory and visual speech for word recognition. The goal was to bridge the gap between apparent successes of visual speech processing in young children in visual-looking tasks, with apparent difficulties of speech processing in older children from explicit behavioural measures. Participants were presented with familiar words in audio-visual (AV), audio-only (A-only) or visual-only (V-only) speech modalities, then presented with target and distractor images, and looking to targets was measured. Adults showed high accuracy, with slightly less target-image looking in the V-only modality. Developmentally, looking was above chance for both AV and A-only modalities, but not in the V-only modality until 6 years of age (earlier on /k/-initial words). Flexible use of visual cues for lexical access develops throughout childhood. |
Andrea M. Zawoyski; Scott P. Ardoin; Katherine S. Binder The impact of test-taking strategies on eye movements of elementary students during reading comprehension assessment Journal Article In: School Psychology, vol. 38, no. 1, pp. 59–66, 2023. @article{Zawoyski2023, Teachers often encourage students to use test-taking strategies during reading comprehension assessments, but these strategies are not always evidence-based. One common strategy involves teaching students to read the questions before reading an associated passage. Research findings comparing the passage-first (PF) and questions-first (QF) strategies are mixed. The present study employed eye-tracking technology to record 84 third and fourth-grade participants' eye movements (EMs) as they read a passage and responded to multiple-choice (MC) questions using PF and QF strategies in a within-subject design. Although there were no significant differences between groups in accuracy on MC questions, EM measures revealed that the PF condition was superior to the QF condition for elementary readers in terms of efficiency in reading and responding to questions. These findings suggest that the PF strategy supports a more comprehensive understanding of the text. Ultimately, within the PF condition, students required less time to obtain the same accuracy outcomes they attained when reading in the QF condition. School psychologists can improve reading comprehension instruction by encouraging the importance of teaching children to gain meaning from the text rather than search the passage for answers to MC questions |
Martin Zettersten; Daniel Yurovsky; Tian Linger Xu; Sarp Uner; Angeline Sin Mei Tsui; Rose M. Schneider; Annissa N. Saleh; Stephan C. Meylan; Virginia A. Marchman; Jessica Mankewitz; Kyle MacDonald; Bria Long; Molly Lewis; George Kachergis; Kunal Handa; Benjamin DeMayo; Alexandra Carstensen; Mika Braginsky; Veronica Boyce; Naiti S. Bhatt; Claire Augusta Bergey; Michael C. Frank Peekbank: An open, large-scale repository for developmental eye-tracking data of children's word recognition Journal Article In: Behavior Research Methods, vol. 55, no. 5, pp. 2485–2500, 2023. @article{Zettersten2023, The ability to rapidly recognize words and link them to referents is central to children's early language development. This ability, often called word recognition in the developmental literature, is typically studied in the looking-while-listening paradigm, which measures infants' fixation on a target object (vs. a distractor) after hearing a target label. We present a large-scale, open database of infant and toddler eye-tracking data from looking-while-listening tasks. The goal of this effort is to address theoretical and methodological challenges in measuring vocabulary development. We first present how we created the database, its features and structure, and associated tools for processing and accessing infant eye-tracking datasets. Using these tools, we then work through two illustrative examples to show how researchers can use Peekbank to interrogate theoretical and methodological questions about children's developing word recognition ability. |
Wei Zhou; Yi Fan; Yulin Chang; Wenjuan Liu; Jiuju Wang; Yufeng Wang Pathogenesis of comorbid adhd and chinese developmental dyslexia: Evidence from eye-movement tracking and rapid automatized naming Journal Article In: Journal of Attention Disorders, vol. 27, no. 3, pp. 294–306, 2023. @article{Zhou2023f, Background: ADHD and Chinese developmental dyslexia (DD) have a very high comorbidity rate; however, which cognitive deficits characterize the comorbidity and when they occur during cognitive processing are still under debate. Methods: Rapid automatic naming (RAN) tasks with eye-movement tracking were conducted with 75 children who were typically developing, had comorbid ADHD and DD, had only ADHD, and had only DD. Results: The clinical groups had longer first fixation durations than the control for RAN digits. Temporal eye-movement measures, such as gaze duration and total reading time, were found to vary between the comorbidity and ADHD groups. Spatial eye-movement measures, such as regression probability and incoming saccade amplitude, differed between the comorbidity and DD groups. Conclusions: These results indicate that investigation with eye-movement measures combined with RAN tasks can strengthen the understanding of the pathogenesis of comorbid ADHD and DD. |
Simeng Gu; Yao Jiang; Mei Liu; Yumeng Li; Yuan Liang; Rou Feng; Minghong Xu; Fushun Wang; Jason H. Huang Eye movements and ERP biomarkers for face processing problems in avoidant attachment-style individuals Journal Article In: Frontiers in Behavioral Neuroscience, vol. 17, pp. 1–11, 2023. @article{Gu2023, Background: Avoidant attachment poses a serious risk to intimate relationships and offspring. However, there are few studies on the face-processing characteristics and impairments of avoidant individuals based on basic emotion theory. Therefore, this study investigated the issues of emotional processing and deactivation strategies in individuals with avoidant attachment. Methods: Avoidant and secure individuals were recruited to participate in an eye-tracking experiment and a two-choice oddball task in which they had to distinguish facial expressions of basic emotions (sadness, anger, fear, disgust, and neutral). Eye fixation durations to various parts of the face, including the eyes, nose, and mouth, were measured, and three event-related potentials (ERP) components (P100, N170, and P300) were monitored. Results: Avoidant individuals could not process facial expressions as easily as secure individuals. Avoidant individuals focused less on the eyes of angry faces when compared to secure individuals. They also exhibited a more positive P100 component and a less negative N170 component when processing faces and a larger amplitude of the P300 component than secure individuals when processing emotional expressions. Conclusion: Avoidant individuals use deactivating strategies and exhibit specific characteristics at different stages, which are of great significance in social interaction. |
Leslie Guadron; Samuel A. Titchener; Carla J. Abbott; Lauren N. Ayton; John Opstal; Matthew A. Petoe; Jeroen Goossens The saccade main sequence in patients with retinitis pigmentosa and advanced age-related macular degeneration Journal Article In: Investigative Ophthalmology & Visual Science, vol. 64, no. 3, pp. 1–18, 2023. @article{Guadron2023, PURPOSE. Most eye-movement studies in patients with visual field defects have examined the strategies that patients use while exploring a visual scene, but they have not investigated saccade kinematics. In healthy vision, saccade trajectories follow the remarkably stereotyped “main sequence”: saccade duration increases linearly with saccade amplitude; peak velocity also increases linearly for small amplitudes, but approaches a saturation limit for large amplitudes. Recent theories propose that these relationships reflect the brain's attempt to optimize vision when planning eye movements. Therefore, in patients with bilateral retinal damage, saccadic behavior might differ to optimize vision under the constraints imposed by the visual field defects. METHODS. We compared saccadic behavior of patients with central vision loss, due to age-related macular degeneration (AMD), and patients with peripheral vision loss, due to retinitis pigmentosa (RP), to that of controls with normal vision (NV) using a horizontal saccade task. RESULTS. Both patient groups demonstrated deficits in saccade reaction times and target localization behavior, as well as altered saccade kinematics. Saccades were generally slower and the shape of the velocity profiles were often atypical, especially in the patients with RP. In the patients with AMD, the changes were far less dramatic. For both groups, saccade kinematics were affected most when the target was in the subjects' blind field. CONCLUSIONS. We conclude that defects of the central and peripheral retina have distinct effects on the saccade main sequence, and that visual inputs play an important role in planning the kinematics of a saccade. |
J. Hartman; J. Saffran; R. Litovsky Word learning in deaf adults who use cochlear implants: The role of talker variability and attention to the mouth Journal Article In: Ear & Hearing, pp. 1–14, 2023. @article{Hartman2023, OBJECTIVES: Although cochlear implants (CIs) facilitate spoken language acquisition, many CI listeners experience difficulty learning new words. Studies have shown 29that highly variable stimulus input and audiovisual cues improve speech perception in CI listeners. However, less is known whether these two factors improve perception in a word learning context. Furthermore, few studies have examined how CI listeners direct their gaze to efficiently capture visual information available on a talker's face. The purpose of this study was two-fold: (1) to examine whether talker variability could improve word learning in CI listeners and (2) to examine how CI listeners direct their gaze while viewing a talker speak. DESIGN: Eighteen adults with CIs and 10 adults with normal hearing (NH) learned eight novel word-object pairs spoken by a single talker or six different talkers (multiple talkers). The word learning task comprised of nonsense words following the phonotactic rules of English. Learning was probed using a novel talker in a two-alternative forced-choice eye gaze task. Learners' eye movements to the mouth and the target object (accuracy) were tracked over time. RESULTS: Both groups performed near ceiling during the test phase, regardless of whether they learned from the same talker or different talkers. However, compared to listeners with NH, CI listeners directed their gaze significantly more to the talker's mouth while learning the words. CONCLUSIONS: Unlike NH listeners who can successfully learn words without focusing on the talker's mouth, CI listeners tended to direct their gaze to the talker's mouth, which may facilitate learning. This finding is consistent with the hypothesis that CI listeners use a visual processing strategy that efficiently captures redundant audiovisual speech cues available at the mouth. Due to ceiling effects, however, it is unclear whether talker variability facilitated word learning for adult CI listeners, an issue that should be addressed in future work using more difficult listening conditions. |
Kara Hawthorne; Susan J. Loveall In: Journal of Speech, Language, and Hearing Research, vol. 66, no. 9, pp. 3606–3621, 2023. @article{Hawthorne2023, Purpose: Pronouns are referentially ambiguous: For example, “she” could refer to any female. Nonetheless, errors in pronoun interpretation rarely occur for adults with typical development (TD) due to several strategies implicitly shared between the talker and listener. The purpose of this study was to test the impacts of syntactic, semantic, and prosodic prominence on pronoun interpre-tation for adults with intellectual and developmental disabilities (IDD) and TD. Method: Adults with IDD (n =28) andTD (n = 27) listened to ministories involving a pronoun with two potential antecedents that varied in syntactic, semantic, and prag-matic prominence. Subject/first-mentioned antecedents are more syntactically prominent than object antecedents. Semantic prominence was manipulated via verb transitivity: Subjects are more semantically prominent when the verb is highly transitive (e.g., “hit” vs. “see,” a low-transitivity verb for which the subject is merely experiencing the action). Pragmatic prominence was manipulated by placing pro-sodic focus on one of the two potential antecedents. Eye gaze to images represent-ing the potential antecedents was tracked as a measure of online processing. Responses to a follow-up pronoun interpretation question were also recorded. Results: Adults with TD used syntactic, semantic, and—in early processing— pragmatic prominence when interpreting ambiguous pronouns. Adults with IDD were sensitive to syntactic prominence but to a significantly lesser extent than their peers with TD. Conclusions: Pronouns are an integral part of everyday conversation, and when the conversational partners do not share common strategies to link ambiguous pronouns with their antecedents, misunderstandings will occur. Results show that adults with IDD only weakly share pronoun interpretation strategies with adults with TD, suggesting that pronouns may be an important focus for inter-vention for this population. |
Anne Sophie Hildebrand; Fabian Breuer; Elisabeth Johanna Leehr; Johannes B. Finke; Leandra Bucher; Tim Klucken; Udo Dannlowski; Kati Roesmann Inhibitory control and its modification in spider phobia – Study protocol for an antisaccade training trial Journal Article In: PLoS ONE, vol. 18, pp. 1–14, 2023. @article{Hildebrand2023, Objectives Inhibitory control deficits are considered a key pathogenic factor in anxiety disorders. To assess inhibitory control, the antisaccade task is a well-established measure that assesses antisaccade performance via latencies and error rates. The present study follows three aims: (1) to investigate inhibitory control via antisaccade latencies and errors in an antisaccade task, and their associations with multiple measures of fear in patients with spider phobia (SP) versus healthy controls (HC), (2) to investigate the modifiability of antisaccade performance via a fear-specific antisaccade training in patients with SP and HC, and (3) to explore associations between putative training-induced changes in antisaccade performance in SPs and changes in diverse measures of fear. Methods Towards aim 1, we assess antisaccade latencies (primary outcome) and error rates (secondary outcome) in an emotional antisaccade task. Further, the baseline assessment includes assessments of psychophysiological, behavioral, and psychometric indices of fear in patients with SP and HCs. To address aim 2, we compare effects of a fear-specific antisaccade training with effects of a prosaccade training as a control condition. The primary and secondary outcomes are reassessed at a post-1-assessment in both SPs and HCs. Aim 3 employs a cross-over design and is piloted in patients with SP, only. Towards this aim, primary and secondary outcomes, as well as psychophysiological, behavioral, and psychometric measures of fear are reassessed at a post-2-assessment after the second training block. Conclusion This study aims to better understand inhibitory control processes and their modifiability in spider phobia. If successful, antisaccade training may assist in the treatment of specific phobia by directly targeting the putative underlying inhibitory control deficits. This study has been preregistered with ISRCTN (ID: ISRCTN12918583) on 28th February 2022. |
