EyeLink fMRI / MEG Publications
All EyeLink fMRI and MEG research publications (with concurrent eye tracking) up until 2023 (with some early 2024s) are listed below by year. You can search the publications using keywords such as Visual Cortex, Neural Plasticity, MEG, etc. You can also search for individual author names. If we missed any EyeLink fMRI or MEG articles, please email us!
2023 |
Hatice Eraslan Boz; Koray Koçoğlu; Müge Akkoyun; Işıl Yağmur Tüfekci; Merve Ekin; Gülden Akdal Visual search in Alzheimer's disease and amnestic mild cognitive impairment: An eye-tracking study Journal Article In: Alzheimer's & Dementia Dementia, pp. 1–10, 2023. @article{EraslanBoz2023a, INTRODUCTION: Visual search impairment is a potential cognitive marker for Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). The aim of this study is to compare eye movements during visual tracking in AD and aMCI patients versus healthy controls (HCs). METHODS: A prospective cohort study included 32 AD and 37 aMCI patients, and 33 HCs. Each participant was asked to look at the target object in a visual stimulus containing one target and eight distractors, and eye movements were recorded with EyeLink 1000 Plus. RESULTS: AD patients had fewer fixations and shorter target fixation duration than aMCI patients and HCs. Fixation durations were also shorter in aMCI patients compared to HCs. Also, AD patients were more fixated on distractors than HCs. DISCUSSION: Our findings revealed that visual search is impaired in the early stages of AD and even aMCI, highlighting the importance of addressing visual processes in the Alzheimer's continuum. Highlights: AD patients looked to distractors more and longer than the target compared to aMCI patients and older healthy individuals. aMCI patients had an impaired visual search pattern compared to healthy controls, just like patients with AD. The visual search task differentiated AD and aMCI patients from healthy individuals without dementia. |
Hatice Eraslan Boz; Koray Koçoğlu; Müge Akkoyun; Işıl Yağmur Tüfekci; Merve Ekin; Gülden Akdal In: Brain and Behavior, vol. 13, no. 11, pp. 1–11, 2023. @article{EraslanBoz2023, Background: Alzheimer's disease (AD) neuropathology affects the brain regions responsible for visuospatial skills. Accumulating evidence points to visual difficulties involving face processing in AD and amnestic mild cognitive impairment (aMCI). No study has so far examined eye movement patterns when viewing faces with neutral expressions in patients with AD. Aim: The objective of this study aimed to examine the eye movements of patients with early-stage AD, aMCI, and healthy controls (HC) during viewing face images. Materials&Methods: Thirty-one AD, 37 aMCI, and 33 HC were included in the study. Eye movements in facial stimuli were recorded with the EyeLink 1000 Plus eye-tracker. Results: Our findings showed that AD patients looked less at the eye area of interest than the nose and mouth areas of interest compared to aMCI and HC. Regardless of the group, all participants looked at the eye and nose areas of interest more and longer in the mouth area of interest. In addition, the first fixation duration to the eye area of interest of all participants was shorter than that of the nose and mouth. Discussion: Consistent with our study, studies in healthy adults revealed eye movement patterns that focused more on the eyes and nose. AD patients are unable to pay attention to the salient parts of faces, tending to focus instead on the non-informative parts. Conclusion: Our study is the first to reveal eye movement differences in face processing in AD. |
Hatice Eraslan Boz; Koray Koçoğlu; Müge Akkoyun; Işıl Yağmur Tüfekci; Merve Ekin; Pınar Özçelik; Gülden Akdal Examination of eye movements during visual scanning of real-world images in Alzheimer's disease and amnestic mild cognitive impairment Journal Article In: International Journal of Psychophysiology, vol. 190, pp. 84–93, 2023. @article{EraslanBoz2023c, Available evidence shows that Alzheimer's disease (AD) patients display inefficiencies in visual scanning of their surroundings, directing their attention towards non-relevant aspects of scenes. Not much is known about eye movements during visual scanning in individuals with amnestic mild cognitive impairment (aMCI). Notably, a consensus has yet to be reached on this issue. Furthermore, prior research has indicated the existence of visual attention deficits in individuals diagnosed with AD