Jaakko Hotta; Jukka Saari; Hanna Harno; Eija Kalso; Nina Forss; Riitta Hari Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1 Journal Article In: Human Brain Mapping, vol. 44, no. 17, pp. 6258–6274, 2023. @article{Hotta2023, In complex regional pain syndrome (CRPS), the representation area of the affected limb in the primary sensorimotor cortex (SM1) reacts abnormally during sensory stimulation and motor actions. We recorded 3T functional magnetic resonance imaging resting-state data from 17 upper-limb CRPS type 1 patients and 19 healthy control subjects to identify alterations of patients' SM1 function during spontaneous pain and to find out how the spatial distribution of these alterations were related to peripheral symptoms. Seed-based correlations and independent component analyses indicated that patients' upper-limb SM1 representation areas display (i) reduced interhemispheric connectivity, associated with the combined effect of intensity and spatial extent of limb pain, (ii) increased connectivity with the right anterior insula that positively correlated with the duration of CRPS, (iii) increased connectivity with periaqueductal gray matter, and (iv) disengagement from the other parts of the SM1 network. These findings, now reported for the first time in CRPS, parallel the alterations found in patients suffering from other chronic pain conditions or from limb denervation; they also agree with findings in healthy persons who are exposed to experimental pain or have used their limbs asymmetrically. Our results suggest that CRPS is associated with a sustained and somatotopically specific alteration of SM1 function, that has correspondence to the spatial distribution of the peripheral manifestations and to the duration of the syndrome. |
Monja Hoven; Alejandro Hirmas; Jan Engelmann; Ruth Holst The role of attention in decision-making under risk in gambling disorder: An eye-tracking study Journal Article In: Addictive Behaviors, vol. 138, pp. 1–10, 2023. @article{Hoven2023, Gambling disorder (GD) is a behavioural addiction characterized by impairments in decision-making, favouring risk- and reward-prone choices. One explanatory factor for this behaviour is a deviation in attentional processes, as increasing evidence indicates that GD patients show an attentional bias toward gambling stimuli. However, previous attentional studies have not directly investigated attention during risky decision-making. 26 patients with GD and 29 healthy matched controls (HC) completed a mixed gambles task combined with eye-tracking to investigate attentional biases for potential gains versus losses during decision-making under risk. Results indicate that compared to HC, GD patients gambled more and were less loss averse. GD patients did not show a direct attentional bias towards gains (or relative to losses). Using a recent (neuro)economics model that considers average attention and trial-wise deviations in average attention, we conducted fine-grained exploratory analyses of the attentional data. Results indicate that the average attention for gains in GD patients moderated the effect of gain value on gambling choices, whereas this was not the case for HC. GD patients with high average attention for gains started gambling at less high gain values. A similar trend-level effect was found for losses, where GD patients with high average attention for losses stopped gambling at lower loss values. This study gives more insight into how attentional processes in GD play a role in gambling behaviour, which could have implications for the development of future treatments focusing on attentional training or for the development of interventions that increase the salience of losses. |
Yiru Huang; Zitian Liu; Zidong Chen; Zongyi Zhan; Le Gao; Jingyi Hu; Yanyan Wu; Fang-Fang Yan; Daming Deng; Chang-Bing Huang; Minbin Yu Visual crowding reveals field- and axis-specific cortical miswiring after long-term axial misalignment in strabismic patients without amblyopia Journal Article In: Investigative Ophthalmology & Visual Science, vol. 64, no. 1, pp. 1–11, 2023. @article{Huang2023, PURPOSE. Inspired by physiological and neuroimaging findings that revealed squint- induced modification of cortical volume and visual receptive field in early visual areas, we hypothesized that strabismic eyes without amblyopia manifest an increase in critical spacing of visual crowding, an essential bottleneck on object recognition and reliable psychophysical index of cortical organization. METHODS. We used real-time eye tracking to ensure gaze-contingent display and examined visual crowding in patients with horizontal concomitant strabismus (both esotropia and exotropia) but without amblyopia and age-matched normal controls. RESULTS. Nineteen patients with exotropia (12 men, mean ± SD = 22.89 ± 7.82 years), matched normal controls (7 men, mean ± SD = 23.07 ± 1.07 years) participated in this 21 patients with esotropia (10 men, mean ± SD = 23.48 ± 6.95 years), and 14 age- study. We found that patients with strabismus without amblyopia showed significantly larger critical spacing with nasotemporal asymmetry in only the radial axis that related to the strabismus pattern, with exotropia exhibiting stronger temporal hemifield crowding and esotropia exhibiting stronger nasal hemifield crowding, in both the deviated and fixating eyes. Moreover, the magnitude of crowding change was related to the duration and degree of strabismic deviation. CONCLUSIONS. Using visual crowding as a psychophysical index of cortical organization, our study demonstrated significantly greater peripheral visual crowding with nasotemporal asymmetry in only the radial axis in patients with strabismus without amblyopia, indicating the existence of hemifield- and axis-specific miswiring of cortical processing in object recognition induced by long-term adaptation to ocular misalignment. |
Yiru Huang; Zitian Liu; Mingqin Wang; Le Gao; Yanyan Wu; Jingyi Hu; Zhenyu Zhang; Fang-Fang Yan; Daming Deng; Chang-Bing Huang; Minbin Yu Cortical reorganization after optical alignment in strabismic patients outside of critical period Journal Article In: Investigative Ophthalmology & Visual Science, vol. 64, no. 11, pp. 1–13, 2023. @article{Huang2023f, PURPOSE. To measure visual crowding, an essential bottleneck on object recognition and reliable psychophysical index of cortex organization, in older children and adults with horizontal concomitant strabismus before and after strabismus surgery. METHODS. Using real-time eye tracking to ensure gaze-contingent display, we examined the peripheral visual crowding effects in older children and adults with horizontal concomitant strabismus but without amblyopia before and after strabismus surgery. Patients were asked to discriminate the orientation of the central tumbling E target letter with flankers arranged along the radial or tangential axis in the nasal or temporal hemifield at different eccentricities (5° or 10°). The critical spacing value, which is the minimum space between the target and the flankers required for correct discrimination, was obtained for comparisons before and after strabismus surgery. RESULTS. Twelve individuals with exotropia (6 males, 21.75 ± 7.29 years, mean ± SD) and 15 individuals with esotropia (6 males, 24.13 ± 5.96 years) participated in this study. We found that strabismic individuals showed significantly larger critical spacing with nasotemporal asymmetry along the radial axis that related to the strabismus pattern, with exotropes exhibiting stronger temporal field crowding and esotropes exhibiting stronger nasal field crowding before surgical alignment. After surgery, the critical spacing was reduced and rebalanced between the nasal and temporal hemifields. Furthermore, the postoperative recovery of stereopsis was associated with the extent of nasotemporal balance of critical spacing. CONCLUSIONS. We find that optical realignment (i.e., strabismus surgery) can normalize the enlarged visual crowding effects, a reliable psychophysical index of cortical organization, in the peripheral visual field of older children and adults with strabismus and rebalance the nasotemporal asymmetry of crowding, promoting the recovery of postoperative stereopsis. Our results indicated a potential of experience-dependent cortical organization after axial alignment even for individuals who are out of the critical period of visual development, illuminating the capacity and limitations of optics on sensory plasticity and emphasizing the importance of ocular correction for clinical practice. |
Falk Huettig; Cesko C. Voeten; Esther Pascual; Junying Liang; Florian Hintz Do autistic children differ in language-mediated prediction? Journal Article In: Cognition, vol. 239, pp. 1–7, 2023. @article{Huettig2023, Prediction appears to be an important characteristic of the human mind. It has also been suggested that prediction is a core difference of autistic1 children. Past research exploring language-mediated anticipatory eye movements in autistic children, however, has been somewhat contradictory, with some studies finding normal anticipatory processing in autistic children with low levels of autistic traits but others observing weaker prediction effects in autistic children with less receptive language skills. Here we investigated language-mediated anticipatory eye movements in young children who differed in the severity of their level of autistic traits and were in professional institutional care in Hangzhou, China. We chose the same spoken sentences (translated into Mandarin Chinese) and visual stimuli as a previous study which observed robust prediction effects in young children (Mani & Huettig, 2012) and included a control group of typically-developing children. Typically developing but not autistic children showed robust prediction effects. Most interestingly, autistic children with lower communication, motor, and (adaptive) behavior scores exhibited both less predictive and non-predictive visual attention behavior. Our results raise the possibility that differences in language-mediated anticipatory eye movements in autistic children with higher levels of autistic traits may be differences in visual attention in disguise, a hypothesis that needs further investigation. |
Aoife M. L. Hunter; Roger S. Anderson; Tony Redmond; David F. Garway-Heath; Pádraig J. Mulholland Investigating the spatiotemporal summation of perimetric stimuli in dry age-related macular degeneration Journal Article In: Translational Vision Science & Technology, vol. 12, no. 11, pp. 1–17, 2023. @article{Hunter2023, Purpose: To measure achromatic spatial, temporal, and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls under conditions of photopic gaze-contingent perimetry. Methods: Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco's area (RA) at 2.5° and 5° eccentricities along the 0°, 90°, 180°, and 270° meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7–190.4 ms) with a Goldmann III stimulus (GIII, 0.43°) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal summation (using the GIII stimulus) and spatiotempo-ral summation (using the RA stimuli) was estimated using iterative two-phase regression analysis. Results: Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09–0.41] deg2; 5°: 0.32 [0.15–0.65 deg2 ]) compared to healthy controls (2.5°: 0.08 [0.05–0.13] deg2; 5°: 0.15 [0.08–0.22] deg2 ) at all test locations (all P < 0.05). No significant difference in median critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9–30.4] ms) and RA-scaled stimuli (22.9 [13.9–40.3] ms) compared to healthy controls (GIII: 17.0 [11.3–24.0] ms; RA-scaled: 22.4 [14.3–33.1] ms) at all test locations (all P > 0.05). Conclusions: Spatial summation is altered in dry AMD, without commensurate changes in temporal summation. Translational Relevance: The sensitivity of perimetry to AMD may be improved by utilizing stimuli that probe alterations in spatial summation in the disease. |
Satomi Inomata-Terada; Hideki Fukuda; Shin-ichi Tokushige; Shun-ichi Matsuda; Masashi Hamada; Yoshikazu Ugawa; Shoji Tsuji; Yasuo Terao Abnormal saccade profiles in hereditary spinocerebellar degeneration reveal cerebellar contribution to visually guided saccades Journal Article In: Clinical Neurophysiology, vol. 154, pp. 70–84, 2023. @article{InomataTerada2023, Objective: To study how the pathophysiology underlying hereditary spinocerebellar degeneration (spinocerebellar ataxia; SCA) with pure cerebellar manifestation evolves with disease progression using saccade recordings. Methods: We recorded visually- (VGS) and memory-guided saccade (MGS) task performance in a homogeneous population of 20 genetically proven SCA patients (12 SCA6 and eight SCA31 patients) and 19 normal controls. Results: For VGS but not MGS, saccade latency and amplitude were increased and more variable than those in normal subjects, which correlated with cerebellar symptom severity assessed using the International Cooperative Ataxia Rating Scale (ICARS). Parameters with significant correlations with cerebellar symptoms showed an aggravation after disease stage progression (ICARS > 50). The saccade velocity profile exhibited shortened acceleration and prolonged deceleration, which also correlated with disease progression. The main sequence relationship between saccade amplitude and peak velocity as well as saccade inhibitory control were preserved. Conclusions: The cerebellum may be involved in initiating VGS, which was aggravated acutely during disease stage progression. Dysfunction associated with disease progression occurs mainly in the cerebellum and brainstem interaction but may also eventually involve cortical saccade processing. Significance: Saccade recording can reveal cerebellar pathophysiology underlying SCA with disease progression. |
Thomas R. Barber; Kinan Muhammed; Daniel Drew; Kevin M. Bradley; Daniel R. McGowan; Johannes C. Klein; Sanjay G. Manohar; Michele T. M. Hu; Masud Husain Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder Journal Article In: Brain, vol. 146, no. 6, pp. 2502–2511, 2023. @article{Barber2023, Idiopathic rapid eye movement sleep behaviour disorder (iRBD) has now been established as an important marker of the prodromal stage of Parkinson's disease and related synucleinopathies. However, although dopamine transporter single photon emission computed tomography (SPECT) has been used to demonstrate the presence of nigro-striatal deficit in iRBD, quantifiable correlates of this are currently lacking. Sensitivity to rewarding stimuli is reduced in some people with Parkinson's disease, potentially contributing to aspects of the neuropsychiatric phenotype in these individuals. Furthermore, a role for dopaminergic degeneration is suggested by the fact that reward insensitivity can be improved by dopaminergic medications. Patients with iRBD present a unique opportunity to study the relationship between reward sensitivity and early dopaminergic deficit in the unmedicated state. Here, we investigate whether a non-invasive, objective measure of reward sensitivity might be a marker of dopaminergic status in prodromal Parkinson's disease by comparing with SPECT/CT measurement of dopaminergic loss in the basal ganglia. Striatal dopaminergic deficits in iRBD are associated with progression to Parkinsonian disorders. Therefore, identification of a clinically measurable correlate of this degenerative process might provide a basis for the development of novel risk stratification tools. Using a recently developed incentivized eye-tracking task, we quantified reward sensitivity in a cohort of 41 patients with iRBD and compared this with data from 40 patients with Parkinson's disease and 41 healthy controls. Patients with iRBD also underwent neuroimaging with dopamine transporter SPECT/CT. Overall, reward sensitivity, indexed by pupillary response to monetary incentives, was reduced in iRBD cases compared with controls and was not significantly different to that in patients with Parkinson's disease. However, in iRBD patients with normal dopamine transporter SPECT/CT imaging, reward sensitivity was not significantly different from healthy controls. Across all iRBD cases, a positive association was observed between reward sensitivity and dopaminergic SPECT/CT signal in the putamen. These findings demonstrate a direct relationship between dopaminergic deficit and reward sensitivity in patients with iRBD and suggest that measurement of pupillary responses could be of value in models of risk stratification and disease progression in these individuals. |
Dana Basel; Amit Lazarov A sight for sore eyes? Attention allocation to obsession-provoking stimuli and stimuli reflecting compulsion completion Journal Article In: Motivation and Emotion, pp. 1–15, 2023. @article{Basel2023, Research on attention allocation in OCD has exclusively used obsession-provoking threat stimuli, showing sustained attention over neutral ones. Recently, however, a study contrasting neutral stimuli with stimuli depicting the completion of compulsive acts (end-states stimuli), which is associated with a reduced anxiety (negative reinforcement), showed similar results. Yet, as relative to neutral stimuli end-state stimuli were also OCD-related, these results may still reflect obsession-related distress rather than relief brought on by stimuli signaling compulsion completion. Also, end-states stimuli were not systematically validated. In Study 1, participants rated the subjective discomfort experienced when viewing traditional obsession-provoking threat pictures and novel end-states pictures. We first compared participants with high (HOC) and low (LOC) levels of obsessive-compulsive symptoms, and then clinically diagnosed OCD participants and matched healthy controls. In study 2, we compared gaze patterns of HOC and LOC participants while freely viewing 2-by-2 matrices directly contrasting two threat and two end-state stimuli. Study 1 showed a larger difference in experienced discomfort when viewing the end-state stimuli, compared to threat stimuli, for both OC groups compared with their respected control groups. Study 2 showed that while LOC participants demonstrated no difference in dwell time on threat vs. end-state pictures, the HOC group allocated more attention toward the latter. Both groups were more prone to fixate first the threat pictures. Task reliability was high. Attention allocation in OCD may also be affected by cues signaling the completion of compulsive acts. |
Dana Basel; Moriah Magen; Amit Lazarov Increased attention allocation to stimuli reflecting end-states of compulsive behaviors among obsessive compulsive individuals Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 14–18, 2023. @article{Basel2023a, Attentional research in OCD has focused solely on threat stimuli, assumed to provoke related obsessions and ensuing compulsions. OCD-related stimuli depicting the completion of compulsive acts (“end-states”) have yet to be examined. Past research also neglected to explore the reliability of tasks used. Here, attention allocation to both stimuli types was examined. Participants with high (HOC) and low (LOC) levels of obsessive–compulsive symptoms freely viewed three blocks of 30 two-by-two picture matrices, each including two OCD-related (cleaning$backslash$checking$backslash$ordering) and two neutral pictures, presented for eight seconds, while their gaze was recorded. Participants completed two task versions – one with traditional threat stimuli and one with novel stimuli signaling compulsions end-states. Only the end-state version yielded significant results, showing that HOC participants, compared to LOC participants, spent significantly more time fixating on OCD-related stimuli. Results remained significant after controlling for anxiety, stress, and depression. Task reliability was high. OCD-related stimuli signaling end-states of compulsive behavior should be incorporated in attentional research in OCD. |
Mehdi Bejani; Elisa Luque-Buzo; Arsen Burlaka-Petrash; Jorge A. Gomez-Garcia; Julian D. Arias-Londono; F. Grandas-Perez; Jesus Grajal; Juan Ignacio Godino-Llorente Baseline wander removal applied to smooth pursuit eye movements from parkinsonian patients Journal Article In: IEEE Access, vol. 11, pp. 32119–32133, 2023. @article{Bejani2023, Prior studies aiming to parametrize the sequences obtained from the Smooth Pursuit Eye Movements (SPEM) of patients with Parkinson's disease are based on the manual extraction of cues of interest. This is because methods to automatically extract the relevant information are complex to implement and are constrained, in part, by the appearance of a baseline wander (BW). Thus, new methods are required for preprocessing the SPEM sequences to make the potential parameterisation procedures much more robust, removing the aforementioned BW. In this respect, the present study compares different BW removal methods applied to SPEM sequences based on several objective evaluation metrics. At the same time, it proposes a set of guidelines to estimate the ground truth that is required for comparison purposes. Data were collected using a high-speed video-based eye-tracking device. 52 patients and 60 controls and 12 young participants were enrolled in the study. The ground truth required to compare the different BW removal techniques was manually delineated according to a predefined protocol. Seven methods were developed to remove the BW, and four objective metrics were used to evaluate the results. According to the results, a method based on the Empirical Wavelet Transform provided the best performance removing the BW. Furthermore, the objective and subjective results show that potential asymmetries between left and right eye movements are solved by removing the BW. Regardless of the techniques used, BW removal is revealed to be a crucial step for any autonomous SPEM processing tool. |
Judith Bek; Emma Gowen; Stefan Vogt; Trevor J. Crawford; Ellen Poliakoff Observation and imitation of object-directed hand movements in Parkinson's disease Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 1–9, 2023. @article{Bek2023, Action observation and imitation may facilitate movement in Parkinson's disease (PD). People with PD have been found to imitate intransitive actions similarly to neurologically healthy older adults, but their imitation of object-directed hand movements has not previously been investigated using kinematic measures. The present study examined observation and imitation of object-directed hand movements in 18 participants with PD and 21 neurologically healthy age-matched control participants. Participants observed and immediately imitated sequences showing a human hand reaching for and transferring an object between horizontal positions. Both groups significantly modulated their finger movements, showing higher vertical amplitude when imitating elevated compared to direct trajectories. In addition, movements were lower in vertical amplitude and higher in velocity when imitating the reaching segment than the transfer segment. Eye-tracking revealed that controls made smaller saccades when observing predictable than unpredictable elevated movements, but no effects of predictability on eye movements were found for the PD group. This study provides quantitative evidence that people with mild to moderate PD can imitate object-directed hand movement kinematics, although their prediction of such movements may be reduced. These findings suggest that interventions targeting object-directed actions may capitalize on the ability of people with PD to imitate kinematic parameters of a demonstrated movement. |
Carola Bloch; Shivakumar Viswanathan; Ralf Tepest; Mathis Jording; Christine M. Falter-Wagner; Kai Vogeley Differentiated, rather than shared, strategies for time-coordinated action in social and non-social domains in autistic individuals Journal Article In: Cortex, vol. 166, pp. 207–232, 2023. @article{Bloch2023, Autism spectrum disorder (ASD) is a neurodevelopmental condition with a highly heterogeneous adult phenotype that includes social and non-social behavioral characteristics. The link between the characteristics assignable to the different domains remains unresolved. One possibility is that social and non-social behaviors in autism are modulated by a common underlying deficit. However, here we report evidence supporting an alternative concept that is individual-centered rather than deficit-centered. Individuals are assumed to have a distinctive style in the strategies they adopt to perform social and non-social tasks with these styles presumably being structured differently between autistic individuals and typically-developed (TD) individuals. We tested this hypothesis for the execution of time-coordinated (synchronized) actions. Participants performed (i) a social task that required synchronized gaze and pointing actions to interact with another person, and (ii) a non-social task that required finger-tapping actions synchronized to periodic stimuli at different time-scales and sensory modalities. In both tasks, synchronization behavior differed between ASD and TD groups. However, a principal component analysis of individual behaviors across tasks revealed associations between social and non-social features for the TD persons but such cross–domain associations were strikingly absent for autistic individuals. The highly differentiated strategies between domains in ASD are inconsistent with a general synchronization deficit and instead highlight the individualized developmental heterogeneity in the acquisition of domain-specific behaviors. We propose a cognitive model to help disentangle individual-centered from deficit-centered effects in other domains. Our findings reinforce the importance to identify individually differentiated phenotypes to personalize autism therapies. |
Florence Blondiaux; Louisien Lebrun; Bernard J. Hanseeuw; Frédéric Crevecoeur Impairments of saccadic and reaching adaptation in essential tremor are linked to movement execution Journal Article In: Journal of Neurophysiology, vol. 130, no. 5, pp. 1092–1102, 2023. @article{Blondiaux2023, Essential tremor (ET) is a neurological disorder characterized by involuntary oscillations of the limbs. Previous studies have hypothesized that ET is a cerebellar disorder and reported impairments in motor adaptation. However, recent advances have highlighted that motor adaptation involves several components linked to anticipation and control, all dependent on cerebellum. We studied the contribution of both components in adaptation to better understand the adaptation impairments observed in ET from a behavioral perspective. To address this question, we investigated behavioral markers of adaptation in ET patients (n = 20) and age-matched neurologically intact volunteers (n = 20) in saccadic and upper limb adaptation tasks, probing compensation for target jumps and for velocity-dependent force fields, respectively. We found that both groups adapted their movements to the novel contexts; however, ET patients adapted to a lesser extent compared with neurologically intact volunteers. Importantly, components of the movement linked to anticipation were preserved in the ET group, whereas components linked to movement execution appeared responsible for the adaptation deficit in this group. Altogether, our results suggest that execution deficits may be a specific functional consequence of the alteration of neural pathways associated with ET.NEW & NOTEWORTHY We tested essential tremor patients' adaptation abilities in classical tasks including saccadic adaptation to target jumps and reaching adaptation to force field disturbances. Patients' adaptation was present but impaired in both tasks. Interestingly, the deficits were mainly present during movement execution, whereas the anticipatory components of movements were similar to neurologically intact volunteers. These findings reinforce the hypothesis of a cerebellar origin for essential tremor and detail the motor adaptation impairments previously found in this disorder. |
Zoé Bollen; Louise Kauffmann; Nathalie Guyader; Carole Peyrin; Pierre Maurage Does alcohol automatically capture drinkers' attention? Exploration through an eye-tracking saccadic choice task Journal Article In: Psychopharmacology, vol. 240, no. 2, pp. 271–282, 2023. @article{Bollen2023, Rationale: Dominant theoretical models postulate the presence of an automatic attentional bias (AB) towards alcohol-related stimuli in alcohol use disorder, such AB constituting a core feature of this disorder. An early alcohol AB has been documented in subclinical populations such as binge drinking (i.e., a drinking pattern prevalent in youth and characterized by repeated alternation between alcohol intoxications and withdrawals, generating cerebral consequences). However, the automatic nature of AB remains to be established. Objectives: We investigated the automatic nature of AB in binge drinkers through the saccadic choice task. This eye-tracking paradigm consistently highlights the extremely fast and involuntary saccadic responses elicited by faces in humans, relative to other object categories. Through an alcohol-related adaptation of the saccadic choice task, we tested whether the early and automatic capture of attentional resources elicited by faces can also be found for alcohol-related stimuli in binge drinkers, as predicted by theoretical models. Methods: Forty-three binge drinkers and 44 control participants performed two versions of the saccadic choice task. In the original version, two images (a face, a vehicle) were displayed on the left and right side of the screen respectively. Participants had to perform a saccade as fast as possible towards the target stimulus (either face or vehicle). In the alcohol-related version, the task was identical, but the images were an alcoholic beverage and a non-alcoholic stimulus. Results: We replicated the automatic attraction towards faces in both groups, as faces generated higher saccadic accuracy, speed, and amplitude than vehicles, as well as higher corrective saccade proportion. Concerning the alcohol-related adaptation of the task, groups did not differ for the accuracy, speed, and amplitude of the first saccade towards alcohol. However, binge drinkers differed from controls regarding the proportion of corrective saccade towards non-alcoholic stimuli after an error saccade towards alcohol, suggesting the presence of an alcohol disengagement bias specific to binge drinkers. Conclusions: Alcohol-related AB in binge drinkers is not characterized by an early and automatic hijacking of attention towards alcohol. This AB rather relies on later and more controlled processing stages, namely a difficulty to disengage attentional resources from alcohol-related stimuli. |
Zoé Bollen; Arthur Pabst; Nicolas Masson; Samuel Suárez-Suárez; Carina Carbia; Pierre Maurage Tell me how you feel, I will tell you what you look at: Impact of mood and craving on alcohol attentional bias in binge drinking Journal Article In: Journal of Psychopharmacology, vol. 37, no. 5, pp. 498–509, 2023. @article{Bollen2023a, Background: Alcohol-related attentional bias (AB) is thought to play a key role in the emergence and maintenance of excessive alcohol use. Recent models suggest that AB, classically considered as a permanent feature in alcohol use disorders, is rather modulated by temporary motivational states. Aims: We explored the influence of current mood and craving on AB in binge drinking, through a mood induction procedure combined with eye-tracking measures of AB. Methods: In Experiment 1, we measured AB (visual probe task with eye-tracking measures) among binge drinkers (n = 48) and light drinkers (n = 32) following positive, negative and neutral mood inductions. Participants reported subjective craving and mood before/after induction. In Experiment 2, we measured AB among the same binge drinkers compared with 29 moderate drinkers following alcohol-related negative, non-alcohol-related negative and neutral mood inductions. Results: In Experiment 1, induced negative mood and group positively predicted subjective craving, which was positively associated with AB. We found no effect of induced positive mood nor a direct mood-AB association. In Experiment 2, the relationships AB presented with both induced negative mood and group were again mediated by craving. Inducing alcohol-related negative mood did not modify the mood-craving association. Conclusions: Alcohol-related AB is not a stable binge drinking characteristic but rather varies according to transient motivational (i.e., craving) and emotional (i.e., negative mood) states. This study provides important insights to better understand AB in subclinical populations and emphasizes the importance of considering motivational and affective states as intercorrelated, to offer multiple ways to reduce excessive alcohol use. |