and aMCI. The objective of this study was to examine the visual scanning patterns of individuals diagnosed with AD, aMCI, and healthy controls (HC) when viewing various scenes. Thirty patients with AD, 32 aMCI, and 32 HC were included in the study. A set of 30 real-life scene images were presented to the participants in the visual scanning task. Participants' eye events were monitored using the EyeLink 1000 Plus in this task. The results indicate a significant reduction in total fixation duration, number of scanned areas, fixation counts, and saccade counts in AD as compared to those with aMCI and HC. The research did not reveal any significant statistical differences in eye parameters between the aMCI and HC groups. This study found abnormalities in visual scanning in AD compared to aMCI and HC. Visual scanning patterns of aMCI patients were not different from HC. Previous studies have specifically shown visual attention difficulties in AD and MCI. Our findings may be related to visual attention difficulties in AD. In addition, this study is the first to examine visual scanning behaviour with real-world images in AD and aMCI. |
Hatice Eraslan Boz; Koray Koçoğlu; Müge Akkoyun; Işıl Yağmur Tüfekci; Merve Ekin; Pınar Özçelik; Gülden Akdal In: Aging, Neuropsychology, and Cognition, pp. 1–22, 2023. @article{EraslanBoz2023b, Alzheimer's disease (AD) dementia is a degenerative illness that is characterized by a gradual decline in cognitive abilities. Amnestic mild cognitive impairment (aMCI) is seen as a precursor to AD. The changes in antisaccade performance that can be seen in MCI may provide important clues in the early detection of AD. Therefore, the antisaccade deficits in AD and aMCI remain a research question. This study aimed to examine antisaccade responses and the relationship between antisaccade and cognitive function in AD, aMCI, and healthy controls (HC). This study included 30 patients with early-stage AD, 34 with aMCI, and 32 HC. Patients with AD showed higher rates of uncorrected error, anticipatory saccades and corrected errors, as well as decreased correct saccade rates, and shortened saccade latency compared to aMCI and HC in this study. Patients with aMCI exhibited increased rates of express saccades relative to HC. The antisaccade task and cognitive domains were found to be significantly related. Our study showed that the rate of correct saccades has the capacity to distinguish AD from HC with 87% sensitivity and 86% specificity (AUC = 0.93, p < 0.001). In addition, the rate of uncorrected errors was found to be capable of distinguishing AD from HC with 84% sensitivity and 83% specificity (AUC = 0.91, p < 0.001). This study presented promising findings that these parameters can be used clinically to differentiate AD and aMCI from healthy older individuals. |
Lisa Feldmann; Carolin Zsigo; Isabelle Mörtl; Jürgen Bartling; Christian Wachinger; Frans Oort; Gerd Schulte-Körne; Ellen Greimel Emotion regulation in adolescents with major depression – Evidence from a combined EEG and eye-tracking study Journal Article In: Journal of Affective Disorders, vol. 340, pp. 899–906, 2023. @article{Feldmann2023, Background: Adolescent major depression (MD) is characterized by deficits in emotion regulation (ER). Little is known about the neurophysiological correlates that are associated with these deficits. Moreover, the additional examination of visual attention during ER would allow a more in-depth understanding of ER deficits but has not yet been applied simultaneously. Methods: N = 33 adolescents with MD and n = 35 healthy controls (HCs) aged 12–18 years performed an ER task during which they either a) down-regulated their negative affective response to negative images via cognitive reappraisal or b) attended the images without changing their affective response. During the task, the Late Positive Potential (LPP), gaze fixations on emotional image aspects, and self-reported affective responses were collected simultaneously. Results: Compared to HCs, adolescents with MD demonstrated reduced ER success based on self-report but did not differ in LPP amplitudes. Participants in both groups showed increased amplitudes in the middle LPP window when they reappraised negative pictures compared to when they attended them. Only in the HC group, increased LPP amplitudes during reappraisal were paralleled by more positive affective responses. Limitation: The applied stimuli were part of picture databases and might therefore have limited self-relevance. Conclusions: Increased LPP amplitude during ER in both groups might be specific to adolescence and might suggest that ER at this age is challenging and requires a high amount of cognitive resources. These findings provide an important starting point for future interventional studies in youth MD. |