Lou Anne E. Boyd; Jazette Johnson; Franceli Cibrian; Deanna Hughes; Eliza Delpizzo-Cheng; Karen Lotich; Sara Jones; Hollis Pass; Viseth Sean; Gillian Hayes Global filter: Augmenting images to support seeing the "big picture" for people with local lnterference Journal Article In: ACM Transactions on Computer-Human Interaction, vol. 30, no. 3, pp. 1–28, 2023. @article{Boyd2023, Some neurodivergent people prioritize visual details over the "big picture". While excellent attention to detail has many advantages, some contexts require the rapid integration of global and local information. A local processing style can be so strong that local details interfere with the fluid integration of global information required for processing of information rapidly displayed on user interfaces. This disconnect between context of an interaction and processing style can be termed local interference. Personalization of visual stimuli can promote a more accessible computing experience. We describe how technological interventions can support shifting of visual attention from local to global features to make them more accessible. We present two empirical studies. One study with one autistic adult revealed a significant shift in eye gaze fixation, and the other study with 20 autistic children revealed filters that visually emphasize primary aspects encouraged more global comments about the image content. |
Laura B. Bragdon; Jacob A. Nota; Goi Khia Eng; Nicolette Recchia; Pearl Kravets; Katherine A. Collins; Emily R. Stern Failures of urge suppression in obsessive-compulsive disorder: Behavioral modeling using a blink suppression task Journal Article In: Journal of Obsessive-Compulsive and Related Disorders, vol. 38, pp. 1–10, 2023. @article{Bragdon2023, Many individuals with obsessive-compulsive disorder (OCD) report sensory-based urges (e.g. ‘not-just-right experiences') in addition to, or instead of, concrete fear-based obsessions. These sensations may be comparable to normative “urges-for-action” (UFA), such as the urge to blink. While research has identified altered functioning of brain regions related to UFA in OCD, little is known about behavioral patterns of urge suppression in the disorder. Using an urge-to-blink task as a model for sensory-based urges, this study compared failures of urge suppression between OCD patients and controls by measuring eyeblinks during 60-s blocks of instructed blink suppression. Cox shared frailty models estimated the hazard of first blinks during each 60-s block and recurrent blinks following each initial erroneous blink. OCD patients demonstrated a higher hazard of first and recurrent blinks compared to controls, suggesting greater difficulty resisting repetitive sensory-based urges. Within OCD, relationships between task outcomes and symptom severity were inconsistent. Findings provide support for a deficit in delaying initial urge-induced actions and terminating subsequent actions in OCD, which is not clearly related to clinical heterogeneity. Elucidating the nature of behavioral resistance to urges is relevant for informing conceptualizations of obsessive-compulsive psychopathology and optimizing treatment outcomes. |
Michael Paul Schallmo; Kimberly B. Weldon; Rohit S. Kamath; Hannah R. Moser; Samantha A. Montoya; Kyle W. Killebrew; Caroline Demro; Andrea N. Grant; Małgorzata Marjańska; Scott R. Sponheim; Cheryl A. Olman The psychosis human connectome project: Design and rationale for studies of visual neurophysiology Journal Article In: NeuroImage, vol. 272, pp. 1–20, 2023. @article{Schallmo2023, Visual perception is abnormal in psychotic disorders such as schizophrenia. In addition to hallucinations, laboratory tests show differences in fundamental visual processes including contrast sensitivity, center-surround interactions, and perceptual organization. A number of hypotheses have been proposed to explain visual dysfunction in psychotic disorders, including an imbalance between excitation and inhibition. However, the precise neural basis of abnormal visual perception in people with psychotic psychopathology (PwPP) remains unknown. Here, we describe the behavioral and 7 tesla MRI methods we used to interrogate visual neurophysiology in PwPP as part of the Psychosis Human Connectome Project (HCP). In addition to PwPP (n = 66) and healthy controls (n = 43), we also recruited first-degree biological relatives (n = 44) in order to examine the role of genetic liability for psychosis in visual perception. Our visual tasks were designed to assess fundamental visual processes in PwPP, whereas MR spectroscopy enabled us to examine neurochemistry, including excitatory and inhibitory markers. We show that it is feasible to collect high-quality data across multiple psychophysical, functional MRI, and MR spectroscopy experiments with a sizable number of participants at a single research site. These data, in addition to those from our previously described 3 tesla experiments, will be made publicly available in order to facilitate further investigations by other research groups. By combining visual neuroscience techniques and HCP brain imaging methods, our experiments offer new opportunities to investigate the neural basis of abnormal visual perception in PwPP. |
Eser Sendesen; Samet Kılıç; Nurhan Erbil; Özgür Aydın; Didem Turkyilmaz An exploratory study of the effect of tinnitus on listening effort using EEG and pupillometry Journal Article In: Otolaryngology-Head and Neck Surgery, vol. 169, no. 5, pp. 1259–1267, 2023. @article{Sendesen2023, Objective: Previous behavioral studies on listening effort in tinnitus patients did not consider extended high-frequency hearing thresholds and had conflicting results. This inconsistency may be related that listening effort is not evaluated by the central nervous system (CNS) and autonomic nervous system (ANS), which are directly related to tinnitus pathophysiology. This study matches hearing thresholds at all frequencies, including the extended high-frequency and reduces hearing loss to objectively evaluate listening effort over the CNS and ANS simultaneously in tinnitus patients. Study Design: Case-control study. Setting: University hospital. Methods: Sixteen chronic tinnitus patients and 23 matched healthy controls having normal pure-tone averages with symmetrical hearing thresholds were included. Subjects were evaluated with 0.125 to 20 kHz pure-tone audiometry, Montreal Cognitive Assessment Test (MoCA), Tinnitus Handicap Inventory (THI), Visual Analog Scale (VAS), electroencephalography (EEG), and pupillometry. Results: Pupil dilation and EEG alpha band in the “coding” phase of the sentence presented in tinnitus patients was less than in the control group (p <.05). VAS score was higher in the tinnitus group (p <.01). Also, there was no statistically significant relationship between EEG and pupillometry components and THI or MoCA (p >.05). Conclusion: This study suggests that tinnitus patients may need to make an extra effort to listen. Also, pupillometry may not be sufficiently reliable to assess listening effort in ANS-related pathologies. Considering the possible listening difficulties in tinnitus patients, reducing the listening difficulties, especially in noisy environments, can be added to the goals of tinnitus therapy protocols. |
Mishaal Sharif; Yougan Saman; Rose Burling; Oliver Rea; Rakesh Patel; Douglas J. K. Barrett; Peter Rea; Amir Kheradmand; Qadeer Arshad Altered visual conscious awareness in patients with vestibular dysfunctions; a cross-sectional observation study Journal Article In: Journal of the Neurological Sciences, vol. 448, pp. 1–6, 2023. @article{Sharif2023, Background: Patients with vestibular dysfunctions often experience visual-induced symptoms. Here we asked whether such visual dependence can be related to alterations in visual conscious awareness in these patients. Methods: To measure visual conscious awareness, we used the effect of motion-induced blindness (MIB,) in which the perceptual awareness of the visual stimulus alternates despite its unchanged physical characteristics. In this phenomenon, a salient visual target spontaneously disappears and subsequently reappears from visual perception when presented against a moving visual background. The number of perceptual switches during the experience of the MIB stimulus was measured for 120 s in 15 healthy controls, 15 patients with vestibular migraine, 15 patients with benign positional paroxysmal vertigo (BPPV) and 15 with migraine without vestibular symptoms. Results: Patients with vestibular dysfunctions (i.e., both vestibular migraine and BPPV) exhibited increased perceptual fluctuations during MIB compared to healthy controls and migraine patients without vertigo. In VM patients, those with more severe symptoms exhibited higher fluctuations of visual awareness (i.e., positive correlation), whereas, in BPPV patients, those with more severe symptoms had lower fluctuations of visual awareness (i.e., negative correlation). Implications: Taken together, these findings show that fluctuations of visual awareness are linked to the severity of visual-induced symptoms in patients with vestibular dysfunctions, and distinct pathophysiological mechanisms may mediate visual vertigo in peripheral versus central vestibular dysfunctions. |
Tarkeshwar Singh; John-Ross Rizzo; Cédrick Bonnet; Jennifer A. Semrau; Troy M. Herter Enhanced cognitive interference during visuomotor tasks may cause eye–hand dyscoordination Journal Article In: Experimental Brain Research, vol. 241, no. 2, pp. 547–558, 2023. @article{Singh2023, In complex visuomotor tasks, such as cooking, people make many saccades to continuously search for items before and during reaching movements. These tasks require cognitive resources, such as short-term memory and task-switching. Cognitive load may impact limb motor performance by increasing demands on mental processes, but mechanisms remain unclear. The Trail-Making Tests, in which participants sequentially search for and make reaching movements to 25 targets, consist of a simple numeric variant (Trails-A) and a cognitively challenging variant that requires alphanumeric switching (Trails-B). We have previously shown that stroke survivors and age-matched controls make many more saccades in Trails-B, and those increases in saccades are associated with decreases in speed and smoothness of reaching movements. However, it remains unclear how patients with neurological injuries, e.g., stroke, manage progressive increases in cognitive load during visuomotor tasks, such as the Trail-Making Tests. As Trails-B trial progresses, switching between numbers and letters leads to progressive increases in cognitive load. Here, we show that stroke survivors with damage to frontoparietal areas and age-matched controls made more saccades and had longer fixations as they progressed through the 25 alphanumeric targets in Trails-B. Furthermore, when stroke survivors made saccades during reaching movements in Trails-B, their movement speed slowed down significantly. Thus, damage to frontoparietal areas serving cognitive motor functions may cause interference between oculomotor, visual, and limb motor functions, which could lead to significant disruptions in activities of daily living. These findings augment our understanding of the mechanisms that underpin cognitive-motor interference during complex visuomotor tasks. |
Emma J. Solly; Meaghan Clough; Allison M. McKendrick; Owen B. White; Joanne Fielding Eye movement characteristics are not significantly influenced by psychiatric comorbidities in people with visual snow syndrome Journal Article In: Brain Research, vol. 1804, pp. 1–5, 2023. @article{Solly2023, Visual snow syndrome (VSS) is a neurological disorder primarily affecting the processing of visual information. Using ocular motor (OM) tasks, we previously demonstrated that participants with VSS exhibit altered saccade profiles consistent with visual attention impairments. We subsequently proposed that OM assessments may provide an objective measure of dysfunction in these individuals. However, VSS participants also frequently report significant psychiatric symptoms. Given that that these symptoms have been shown previously to influence performance on OM tasks, the objective of this study was to investigate whether psychiatric symptoms (specifically: depression, anxiety, fatigue, sleep difficulties, and depersonalization) influence the OM metrics found to differ in VSS. Sixty-one VSS participants completed a battery of four OM tasks and a series of online questionnaires assessing psychiatric symptomology. We revealed no significant relationship between psychiatric symptoms and OM metrics on any of the tasks, demonstrating that in participants with VSS, differences in OM behaviour are a feature of the disorder. This supports the utility of OM assessment in characterising deficit in VSS, whether supporting a diagnosis or monitoring future treatment efficacy. |
Anna Cornelia Stausberg Who are you to judge? Investigating narcissism through pupil dilation at witness testimonials Journal Article In: Psychology, vol. 14, no. 02, pp. 144–157, 2023. @article{Stausberg2023, Various literature has explored narcissistic behaviour and its distinct emotional and aggressive nature. However, there is a significant gap in research when exploring the physiological differences of individual classified as having high narcissistic traits and tendencies. Pupillometry is a measure often utilised to measure distinct differences in emotional arousal. This measure allows for excellent insight into physiological responses to various stimuli presented. This exploratory study was set up to investigate pupillometry responses to auditory stimulation in narcissistic versus control participants. Findings were consistent with previous research; however, various limitations hindered significant findings. This pilot study is a guideline for future research as it is a first attempt at exploring a physiological relationship between emotionality and narcissism in the context of a criminal hearing. |
Pnina Stern; Tamar Kolodny; Shlomit Tsafrir; Galit Cohen; Lilach Shalev In: Journal of Attention Disorders, vol. 27, no. 7, pp. 757–776, 2023. @article{Stern2023, Objective: The present study evaluated the near (attention) and far (reading, ADHD symptoms, learning, and quality of life) transfer effects of a Computerized Progressive Attention Training (CPAT) versus Mindfulness Based Stress Reduction (MBSR) practice among adults with ADHD compared to a passive group. Method: Fifty-four adults participated in a non-fully randomized controlled trial. Participants in the intervention groups completed eight 2-hr weekly training sessions. Outcomes were assessed before, immediately after, and 4 months post-intervention, using objective tools: attention tests, eye-tracker, and subjective questionnaires. Results: Both interventions showed near-transfer to various attention functions. The CPAT produced far-transfer effects to reading, ADHD symptoms, and learning while the MBSR improved the self-perceived quality of life. At follow-up, all improvements except for ADHD symptoms were preserved in the CPAT group. The MBSR group showed mixed preservations. Conclusion: Both interventions have beneficial effects, however only the CPAT group exhibited improvements compared to the passive group. |
Benjamin Suarez-Jimenez; Amit Lazarov; Xi Zhu; Daniel S. Pine; Yair Bar-Haim; Yuval Neria Attention allocation to negatively-valenced stimuli in PTSD is associated with reward-related neural pathways Journal Article In: Psychological Medicine, vol. 53, no. 10, pp. 4666–4674, 2023. @article{SuarezJimenez2023, Background. In a recent eye-tracking study we found a differential dwell time pattern for negatively-valenced and neutral faces among patients with posttraumatic stress disorder (PTSD), trauma-exposed healthy control (TEHCs), and healthy control (HC) participants. Here, we explored whether these group differences relate to resting-state functional connectivity (rsFC) patterns of brain areas previously linked to both attention processes and PTSD. These encompass the amygdala, dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), and nucleus accumbens (NAcc).Methods.Ten minutes magnetic resonance imaging rsFC scans were recorded in 17 PTSD patients, 21 TEHCs, and 16 HCs. Participants then completed a free-viewing eye-tracking task assessing attention allocation outside the scanner. Dwell time on negatively-valenced stimuli (DT%) were assessed relative to functional connectivity in the aforementioned seed regions of interest (amygdala, dACC, dlPFC, vlPFC, and NAcc) to whole-brain voxel-wise rsFC.Results. As previously reported, group differences occurred in attention allocation to negative-valence stimuli, with longer dwell time on negatively valence stimuli in the PTSD and TEHC groups than the HC group. Higher DT% correlated with weaker NAcc-orbitofrontal cortex (OFC) connectivity in patients with PTSD. Conversely, a positive association emerged in the HC group between DT% and NAcc-OFC connectivity.Conclusions. While exploratory in nature, present findings may suggest that reward-related brain areas are involved in disengaging attention from negative-valenced stimuli, and possibly in regulating ensuing negative emotions. |
Sai Sun; Runnan Cao; Ueli Rutishauser; Rongjun Yu; Shuo Wang A uniform human multimodal dataset for emotion perception and judgment Journal Article In: Scientific Data, vol. 10, no. 1, pp. 1–14, 2023. @article{Sun2023c, Face perception is a fundamental aspect of human social interaction, yet most research on this topic has focused on single modalities and specific aspects of face perception. Here, we present a comprehensive multimodal dataset for examining facial emotion perception and judgment. This dataset includes EEG data from 97 unique neurotypical participants across 8 experiments, fMRI data from 19 neurotypical participants, single-neuron data from 16 neurosurgical patients (22 sessions), eye tracking data from 24 neurotypical participants, behavioral and eye tracking data from 18 participants with ASD and 15 matched controls, and behavioral data from 3 rare patients with focal bilateral amygdala lesions. Notably, participants from all modalities performed the same task. Overall, this multimodal dataset provides a comprehensive exploration of facial emotion perception, emphasizing the importance of integrating multiple modalities to gain a holistic understanding of this complex cognitive process. This dataset serves as a key missing link between human neuroimaging and neurophysiology literature, and facilitates the study of neuropsychiatric populations. |
Georgia F. Symons; William T. O'Brien; Larry Abel; Zhibin Chen; Daniel M. Costello; Terence J. O'Brien; Scott Kolbe; Joanne Fielding; Sandy R. Shultz; Meaghan Clough; William T. O'Brien; Larry Abel; Zhibin Chen; Daniel M. Costello; Terence J. O'brien; Scott Kolbe; Joanne Fielding; Sandy R. Shultz; Meaghan Clough Monitoring the acute and subacute recovery of cognitive ocular motor changes after a sports-related concussion Journal Article In: Cerebral Cortex, vol. 33, no. 9, pp. 5276–5288, 2023. @article{Symons2023, Identifying when recovery from a sports-related concussion (SRC) has occurred remains a challenge in clinical practice. This study investigated the utility of ocular motor (OM) assessment to monitor recovery post-SRC between sexes and compared to common clinical measures. From 139 preseason baseline assessments (i.e. before they sustained an SRC), 18 (12 males, 6 females) consequent SRCs were sustained and the longitudinal follow-ups were collected at 2, 6, and 13 days post-SRC. Participants completed visually guided, antisaccade (AS), and memory-guided saccade tasks requiring a saccade toward, away from, and to a remembered target, respectively. Changes in latency (processing speed), visual-spatial accuracy, and errors were measured. Clinical measures included The Sports Concussion Assessment Tool, King-Devick test, Stroop task, and Digit span. AS latency was significantly longer at 2 days and returned to baseline by 13-days post-SRC in females only (P < 0.001). Symptom numbers recovered from 2 to 6 days and 13 days (P < 0.05). Persistently poorer AS visual-spatial accuracy was identified at 2, 6 and 13 days post-SRC (P < 0.05) in both males and females but with differing trajectories. Clinical measures demonstrated consistent improvement reminiscent of practice effects. OM saccade assessment may have improved utility in tracking recovery compared to conventional measures and between sexes. |
Yasuo Terao; Shin-ichi Tokushige; Satomi Inomata-Terada; Tai Miyazaki; Naoki Kotsuki; Francesco Fisicaro; Yoshikazu Ugawa How do patients with Parkinson's disease and cerebellar ataxia read aloud? -Eye–voice coordination in text reading Journal Article In: Frontiers in Neuroscience, vol. 17, pp. 1–25, 2023. @article{Terao2023a, Background: The coordination between gaze and voice is closely linked when reading text aloud, with the gaze leading the reading position by a certain eye–voice lead (EVL). How this coordination is affected is unknown in patients with cerebellar ataxia and parkinsonism, who show oculomotor deficits possibly impacting coordination between different effectors. Objective: To elucidate the role of the cerebellum and basal ganglia in eye–voice coordination during reading aloud, by studying patients with Parkinson's disease (PD) and spinocerebellar degeneration (SCD). Methods: Participants were sixteen SCD patients, 18 PD patients, and 30 age-matched normal subjects, all native Japanese speakers without cognitive impairment. Subjects read aloud Japanese texts of varying readability displayed on a monitor in front of their eyes, consisting of Chinese characters and hiragana (Japanese phonograms). The gaze and voice reading the text was simultaneously recorded by video-oculography and a microphone. A custom program synchronized and aligned the gaze and audio data in time. Results: Reading speed was significantly reduced in SCD patients (3.53 ± 1.81 letters/s), requiring frequent regressions to compensate for the slow reading speed. In contrast, PD patients read at a comparable speed to normal subjects (4.79 ± 3.13 letters/s vs. 4.71 ± 2.38 letters/s). The gaze scanning speed, excluding regressive saccades, was slower in PD patients (9.64 ± 4.26 letters/s) compared to both normal subjects (12.55 ± 5.42 letters/s) and SCD patients (10.81 ± 4.52 letters/s). PD patients' gaze could not far exceed that of the reading speed, with smaller allowance for the gaze to proceed ahead of the reading position. Spatial EVL was similar across the three groups for all texts (normal: 2.95 ± 1.17 letters/s, PD: 2.95 ± 1.51 letters/s, SCD: 3.21 ± 1.35 letters/s). The ratio of gaze duration to temporal EVL was lowest for SCD patients (normal: 0.73 ± 0.50, PD: 0.70 ± 0.37, SCD: 0.40 ± 0.15). Conclusion: Although coordination between voice and eye movements and normal eye-voice span was observed in both PD and SCD, SCD patients made frequent regressions to manage the slowed vocal output, restricting the ability for advance processing of text ahead of the gaze. In contrast, PD patients experience restricted reading speed primarily due to slowed scanning, limiting their maximum reading speed but effectively utilizing advance processing of upcoming text. |
Carolin Zsigo; Lisa Feldmann; Frans Oort; Charlotte Piechaczek; Jürgen Bartling; Martin Schulte-Rüther; Christian Wachinger; Gerd Schulte-Körne; Ellen Greimel Emotion regulation training for adolescents with major depression: Results from a randomized controlled trial Journal Article In: Emotion, pp. 1–18, 2023. @article{Zsigo2023, Difficulties in emotion regulation (ER) are thought to contribute to the development and maintenance of major depression (MD) in adolescents. In healthy adults, a task-based training of ER has previously proven effective to reduce stress, but no such studies are available for MD. It is also unclear whether findings can be generalized onto adolescent populations. The final sample consisted of n = 70 adolescents with MD, who were randomized to a task-based ER training (n = 36) or a control training (n = 34). Across four sessions, the ER group was trained to downregulate negative affect to negative images via reappraisal, while the control group was instructed to attend the images. Rumination, stress-, and affect-related measures were assessed as primary outcomes, behavioral and neurophysiological responses (late positive potential, LPP), as secondary outcomes. The trial was preregistered at clinicaltrials.gov (NCT03957850). While there was no significant differential effect of the ER training on primary outcomes, we found small to moderate effects on rumination in the ER group, but not the control group. During reappraisal (compared to attend), the ER group showed an unexpected increase of the LPP during the first, but not during later training sessions. Although replication in large, multicenter trials is needed, our findings on effect sizes suggest that ER training might be promising to decrease rumination in adolescent MD. The LPP increase at the first session may represent cognitive effort, which was successfully reduced over the sessions. Future studies should research whether training effects transfer to daily life and are durable over a longer time period. (PsycInfo Database Record (c) 2023 APA, all rights reserved) |
Mengran Xu; Katelyn Rowe; Christine Purdon To approach or to avoid: The role of ambivalent motivation towards high calorie food images in restrained eaters Journal Article In: Cognitive Therapy and Research, vol. 47, no. 4, pp. 669–680, 2023. @article{Xu2023b, Background: Individuals who engage in restrained eating are often torn between eating enjoyment and weight control. Recent research found visual attention to threat varied according to motivation, and people with ambivalent motivation about threat showed greater anxiety. Methods: A total number of 225 individuals high in restrained eating completed a passive viewing task in which they were presented with image pairs of high calorie food and neutral objects while their eye movements were tracked. Participants also rated their motivation to look towards and away from food images and completed measures of mood and thought-shape fusion. Results: Two-thirds of participants reported strong motivation to look at food images, and the rest were highly motivated to avoid, were indifferent, or were ambivalent. Visual attention to food images varied according to motivation. Ambivalent individuals had higher thought-shape fusion scores and were more restrained in their eating than engagers and indifferent individuals. Conclusions: These findings suggest that motivation to attend to and avoid food images are important factors to study, as they are associated with attentional biases and eating pathology. Clinical implications are also discussed. |
Pei Xie; Han-Bin Sang; Chao-Zheng Huang; Ai-Bao Zhou Effect of body-related information on food attentional bias in women with body weight dissatisfaction Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 1–10, 2023. @article{Xie2023, Women with body weight dissatisfaction (BWD) have long-term negative assessments of their body weight, which are often associated with poor eating behavior. In this study, we investigated the effect of body-related information on the food cue processing and attention of women with BWD. Sixty-eight women were recruited and assigned to either a BWD (NPSS-F > 2) (n = 32) or a no body weight dissatisfaction (NBWD) group (NPSS-F < 1) (n = 36). We measured attentional bias to food cues (high- and low-calorie) with a food probe task after exposure to body-related information and recorded eye tracking data. Body-related images were presented prior to a pair of stimulus images (food–neutral or neutral–neutral). Body-related information and food type were repeated measure factors in our study. Our results showed that the first fixation duration bias for high-calorie foods was significantly longer than for low-calorie foods after exposure to overweight cues in the BWD group. Compared with the NBWD group, the BWD group showed longer first fixation duration bias for high-calorie foods after exposure to overweight cues. The direction for high-calorie foods was significantly more often than that for low-calorie foods in the BWD group after exposure to body-related information. Our findings suggest that compared to women with NBWD, women with BWD may be more susceptible to body-related information, resulting in increased attention to high-calorie foods. |
Junru Wu; Min Li; Wenbo Ma; Zhihao Zhang; Mingsha Zhang; Xuemei Li In: Gerontology, vol. 69, no. 3, pp. 321–335, 2023. @article{Wu2023d, Background: Among the elderly, dementia is a common and disabling disorder with primary manifestations of cognitive impairments. Diagnosis and intervention in its early stages is the key to effective treatment. Nowadays, the test of cognitive function relies mainly on neuropsychological tests, such as the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). However, they have noticeable shortcomings, e.g., the biases of subjective judgments from physicians and the cost of the labor of these well-trained physicians. Thus, advanced and objective methods are urgently needed to evaluate cognitive functions. Methods: We developed a cognitive assessment system through measuring the saccadic eye movements in three tasks. The cognitive functions were evaluated by both our system and the neuropsychological tests in 310 subjects, and the evaluating results were directly compared. Results: In general, most saccadic parameters correlate well with the MMSE and MoCA scores. Moreover, some subjects with high MMSE and MoCA scores have high error rates in performing these three saccadic tasks due to various errors. The primary error types vary among tasks, indicating that different tasks assess certain specific brain functions preferentially. Thus, to improve the accuracy of evaluation through saccadic tasks, we built a weighted model to combine the saccadic parameters of the three saccadic tasks, and our model showed a good diagnosis performance in detecting patients with cognitive impairment. Conclusion: The comprehensive analysis of saccadic parameters in multiple tasks could be a reliable, objective, and sensitive method to evaluate cognitive function and thus to help diagnose cognitive impairments. |
Chaoqing Yang; Linlin He; Yucheng Liu; Ziyang Lin; Lizhu Luo; Shan Gao Anti-saccades reveal impaired attention control over negative social evaluation in individuals with depressive symptoms Journal Article In: Journal of Psychiatric Research, vol. 165, pp. 64–69, 2023. @article{Yang2023, Depressed individuals are excessively sensitive to negative information but blunt to positive information, which has been considered as vulnerability to depression. Here, we focused on inhibitory control over attentional bias on social evaluation in individuals with depression. We engaged individuals with and without depressive symptoms (categorized by Beck Depression Inventory-II) in a novel attention control task using positive and negative evaluative adjectives as self-referential feedback given by social others. Participants were instructed to look at sudden onset feedback targets (pro-saccade) or the mirror location of the targets (anti-saccade) when correct saccade latencies and saccade errors were collected. The two indices showed that while both groups displayed longer latencies and more errors for anti-saccade relative to pro-saccade responses depressed individuals spent more time reacting correctly and made more errors than non-depressed individuals in the anti-saccade trials and such group differences were not observed in the pro-saccade trials. Although group differences in correct anti-saccade latencies were found for both positive and negative stimuli, depressed individuals spent more time making correct anti-saccade responses to negative social feedback than to positive ones whereas non-depressed individuals featured longer correct anti-saccade latencies for positive relative to negative evaluations. Our results suggest that depressed individuals feature an impaired ability in attention control for self-referential evaluations, notably those of negative valence, shedding new light on depression-distorted self-schema and corresponding social dysfunctions. |