Heather Fielding-Gebhardt; Shannon E. Kelly; Kathryn E. Unruh; Lauren M. Schmitt; Stormi L. Pulver; Pravin Khemani; Matthew W. Mosconi Sensorimotor and inhibitory control in aging FMR1 premutation carriers Journal Article In: Frontiers in Human Neuroscience, vol. 17, pp. 1–10, 2023. @article{FieldingGebhardt2023, Aging FMR1 premutation carriers are at risk of developing neurodegenerative disorders, including fragile X-associated tremor/ataxia syndrome (FXTAS), and there is a need to identify biomarkers that can aid in identification and treatment of these disorders. While FXTAS is more common in males than females, females can develop the disease, and some evidence suggests that patterns of impairment may differ across sexes. Few studies include females with symptoms of FXTAS, and as a result, little information is available on key phenotypes for tracking disease risk and progression in female premutation carriers. Our aim was to examine quantitative motor and cognitive traits in aging premutation carriers. We administered oculomotor tests of visually guided/reactive saccades (motor) and antisaccades (cognitive control) in 22 premutation carriers (73% female) and 32 age- and sex-matched healthy controls. Neither reactive saccade latency nor accuracy differed between groups. FMR1 premutation carriers showed increased antisaccade latencies relative to controls, both when considering males and females together and when analyzing females separately. Reduced saccade accuracy and increased antisaccade latency each were associated with more severe clinically rated neuromotor impairments. Findings indicate that together male and female premutation carriers show a reduced ability to rapidly exert volitional control over prepotent responses and that quantitative differences in oculomotor behavior, including control of visually guided and antisaccades, may track with FXTAS – related degeneration in male and female premutation carriers. |
Julia Fietz; Dorothee Pöhlchen; Elisabeth B. Binder; Angelika Erhardt; Susanne Lucae; Norma C. Grandi; Tamara Namendorf; Immanuel Elbau; Laura Leuchs; Leonhard Schilbach; Sanja Ilić-Ćoćić; Julius Ziebula; Iven-Alex Mücke-Heim; Yeho Kim; Julius Pape; Tanja M. Brückl; Anna-Katharine Brem; Frank Padberg; Michael Czisch; Philipp G. Sämann; Victor I. Spoormaker In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, no. 24, pp. 1–8, 2023. @article{Fietz2023, Background Neurocognitive functioning is a relevant transdiagnostic dimension in psychiatry. As pupil size dynamics track cognitive load during a working memory task, we aimed to explore if this parameter allows identification of psychophysiological subtypes in healthy participants and patients with affective and anxiety disorders. Methods Our sample consisted of 226 participants who completed the n-back task during simultaneous functional magnetic resonance imaging and pupillometry measurements. We used latent class growth modeling to identify clusters based on pupil size in response to cognitive load. In a second step, these clusters were compared on affective and anxiety symptom levels, performance in neurocognitive tests, and functional magnetic resonance imaging activity. Results The clustering analysis resulted in two distinct pupil response profiles: one with a stepwise increasing pupil size with increasing cognitive load (reactive group) and one with a constant pupil size across conditions (nonreactive group). A larger increase in pupil size was significantly associated with better performance in neurocognitive tests in executive functioning and sustained attention. Statistical maps of parametric modulation of pupil size during the n-back task showed the frontoparietal network in the positive contrast and the default mode network in the negative contrast. The pupil response profile of the reactive group was associated with more thalamic activity, likely reflecting better arousal upregulation and less deactivation of the limbic system. Conclusions Pupil measurements have the potential to serve as a highly sensitive psychophysiological readout for detection of neurocognitive deficits in the core domain of executive functioning, adding to the development of valid transdiagnostic constructs in psychiatry. |