Ji Su Yeon; Ha Na Jung; Jae-Young Kim; Kyong In Jung; Hae Young Lopilly Park; Chan Kee Park; Hyo Won Kim; Man Soo Kim; Yong Chan Kim Deviated saccadic trajectory as a biometric signature of glaucoma Journal Article In: Translational Vision Science & Technology, vol. 12, no. 7, pp. 1–12, 2023. @article{Yeon2023, Purpose: To investigate whether the trajectories of saccadic eye movements (SEMs) significantly differ between glaucoma patients and controls. Methods: SEMs were recorded by video-based infrared oculography in 53 patients with glaucoma and 41 age-matched controls. Participants were asked to bilaterally view 24°-horizontal, 14°-vertical, and 20°-diagonal eccentric Goldmann III-sized stimuli. SEMs were evaluated with respect to the saccadic reaction time (SRT), the mean velocity, amplitude, and two novel measures: departure angle (DA) and arrival angle (AA). These parameters were compared between the groups and the associations of SEM parameters with glaucoma parameters and integrated visual field defects were investigated. Results: Glaucoma patients exhibited increased mean SRT, DA, and AA values compared with controls for 14°-vertical visual targets (P = 0.05, P < 0.01, and P < 0.01, respectively). The SRT, DA, and AA were significantly associated with the mean and pattern standard deviations of perimetry and with the mean RNFL thickness by OCT (all P < 0.001). Glaucoma was associated with the AA (P = 0.05) and both the SRT (P = 0.01) and DA (P = 0.04) were associated with integrated visual field defects. Conclusions: The saccadic trajectories of glaucoma patients depart in an erroneous path and compensate the disparity by deviating the trajectory at arrival. Translational Relevance: The initial deviation that we observed (despite continuous exposure to the stimulus) suggests the disoriented spatial perception of glaucoma patients which may be relevant to difficulties encountered daily. |
Dan Zhang; Lihua Xu; Yuou Xie; Xiaochen Tang; Yegang Hu; Xu Liu; Guisen Wu; Zhenying Qian; Yingying Tang; Zhi Liu; Tao Chen; HaiChun Liu; Tianhong Zhang; Jijun Wang Eye movement indices as predictors of conversion to psychosis in individuals at clinical high risk Journal Article In: European Archives of Psychiatry and Clinical Neuroscience, vol. 273, no. 3, pp. 553–563, 2023. @article{Zhang2023i, Eye movement abnormalities have been established as an “endophenotype” of schizophrenia. However, less is known about the possibility of these abnormalities as biomarkers for psychosis conversion among clinical high risk (CHR) populations. In the present study, 108 CHR individuals and 70 healthy controls (HC) underwent clinical assessments and eye-tracking tests, comprising fixation stability and free-viewing tasks. According to three-year follow-up outcomes, CHR participants were further stratified into CHR-converter (CHR-C; n = 21) and CHR-nonconverter (CHR-NC; n = 87) subgroups. Prediction models were constructed using Cox regression and logistic regression. The CHR-C group showed more saccades of the fixation stability test (no distractor) and a reduced saccade amplitude of the free-viewing test than HC. Moreover, the CHR-NC group exhibited excessive saccades and an increased saccade amplitude of the fixation stability test (no distractor; with distractor) compared with HC. Furthermore, two indices could effectively discriminate CHR-C from CHR-NC with an area under the receiver-operating characteristic (ROC) curve of 0.80, including the saccade number of the fixation stability test (no distractor) and the saccade amplitude of the free-viewing test. Combined with negative symptom scores of the Scale of Prodromal Symptoms, the area was 0.81. These findings support that eye movement alterations might emerge before the onset of clinically overt psychosis and could assist in predicting psychosis transition among CHR populations. |
Hanna E. Willis; I. Betina Ip; Archie Watt; Jon Campbell; Saad Jbabdi; William T. Clarke; Matthew R. Cavanaugh; Krystel R. Huxlin; Kate E. Watkins; Marco Tamietto; Holly Bridge GABA and glutamate in hMT+ link to individual differences in residual visual function after occipital stroke Journal Article In: Stroke, vol. 54, no. 9, pp. 2286–2295, 2023. @article{Willis2023, BACKGROUND: Damage to the primary visual cortex following an occipital stroke causes loss of conscious vision in the contralateral hemifield. Yet, some patients retain the ability to detect moving visual stimuli within their blind field. The present study asked whether such individual differences in blind field perception following loss of primary visual cortex could be explained by the concentration of neurotransmitters γ-aminobutyric acid (GABA) and glutamate or activity of the visual motion processing, human middle temporal complex (hMT+). METHODS: We used magnetic resonance imaging in 19 patients with chronic occipital stroke to measure the concentration of neurotransmitters GABA and glutamate (proton magnetic resonance spectroscopy) and functional activity in hMT+ (functional magnetic resonance imaging). We also tested each participant on a 2-interval forced choice detection task using high-contrast, moving Gabor patches. We then measured and assessed the strength of relationships between participants' residual vision in their blind field and in vivo neurotransmitter concentrations, as well as visually evoked functional magnetic resonance imaging activity in their hMT+. Levels of GABA and glutamate were also measured in a sensorimotor region, which served as a control. RESULTS: Magnetic resonance spectroscopy-derived GABA and glutamate concentrations in hMT+ (but not sensorimotor cortex) strongly predicted blind-field visual detection abilities. Performance was inversely related to levels of both inhibitory and excitatory neurotransmitters in hMT+ but, surprisingly, did not correlate with visually evoked blood oxygenation level-dependent signal change in this motion-sensitive region. CONCLUSIONS: Levels of GABA and glutamate in hMT+ appear to provide superior information about motion detection capabilities inside perimetrically defined blind fields compared to blood oxygenation level-dependent signal changes - in essence, serving as biomarkers for the quality of residual visual processing in the blind-field. Whether they also reflect a potential for successful rehabilitation of visual function remains to be determined. |
Qiong Zhang; Weifeng Sun; Kailing Huang; Li Qin; Shirui Wen; Xiaoyan Long; Quan Wang; Li Feng Frontal lobe epilepsy: An eye tracking study of memory and attention Journal Article In: Frontiers in Neuroscience, vol. 17, pp. 1–11, 2023. @article{Zhang2023c, Objective: To explore the characteristics and mechanisms of working memory impairment in patients with frontal lobe epilepsy (FLE) through a memory game paradigm combined with eye tracking technology. Method: We included 44 patients with FLE and 50 healthy controls (HC). All participants completed a series of neuropsychological scale assessments and a short-term memory game on an automated computer-based memory evaluation platform with an eye tracker. Results: Memory scale scores of FLE patients including digit span (U = 747.50 |
Veronica Whitford; Narissa Byers; Gillian A. O'Driscoll; Debra Titone Eye movements and the perceptual span in disordered reading: A comparison of schizophrenia and dyslexia Journal Article In: Schizophrenia Research: Cognition, vol. 34, pp. 1–13, 2023. @article{Whitford2023, Increasing evidence of a common neurodevelopmental etiology between schizophrenia and developmental dyslexia suggests that neurocognitive functions, such as reading, may be similarly disrupted. However, direct comparisons of reading performance in these disorders have yet to be conducted. To address this gap in the literature, we employed a gaze-contingent moving window paradigm to examine sentence-level reading fluency and perceptual span (breadth of parafoveal processing) in adults with schizophrenia (dataset from Whitford et al., 2013) and psychiatrically healthy adults with dyslexia (newly collected dataset). We found that the schizophrenia and dyslexia groups exhibited similar reductions in sentence-level reading fluency (e.g., slower reading rates, more regressions) compared to matched controls. Similar reductions were also found for standardized language/reading and executive functioning measures. However, despite these reductions, the dyslexia group exhibited a larger perceptual span (greater parafoveal processing) than the schizophrenia group, potentially reflecting a disruption in normal foveal-parafoveal processing dynamics. Taken together, our findings suggest that reading and reading-related functions are largely similarly disrupted in schizophrenia and dyslexia, providing additional support for a common neurodevelopmental etiology. |
Mirjam C. M. Wever; Lisanne A. E. M. Houtum; Loes H. C. Janssen; Wilma G. M. Wentholt; Iris M. Spruit; Marieke S. Tollenaar; Geert Jan Will; Bernet M. Elzinga In: Cognitive, Affective, & Behavioral Neuroscience, vol. 23, no. 6, pp. 1598–1609, 2023. @article{Wever2023, One of the most prevalent nonverbal, social phenomena known to automatically elicit self- and other-referential processes is eye contact. By its negative effects on the perception of social safety and views about the self and others, childhood emotional maltreatment (CEM) may fundamentally affect these processes. To investigate whether the socioaffective consequences of CEM may become visible in response to (prolonged) eye gaze, 79 adult participants (mean [M]age = 49.87, standard deviation [SD]age = 4.62) viewed videos with direct and averted gaze of an unfamiliar other and themselves while we recorded self-reported mood, eye movements using eye-tracking, and markers of neural activity using fMRI. Participants who reported higher levels of CEM exhibited increased activity in ventromedial prefrontal cortex to one's own, but not to others', direct gaze. Furthermore, in contrast to those who reported fewer of such experiences, they did not report a better mood in response to a direct gaze of self and others, despite equivalent amounts of time spent looking into their own and other peoples' eyes. The fact that CEM is associated with enhanced neural activation in a brain area that is crucially involved in self-referential processing (i.e., vmPFC) in response to one's own direct gaze is in line with the chronic negative impact of CEM on a person's self-views. Interventions that directly focus on targeting maladaptive self-views elicited during eye gaze to self may be clinically useful. |
Junyi Zhou; Zhanshuang Bai In: Frontiers in Psychology, vol. 14, pp. 1–8, 2023. @article{Zhou2023, Introduction: Previous studies have shown that brief moderate-intensity aerobic exercise can improve the executive function of healthy adults. The present study sought to examine and compare the effects of brief moderate-intensity aerobic exercise on the executive functions of undergraduates with and without mobile phone addiction. Method: Thirty-two healthy undergraduates with mobile phone addiction were recruited and randomly assigned to either an exercise or control group. Likewise, 32 healthy undergraduates without mobile phone addiction were recruited and randomly assigned to either an exercise or control group. Participants were asked to perform moderate-intensity aerobic exercise for 15 minutes for the exercise groups. The executive functions of all participants were assessed via the antisaccade task twice (i.e., pre-test and post-test). Results: The results showed that the saccade latency, variability of saccade latency, and error rate decreased significantly from pre-test to post-test for all participants. More importantly, after the 15-min moderate-intensity aerobic exercise intervention, participants in the exercise groups showed significantly shorter saccade latency than their counterparts in the control groups, regardless of whether they are with mobile phone addiction. Discussion: This result is consistent with previous studies demonstrating that brief moderate-intensity aerobic exercise can improve one's executive function. Furthermore, the absence of significant interaction among Time, Group, and Intervention implies that the effects of brief moderate-intensity aerobic exercise on executive function are comparable between participants with and without mobile phone addiction. The present study supports the previous conclusion that brief moderate-intensity aerobic exercise can improve one's executive function effectively, and extends it to the population with mobile phone addiction. In summary, the present study has some implications for understanding of the relationship between exercise, executive function, and mobile phone addiction. |
Anastasia A. Ziubanova; Anna K. Laurinavichyute; Olga Parshina Does early exposure to spoken and sign language affect reading fluency in deaf and hard-of-hearing adult signers? Journal Article In: Frontiers in Psychology, vol. 14, pp. 1–9, 2023. @article{Ziubanova2023, Introduction: Early linguistic background, and in particular, access to language, lays the foundation of future reading skills in deaf and hard-of-hearing signers. The current study aims to estimate the impact of two factors – early access to sign and/or spoken language – on reading fluency in deaf and hard-of-hearing adult Russian Sign Language speakers. Methods: In the eye-tracking experiment, 26 deaf and 14 hard-of-hearing native Russian Sign Language speakers read 144 sentences from the Russian Sentence Corpus. Analysis of global eye-movement trajectories (scanpaths) was used to identify clusters of typical reading trajectories. The role of early access to sign and spoken language as well as vocabulary size as predictors of the more fluent reading pattern was tested. Results: Hard-of-hearing signers with early access to sign language read more fluently than those who were exposed to sign language later in life or deaf signers without access to speech sounds. No association between early access to spoken language and reading fluency was found. Discussion: Our results suggest a unique advantage for the hard-of-hearing individuals from having early access to both sign and spoken language and support the existing claims that early exposure to sign language is beneficial not only for deaf but also for hard-of-hearing children. |
Xi Zhu; Amit Lazarov; Sarah Dolan; Yair Bar-Haim; Daniel G. Dillon; Diego A. Pizzagalli; Franklin Schneier Resting state connectivity predictors of symptom change during gaze-contingent music reward therapy of social anxiety disorder Journal Article In: Psychological Medicine, vol. 53, no. 7, pp. 3115–3123, 2023. @article{Zhu2023a, Background Social anxiety disorder (SAD) is common, first-line treatments are often only partially effective, and reliable predictors of treatment response are lacking. Here, we assessed resting state functional connectivity (rsFC) at pre-treatment and during early treatment as a potential predictor of response to a novel attention bias modification procedure, gaze-contingent music reward therapy (GC-MRT). Methods Thirty-two adults with SAD were treated with GC-MRT. rsFC was assessed with multi-voxel pattern analysis of fMRI at pre-treatment and after 2-3 weeks. For comparison, 20 healthy control (HC) participants without treatment were assessed twice for rsFC over the same time period. All SAD participants underwent clinical evaluation at pre-treatment, early-treatment (week 2-3), and post-treatment. Results SAD and depressive symptoms improved significantly from pre-treatment to post-treatment. After 2-3 weeks of treatment, decreased connectivity between the executive control network (ECN) and salience network (SN), and increased connectivity within the ECN predicted improvement in SAD and depressive symptoms at week 8. Increased connectivity between the ECN and default mode network (DMN) predicted greater improvement in SAD but not depressive symptoms at week 8. Connectivity within the DMN decreased significantly after 2-3 weeks of treatment in the SAD group, while no changes were found in HC over the same time interval. Conclusion We identified early changes in rsFC during a course of GC-MRT for SAD that predicted symptom change. Connectivity changes within the ECN, ECN-DMN, and ECN-SN may be related to mechanisms underlying the clinical effects of GC-MRT and warrant further study in controlled trials. |
Shirui Wen; Huangyemin Zhang; Kailing Huang; Xiaojie Wei; Ke Yang; Quan Wang; Li Feng Impaired orienting function detected through eye movements in patients with temporal lobe epilepsy Journal Article In: Frontiers in Neuroscience, vol. 17, pp. 1–10, 2023. @article{Wen2023, Objective: Patients with temporal lobe epilepsy (TLE) often exhibit attention function impairment. The orienting network is the subsystem of the attention network that has not been fully studied. In this study, we used eye-tracking technology with an attention network test (ANT)-based task to assess the orienting function of TLE patients, aiming to characterize their eye movement patterns. Methods: A total of 37 TLE patients and 29 healthy controls (HCs) completed the ANT task based on eye-tracking technology. Orienting function damage was mainly assessed by the ANT orienting effect. Eye movement metrics, such as mean first goal-directed saccade latency (MGSL), total saccades, and saccade amplitudes, were compared between groups Results: The TLE patients had a significantly lower ANT orienting effect (HC, 54.05 ± 34.05; TLE, 32.29 ± 39.54) and lower eye-tracking orienting effect (HC, 116.98 ± 56.59; TLE, 86.72 ± 59.10) than those of the HCs. The larger orienting effects indicate that orienting responses are faster when receiving a spatial cue compared with a center cue. In the spatial cue condition, compared with HCs, the TLE group showed a longer first goal-directed saccade latency (HC, 76.77 ± 58.87ms; TLE, 115.14 ± 59.15ms), more total saccades (HC, 28.46 ± 12.30; TLE, 36.69 ± 15.13), and larger saccade amplitudes (HC, 0.75◦ ± 0.60◦; TLE, 1.36◦ ± 0.89◦). Furthermore, there was a positive correlation of the orienting-effect score between the ANT task and eye-tracking metrics (r = 0.58, p < 0.05). Conclusion: We innovatively developed a new detection method using eye-tracking technology in combination with an ANT-based task to detect the orienting function in TLE patients. The current research demonstrated that TLE patients had a significant orienting dysfunction with a specific saccade pattern characterized by a longer first goal-directed saccade latency, more total saccades, and larger saccade amplitudes. These oculomotor metrics are likely to be a better indicator of orienting function and may potentially be used for behavioral-based interventions and long-term cognition monitoring in TLE patients. |
Nikita Thomas; Jennifer H. Acton; Jonathan T. Erichsen; Tony Redmond; Matt J. Dunn Reliability of gaze-contingent perimetry Journal Article In: Behavior Research Methods, pp. 1–10, 2023. @article{Thomas2023, Standard automated perimetry, a psychophysical task performed routinely in eyecare clinics, requires observers to maintain fixation for several minutes at a time in order to measure visual field sensitivity. Detection of visual field damage is confounded by eye movements, making the technique unreliable in poorly attentive individuals and those with pathologically unstable fixation, such as nystagmus. Microperimetry, which utilizes ‘partial gaze-contingency' (PGC), aims to counteract eye movements but only corrects for gaze position errors prior to each stimulus onset. Here, we present a novel method of visual field examination in which stimulus position is updated during presentation, which we refer to as ‘continuous gaze-contingency' (CGC). In the first part of this study, we present three case examples that demonstrate the ability of CGC to measure the edges of the physiological blind spot in infantile nystagmus with greater accuracy than PGC and standard ‘no gaze-contingency' (NoGC), as initial proof-of-concept for the utility of the paradigm in measurements of absolute scotomas in these individuals. The second part of this study focused on healthy observers, in which we demonstrate that CGC has the lowest stimulus positional error (gaze-contingent precision: CGC = ± 0.29° |
Malathi Thothathiri; Jeremy Kirkwood; Abhijeet Patra; Anna Krason; Erica L. Middleton Multimodal measures of sentence comprehension in agrammatism Journal Article In: Cortex, vol. 169, pp. 309–325, 2023. @article{Thothathiri2023, Agrammatic or asyntactic comprehension is a common language impairment in aphasia. We considered three possible hypotheses about the underlying cause of this deficit, namely problems in syntactic processing, over-reliance on semantics, and a deficit in cognitive control. We tested four individuals showing asyntactic comprehension on their comprehension of syntax-semantics conflict sentences (e.g., The robber handcuffed the cop), where semantic cues pushed towards a different interpretation from syntax. Two of the four participants performed above chance on such sentences indicating that not all agrammatic individuals are impaired in structure-based interpretation. We collected additional eyetracking measures from the other two participants, who performed at chance on the conflict sentences. These measures suggested distinct underlying processing profiles in the two individuals. Cognitive assessments further suggested that one participant might have performed poorly due to a linguistic cognitive control impairment while the other had difficulty due to over-reliance on semantics. Together, the results highlight the importance of multimodal measures for teasing apart aphasic individuals' underlying deficits. They corroborate findings from neurotypical adults by showing that semantics can strongly influence comprehension and that cognitive control could be relevant for choosing between competing sentence interpretations. They extend previous findings by demonstrating variability between individuals with aphasia—cognitive control might be especially relevant for patients who are not overly reliant on semantics. Clinically, the identification of distinct underlying problems in different individuals suggests that different treatment paths might be warranted for cases who might look similar on behavioral assessments. |
Shin-ichi Tokushige; Hideyuki Matsumoto; Shun-ichi Matsuda; Satomi Inomata-Terada; Naoki Kotsuki; Masashi Hamada; Shoji Tsuji; Yoshikazu Ugawa; Yasuo Terao Early detection of cognitive decline in Alzheimer's disease using eye tracking Journal Article In: Frontiers in Aging Neuroscience, vol. 15, pp. 1–15, 2023. @article{Tokushige2023, Background: Patients with Alzheimer's disease (AD) are known to exhibit visuospatial processing impairment, as reflected in eye movements from the early stages of the disease. We investigated whether the pattern of gaze exploration during visual tasks could be useful for detecting cognitive decline at the earliest stage. Methods: Sixteen AD patients (age: 79.1 ± 7.9 years, Mini Mental State Examination [MMSE] score: 17.7 ± 5.3, mean ± standard deviation) and 16 control subjects (age: 79.4 ± 4.6, MMSE score: 26.9 ± 2.4) participated. In the visual memory task, subjects memorized presented line drawings for later recall. In the visual search tasks, they searched for a target Landolt ring of specific orientation (serial search task) or color (pop-out task) embedded among arrays of distractors. Using video-oculography, saccade parameters, patterns of gaze exploration, and pupil size change during task performance were recorded and compared between AD and control subjects. Results: In the visual memory task, the number of informative regions of interest (ROIs) fixated was significantly reduced in AD patients compared to control subjects. In the visual search task, AD patients took a significantly longer time and more saccades to detect the target in the serial but not in pop-out search. In both tasks, there was no significant difference in the saccade frequency and amplitude between groups. On-task pupil modulation during the serial search task was decreased in AD. The number of ROIs fixated in the visual memory task and search time and saccade numbers in the serial search task differentiated both grwoups of subjects with high sensitivity, whereas saccade parameters of pupil size modulation were effective in confirming normal cognition from cognitive decline with high specificity. Discussion: Reduced fixation on informative ROIs reflected impaired attentional allocation. Increased search time and saccade numbers in the visual search task indicated inefficient visual processing. Decreased on-task pupil size during visual search suggested decreased pupil modulation with cognitive load in AD patients, reflecting impaired function of the locus coeruleus. When patients perform the combination of these tasks to visualize multiple aspects of visuospatial processing, cognitive decline can be detected at an early stage with high sensitivity and specificity and its progression be evaluated. |
Tawny Tsang; Adam J. Naples; Erin C. Barney; Minhang Xie; Raphael Bernier; Geraldine Dawson; James Dziura; Susan Faja; Shafali Spurling Jeste; James C. McPartland; Charles A. Nelson; Michael Murias; Helen Seow; Catherine Sugar; Sara J. Webb; Frederick Shic; Scott P. Johnson Attention allocation during exploration of visual arrays in ASD: Results from the ABC-CT feasibility study Journal Article In: Journal of Autism and Developmental Disorders, vol. 53, no. 8, pp. 3220–3229, 2023. @article{Tsang2023, Visual exploration paradigms involving object arrays have been used to examine salience of social stimuli such as faces in ASD. Recent work suggests performance on these paradigms may associate with clinical features of ASD. We evaluate metrics from a visual exploration paradigm in 4-to-11-year-old children with ASD (n = 23; 18 males) and typical development (TD; n = 23; 13 males). Presented with arrays containing faces and nonsocial stimuli, children with ASD looked less at (p = 0.002) and showed fewer fixations to (p = 0.022) faces than TD children, and spent less time looking at each object on average (p = 0.004). Attention to the screen and faces correlated positively with social and cognitive skills in the ASD group (ps <.05). This work furthers our understanding of objective measures of visual exploration in ASD and its potential for quantifying features of ASD. |
Willem S. Boxtel; Briana N. Cox; Austin Keen; Jiyeon Lee Planning sentence production in aphasia: Evidence from structural priming and eye-tracking Journal Article In: Frontiers in Language Sciences, vol. 2, pp. 1–16, 2023. @article{Boxtel2023, Background: Grammatical encoding is impaired in many persons with aphasia (PWA), resulting in deficits in sentence production accuracies and underlying planning processes. However, relatively little is known on how these grammatical encoding deficits can be mediated in PWA. This study aimed to facilitate off-line (accuracy) and real-time (eye fixations) encoding of passive sentences through implicit structural priming, a tendency to better process a current sentence because of its grammatical similarity to a previously experienced (prime) sentence. Method: Sixteen PWA and Sixteen age-matched controls completed an eyetracking-while-speaking task, where they described a target transitive picture preceded by a comprehension prime involving either an active or passive form. We measured immediate and cumulative priming effects on proportions of passives produced for the target pictures and proportions of eye fixations made to the theme actor in the target scene before speech onset of the sentence production. Results and conclusion: Both PWA and controls produced cumulatively more passives as the experiment progressed despite an absence of immediate priming effects in PWA. Both groups also showed cumulative changes in the pre-speech eye fixations associated with passive productions, with this cumulative priming effect greater for the PWA group. These findings suggest that structural priming results in gradual adaptation of the grammatical encoding processes of PWA and that structural priming may be used as a treatment component for improving grammatical deficits in aphasia. |
Susanne M. Veen; Robert A. Perera; Laura Manning-Franke; Amma A. Agyemang; Karen Skop; Scott R. Sponheim; Elisabeth A. Wilde; Alexander Stamenkovic; James S. Thomas; William C. Walker Executive function and relation to static balance metrics in chronic mild TBI: A LIMBIC-CENC secondary analysis Journal Article In: Frontiers in Neurology, vol. 13, pp. 1–16, 2023. @article{Veen2023, Introduction: Among patients with traumatic brain injury (TBI), postural instability often persists chronically with negative consequences such as higher fall risk. One explanation may be reduced executive function (EF) required to effectively process, interpret and combine, sensory information. In other populations, a decline in higher cognitive functions are associated with a decline in walking and balance skills. Considering the link between EF decline and reduction in functional capacity, we investigated whether specific tests of executive function could predict balance function in a cohort of individuals with a history of chronic mild TBI (mTBI) and compared to individuals with a negative history of mTBI. Methods: Secondary analysis was performed on the local LIMBIC-CENC cohort (N = 338, 259 mTBI, mean 45 ± STD 10 age). Static balance was assessed with the sensory organization test (SOT). Hierarchical regression was used for each EF test outcome using the following blocks: (1) the number of TBIs sustained, age, and sex; (2) the separate Trail making test (TMT); (3) anti-saccade eye tracking items (error, latency, and accuracy); (4) Oddball distractor stimulus P300 and N200 at PZ and FZ response; and (5) Oddball target stimulus P300 and N200 at PZ and FZ response. Results: The full model with all predictors accounted for between 15.2% and 21.5% of the variability in the balance measures. The number of TBI's) showed a negative association with the SOT2 score (p = 0.002). Additionally, longer times to complete TMT part B were shown to be related to a worse SOT1 score (p = 0.038). EEG distractors had the most influence on the SOT3 score (p = 0.019). Lastly, the SOT-composite and SOT5 scores were shown to be associated with longer inhibition latencies and errors (anti-saccade latency and error |
Audrey Vialatte; Eric Chabanat; Agnès Witko; Laure Pisella In: Cognitive Neuropsychology, pp. 1–28, 2023. @article{Vialatte2023, Some dyslexics cannot process multiple letters simultaneously. It has been argued that this reduced visuo-attentional (VA) letter span could result from poor reading ability and experience. Here, moving away from reading context, we showed that dyslexic group exhibited slower visual search than normal readers group for “symbols”, defined as graphic stimuli made up of separable visual features, but not for filled objects. Slowness in symbol visual search was explained by reduced VA field and atypical ocular behaviour when processing those letter-like stimuli and was associated with reduced VA letter span and impaired elementary visuo-spatial perception. Such a basic visual search deficit can hardly be attributed to poor reading ability and experience. Moreover, because it is specific to letter-like stimuli (i.e., “symbols”), it can specifically hinder reading acquisition. Symbol visual search can easily be tested in the pre-reading phase, opening up prospects for early risk detection and prevention of VA dyslexia. |