Nathan C. Foster; Simon J. Bennett; Kiri Pullar; Joe Causer; Cristina Becchio; Daniel P. Clowes; Spencer J. Hayes Observational learning of atypical biological kinematics in autism Journal Article In: Autism Research, vol. 16, no. 9, pp. 1799–1810, 2023. @article{Foster2023, Observing and voluntarily imitating the biological kinematics displayed by a model underpins the acquisition of new motor skills via sensorimotor processes linking perception with action. Differences in voluntary imitation in autism could be related to sensorimotor processing activity during action-observation of biological motion, as well as how sensorimotor integration processing occurs across imitation attempts. Using an observational practice protocol, which minimized the active contribution of the peripheral sensorimotor system, we examined the contribution of sensorimotor processing during action-observation. The data showed that autistic participants imitated both the temporal duration and atypical kinematic profile of the observed movement with a similar level of accuracy as neurotypical participants. These findings suggest the lower-level perception-action processes responsible for encoding biological kinematics during the action-observation phase of imitation are operational in autism. As there was no task-specific engagement of the peripheral sensorimotor system during observational practice, imitation difficulties in autism are most likely underpinned by sensorimotor integration issues related to the processing of efferent and (re)afferent sensorimotor information during trial-to-trial motor execution. |
Althea Frisanco; Marco Biella; Marco Brambilla; Mariska E. Kret All that meets the eye: The contribution of reward processing and pupil mimicry on pupillary reactions to facial trustworthiness Journal Article In: Current Psychology, vol. 42, no. 14, pp. 11685–11692, 2023. @article{Frisanco2023, The present work investigates pupillary reactions induced by exposure to faces with different levels of trustworthiness. Participants' (N = 69) pupillary changes were recorded while they viewed white male faces with a neutral expression varying on facial trustworthiness. Results suggest that reward processing and pupil mimicry are relevant mechanisms driving participants' pupil reactions. However, when including both factors in one statistical model, pupil mimicry seems to be a stronger predictor than reward processing of participants' pupil dilation. Results are discussed in light of pupillometry evidence. |
Yi-Ting Jhang; Chi-Wen Liang The effect of uncertainty on attentional bias in subclinical worriers: Evidence from reaction time and eye-tracking Journal Article In: Journal of Behavior Therapy and Experimental Psychiatry, vol. 81, pp. 1–7, 2023. @article{Jhang2023, Background and objectives: High-worry individuals have been assumed to show attentional bias towards threat, particularly under high uncertainty. This study experimentally investigated the effect of uncertainty on attentional bias in subclinical worriers. Methods: A visual dot-probe task combined with eye-tracking was used to assess participants' attentional bias towards blurred and unfiltered stimuli. Fifty high-worry and 47 low-worry participants were randomly assigned to either the high- or low-uncertainty threat condition. Aversive noise bursts were delivered either unpredictably (the high-uncertainty threat condition) or predictably (the low-uncertainty threat condition) during the visual dot-probe task. Results: In the low-uncertainty threat condition, high-worry participants exhibited enhanced attentional engagement towards blurred pictures compared to low-worry participants. They also had shorter initial fixation latencies on blurred pictures than on unfiltered pictures. In the high-uncertainty threat condition, high-worry participants demonstrated more difficulty in disengaging from threatening pictures compared to low-worry participants. Limitation: First, this study used a nonclinical sample. Second, the power was limited with regard to the analysis of eye-movement data. Third, anxiety and worry induced by noise bursts were measured using subjective rating scales only. Fourth, some picture characteristics, such as luminosity and complexity, were not controlled. Finally, uncertainty related to delivery of noise bursts and pictures were both manipulated dichotomously. Conclusion: This study highlights the importance of uncertainty in the maintenance of attentional bias towards threat-related pictures in high-worry individuals. |