Valldeflors Vinuela-Navarro; Joan Goset; Mikel Aldaba; Clara Mestre; Cristina Rovira-Gay; Neus Cano; Mar Ariza; Bàrbara Delàs; Maite Garolera; Meritxell Vilaseca Eye movements in patients with post-COVID condition Journal Article In: Biomedical Optics Express, vol. 14, no. 8, pp. 1–14, 2023. @article{VinuelaNavarro2023, Eye movement control is impaired in some neurological conditions, but the impact of COVID-19 on eye movements remains unknown. This study aims to investigate differences in oculomotor function and pupil response in individuals who suffer post-COVID-19 condition (PCC) with cognitive deficits. Saccades, smooth pursuit, fixation, vergence and pupillary response were recorded using an eye tracker. Eye movements and pupil response parameters were computed. Data from 16 controls, 38 COVID mild (home recovery) and 19 COVID severe (hospital admission) participants were analyzed. Saccadic latencies were shorter in controls (183 ± 54 ms) than in COVID mild (236 ± 83 ms) and COVID severe (227 ± 42 ms) participants (p = 0.017). Fixation stability was poorer in COVID mild participants (Bivariate Contour Ellipse Area of 0.80 ± 1.61° 2 vs 0.36 ± 0.65 ° 2 for controls |
Lara Koch; Norbert Kathmann; Benedikt Reuter Lack of speeded disengagement from facial expressions of disgust in remitted major depressive disorder: Evidence from an eye-movement study Journal Article In: Behaviour Research and Therapy, vol. 160, pp. 1–11, 2023. @article{Koch2023a, Acute major depression is characterized by specific abnormalities in the way emotional material is attended to. In late stages of stimulus processing, clinically depressed and dysphoric individuals show difficulties to disengage attention from emotionally negative material. It is unclear, however, whether aberrant disengagement is a transitory attentional phenomenon tied to depressive symptoms, or whether it constitutes a more stable disposition that outlast the symptomatic episode. To address this issue, the current study examined 39 currently euthymic individuals previously affected by major depression (RMD) and 40 healthy control participants reporting no lifetime psychopathology (ND). We used a gaze-contingent eye tracking paradigm designed to separately assess the attentional components of engagement and disengagement when viewing facial expressions of sadness, disgust and happiness. Never-depressed healthy participants, but not remitted euthymic individuals, showed speeded disengagement from facial expressions of disgust. We propose that the lack of this distinct acceleration in previously depressed but fully remitted individuals might reflect an attentional disposition that carries over to euthymic phases of the disease. On the other hand, a tendency to disengage quickly from areas in the visual field that convey social disdain could potentially act as a protective, possibly mood-stabilizing bias in resilient individuals. |
Josefine Waldthaler; Alexander Sperlich; Aylin König; Charlotte Stüssel; Frank Bremmer; Lars Timmermann; David Pedrosa In: NeuroImage: Clinical, vol. 37, pp. 1–11, 2023. @article{Waldthaler2023, While deep brain stimulation (DBS) in the subthalamic nucleus (STN) improves motor functions in Parkinson's disease (PD), it may also increase impulsivity by interfering with the inhibition of reflexive responses. The aim of this study was to investigate if varying the pulse frequency of STN-DBS has a modulating effect on response inhibition and its neural correlates. For this purpose, 14 persons with PD repeated an antisaccade task in three stimulation settings (DBS off, high-frequency DBS (130 Hz), mid-frequency DBS (60 Hz)) in a randomized order, while eye movements and brain activity via high-density EEG were recorded. On a behavioral level, 130 Hz DBS stimulation had no effect on response inhibition measured as antisaccade error rate, while 60 Hz DBS induced a slight but significant reduction of directional errors compared with the DBS-off state and 130 Hz DBS. Further, stimulation with both frequencies decreased the onset latency of correct antisaccades, while increasing the latency of directional errors. Time-frequency domain analysis of the EEG data revealed that 60 Hz DBS was associated with an increase in preparatory theta power over a midfrontal region of interest compared with the off-DBS state which is generally regarded as a marker of increased cognitive control. While no significant differences in brain activity over mid- and lateral prefrontal regions of interest emerged between the 60 Hz and 130 Hz conditions, both stimulation frequencies were associated with a stronger midfrontal beta desynchronization during the mental preparation for correct antisaccades compared with DBS off-state which is discussed in the context of potentially enhanced proactive recruitment of the oculomotor network. Our preliminary findings suggest that mid-frequency STN-DBS may provide beneficial effects on response inhibition, while both 130 Hz- and 60 Hz STN-DBS may promote voluntary actions at the expense of slower reflexive responses. |
Josefine Waldthaler; Lena Stock; Charlotte Krüger-Zechlin; Zain Deeb; Lars Timmermann Cluster analysis reveals distinct patterns of saccade impairment and their relation to cognitive profiles in Parkinson's disease Journal Article In: Journal of Neuropsychology, vol. 17, no. 2, pp. 251–263, 2023. @article{Waldthaler2023b, Saccade performance has been reported to be altered in Parkinson's disease (PD), however, with a large variability between studies as both motor and cognitive impairment interfere with oculomotor control. The aim of this study was to identify different patterns in saccade alterations in PD using a data-driven approach and to explore their relationship with cognitive phenotypes. Sixty-one participants with PD and 25 controls performed eye-tracking (horizontal and vertical prosaccades, antisaccades) and neuropsychological testing. Hierarchical cluster analysis was applied to the eye-tracking data to subsequently compare the clusters based on demographical, clinical and cognitive characteristics. The three identified clusters of saccade alterations differed in cognitive profiles from healthy controls, but not in PD-related motor symptoms or demographics. The rate of directive errors in the antisaccade task was increased in clusters 1 and 2. Further, cluster 1 was defined by a general disinhibition of reflexive saccades and executive dysfunction in the neuropsychological evaluation. In cluster 2, prolonged saccade latencies and hypometria were accompanied by multidomain cognitive impairment. The cluster 3 showed increased antisaccade latency and vertical hypometria despite lack of evidence for cognitive impairment. Our results suggest that there may be at least two opposing patterns of saccade alterations associated with cognitive impairment in PD, which may explain some of the contradictory results of previous studies. |
Ciara Egan; Joshua S. Payne; Manon W. Jones In: Neuropsychologia, vol. 184, pp. 1–8, 2023. @article{Egan2023, Readers with developmental dyslexia are known to be impaired in representing and accessing phonology, but their ability to process meaning is generally considered to be intact. However, neurocognitive studies show evidence of a subtle semantic processing deficit in dyslexic readers, relative to their typically-developing peers. Here, we compared dyslexic and typical adult readers on their ability to judge semantic congruency (congruent vs. inconcongruent) in short, two-word phrases, which were further manipulated for phonological relatedness (alliterating vs. non-alliterating); “dazzling-diamond”; “sparkling-diamond”; “dangerous-diamond”; and “creepy-diamond”. At the level of behavioural judgement, all readers were less accurate when evaluating incongruent alliterating items compared with incongruent non-aliterating, suggesting that phonological patterning creates the illusion of semantic congruency (as per Egan et al., 2020). Dyslexic readers showed a similar propensity for this form-meaning relationship despite a phonological processing impairment as evidenced in the cognitive and literacy indicative assessments. Dyslexic readers also showed an overall reduction in the ability to accurately judge semantic congruency, suggestive of a subtle semantic impairment. Whilst no group differences emerged in the electrophysiological measures, our pupil dilation measurements revealed a global tendency for dyslexic readers to manifest a reduced attentional response to these word stimuli, compared with typical readers. Our results show a broad manifestation of neurocognitive differences in adult dyslexic and typical readers' processing of print, at the level of autonomic arousal as well as in higher level semantic judgements. |
Ciara Egan; Anna Siyanova-Chanturia; Paul Warren; Manon W. Jones As clear as glass: How figurativeness and familiarity impact simile processing in readers with and without dyslexia Journal Article In: Quarterly Journal of Experimental Psychology, vol. 76, no. 2, pp. 231–247, 2023. @article{Egan2023a, For skilled readers, idiomatic language confers faster access to overall meaning compared with non-idiomatic language, with a processing advantage for figurative over literal interpretation. However, currently very little research exists to elucidate whether atypical readers—such as those with developmental dyslexia—show such a processing advantage for figurative interpretations of idioms, or whether their reading impairment implicates subtle differences in semantic access. We wanted to know whether an initial figurative interpretation of similes, for both typical and dyslexic readers, is dependent on familiarity. Here, we tracked typical and dyslexic readers' eye movements as they read sentences containing similes (e.g., as cold as ice), orthogonally manipulated for novelty (e.g., familiar: as cold as ice, novel: as cold as snow) and figurativeness (e.g., literal: as cold as ice [low temperature], figurative: as cold as ice [emotionally distant]), with figurativeness being defined by the sentence context. Both participant groups exhibited a processing advantage for familiar and figurative similes over novel and literal similes. However, compared with typical readers, participants with dyslexia had greater difficulty processing similes both when they were unfamiliar and when the context biased the simile meaning towards a literal rather than a figurative interpretation. Our findings suggest a semantic processing anomaly in dyslexic readers, which we discuss in light of recent literature on sentence-level semantic processing. |
Michelle L. Eisenberg; Thomas L. Rodebaugh; Shaney Flores; Jeffrey M. Zacks Impaired prediction of ongoing events in posttraumatic stress disorder Journal Article In: Neuropsychologia, vol. 188, pp. 1–12, 2023. @article{Eisenberg2023, The ability to make accurate predictions about what is going to happen in the near future is critical for comprehension of everyday activity. However, predictive processing may be disrupted in Posttraumatic Stress Disorder (PTSD). Hypervigilance may lead people with PTSD to make inaccurate predictions about the likelihood of future danger. This disruption in predictive processing may occur not only in response to threatening stimuli, but also during processing of neutral stimuli. Therefore, the current study investigated whether PTSD was associated with difficulty making predictions about near-future neutral activity. Sixty-three participants with PTSD and 63 trauma controls completed two tasks, one testing explicit prediction and the other testing implicit prediction. Higher PTSD severity was associated with greater difficulty with predictive processing on both of these tasks. These results suggest that effective treatments to improve functional outcomes for people with PTSD may work, in part, by improving predictive processing. |
Merve Ekin; Koray Koçoğlu; Hatice Eraslan Boz; Müge Akkoyun; Işıl Yağmur Tüfekci; Berna Yalınçetin; Emre Bora; Gülden Akdal Spatial working memory in prodromal stage: An eye tracking study Journal Article In: Alzheimer's & Dementia, vol. 19, pp. 1–2, 2023. @article{Ekin2023, Abstract Background: Individuals at ultra-high risk for psychosis and bipolar disorder (UHR-P and UHR-BD) have shown cognitive abnormalities and sub-threshold clinical features (de Paula et al., 2015; Metzler et al., 2014). Assessing saccadic eyemovements is one of the useful methods for investigating high cognitive functions like spatial working memory and inhibition (Pierrot-Deseilligny et al., 2005; Winograd-Gurvich et al., 2008). Memory-guided saccade (MGS)may be described as short-term maintenance of attention bothwhen a peripheral target is presented, and a delay screen. The purpose of this study was to examine the differences between clinical risk groups and healthy controls (HCs) based on the memory-guided saccade. Method: The study was included 33 UHR-P (age: 21.61 ± 3.24), 28 UHR-BD (age: 21.64 ± 4.02), and 28 HCs (age: 22.11 ± 4.03). Participants were selected from cases of clinical-high-risk criteria in interviews made with The Structured Interview of Psychosis Risk Syndromes and Bipolar Prodrome Symptom Interview and Scale. The memory-guided saccade was measured with the number of the correct, incorrect, anticipatory and express saccades, also latency, peak velocity and amplitude for the correct saccades. Eye movement data were recorded from the right eye using an EyeLink 1000 Plus eye-tracker. All results were analyzed with SPSS software. Result: The anticipatory and express saccades in the cue screen, the anticipatory saccade in the delay screen and the total error response were significant between groups (p<0.05). There was a significant increase in UHR-BD compared to controls in the error responses (p = 0.018). The anticipatory saccades in UHR-BD were higher than in both UHR-P andHCon the cue screen (p =0.005 and p=0.014), and controls on the delay screen (p = 0.027). In addition, the express saccades in the cue screen showed statistical differences between the risk groups (p = 0.032). Conclusion: Memory-guided saccades are used to assess the top-down mechanism, including perceptual organization and goal-directed behaviors, and are related to frontal lobe functions like spatial working memory and inhibitory control (Ostendorf et al., 2004). The elevation of incorrect saccades and predictive parameters like anticipatory saccades have indicated that individuals at the prodromal stage may appear spatial problems in inhibitory and exhibitory functions. |
Merve Ekin; Koray Koçoğlu; Hatice Eraslan Boz; Müge Akkoyun; Işıl Yağmur Tüfekci; Ezgi Cesim; Berna Yalınçetin; Simge Uzman Özbek; Emre Bora; Gülden Akdal Antisaccade and memory-guided saccade in individuals at ultra-high-risk for bipolar disorder Journal Article In: Journal of Affective Disorders, vol. 339, pp. 965–972, 2023. @article{Ekin2023a, Background: Ultra-high-risk for bipolar disorder (UHR-BD) is an important paradigm to investigate the potential early-stage biomarkers of bipolar disorder, including eye-tracking abnormalities and cognitive functions. Antisaccade (AS) described as looking in the opposite direction of the target, and memory-guided saccade (MGS), identified as maintaining fixation, and remembering the location of the target, were used in this study. The aim of this study was to evaluate the differences in saccadic eye movements between UHR-BD and healthy controls (HCs) via AS-MGS. Methods: The study included 28 UHR-BD and 29 HCs. Participants were selected using a structured clinical interview for prodromal symptoms of BD. AS-MGS were measured with parameters like uncorrected errors, anticipatory saccades, and latency. Eye movements were recorded with the EyeLink 1000-Plus eye-tracker. Results: In the AS, the number of correct saccades was significantly decreased in UHR-BD (p = 0.020). Anticipatory (p = 0.009) and express saccades (p = 0.040) were increased in UHR-BD. In the MGS paradigm, the correct saccades were reduced in UHR-BD (p = 0.031). In addition, anticipatory (p = 0.004) and express saccades (p = 0.012) were significantly increased in cue-screen in UHR-BD. Conclusions: To our knowledge, this is the first study to evaluate cognitive functions with eye movements in individuals at UHR-BD. The current findings showed that eye movement functions, particularly in saccadic parameters related to inhibition and spatial perception, may be affected in the UHR-BD group. Therefore, assessment of oculomotor functions may provide observation of clinical and cognitive functions in the early-stage of bipolar disorder. However, further research is needed because the potential effects of medication may affect saccadic results. |