Brandon Keehn; Girija Kadlaskar; Rebecca McNally Keehn Elevated and accelerated: Locus coeruleus activity and visual search abilities in autistic children Journal Article In: Cortex, vol. 169, pp. 118–129, 2023. @article{Keehn2023, Background: Autistic individuals excel at visual search, however, the neural mechanism(s) underlying this advantage remain unclear. The locus coeruleus-norepinephrine (LC-NE) system, which plays a critical role in sensory perception and selective attention, has been shown to function in a persistently elevated state in individuals on the spectrum. However, the relationship between elevated tonic LC-NE activity and accelerated search in autism has not been explored. Objective: To examine the relationship between visual search abilities and resting pupil diameter (an indirect measure of tonic LC-NE activation) in autistic and neurotypical children. Methods: Participants were 24 school-aged autistic children and 24 age- and IQ-matched neurotypical children aged 8–15 years. Children completed two tasks: a resting eye-tracking task and a visual search paradigm. For the resting eye-tracking task, pupil diameter was monitored while participants fixated a central crosshair. For the visual search paradigm, participants were instructed to find the target (vertical line) embedded within an array of tilted (10°) distractor lines. The target was present on 50% of trials, and displayed within set sizes of 18, 24, and 36 items. Results: Consistent with previous studies, autistic children had significantly larger resting pupil size and searched faster and more efficiently compared to their neurotypical peers. Eye-tracking findings revealed that accelerated search was associated with fewer, not shorter, fixations in the autism group. Autistic children also showed reduced leftward search bias. Larger resting pupil size, indicative of increased tonic activation of the LC-NE system, was associated with greater search efficiency, longer fixation durations, and reduced leftward bias. Finally, within both groups reduced leftward bias was associated with increased autism symptomatology. Discussion: Together, these findings add to the existing body of research highlighting superior search in autism, suggest that elevated tonic LC-NE activity may contribute to more efficient search, and link non-social visual-spatial processing strengths to autism symptoms. |
Krista R. Kelly; Kartik Kumar; Reed M. Jost; Christina S. Cheng-Patel; Lori M. Dao; Becky Luu; David Stager; Eileen E. Birch Objective assessment of control compared with clinical triple office control score in children with intermittent exotropia Journal Article In: Journal of AAPOS, vol. 27, no. 5, pp. 291–293, 2023. @article{Kelly2023, Poor control of intermittent exotropia may be used as an indication for surgery. However, control fluctuates during the day and from day to day. The standardized triple office control score (mean of three scores on a 6-point ordinal scale) is representative of repeated assessments throughout the day, but lacks validation against an objective measure of eye movements. We report the agreement between the triple office control score measured by the referring eyecare professional and lab-measured vergence instability using an EyeLink video eye tracker. Near and distance triple office control scores were moderately correlated with vergence instability. Near, but not distance, triple office control score was moderately correlated with the percentage of time intermittent exotropia was manifest during EyeLink recording. Larger triple office control scores for intermittent exotropia provide a meaningful description of larger vergence instability, supporting its use in clinical decisions and as a measure in clinical trials.[Formula presented] |
Hyung Cho Kim; Claire M. Kaplan; Samiha Islam; Allegra S. Anderson; Megan E. Piper; Daniel E. Bradford; John J. Curtin; Kathryn A. DeYoung; Jason F. Smith; Andrew S. Fox; Alexander J. Shackman Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity Journal Article In: PLoS ONE, vol. 18, pp. 1–31, 2023. @article{Kim2023a, Tobacco smoking imposes a staggering burden on public health, underscoring the urgency of developing a deeper understanding of the processes that maintain addiction. Clinical and experience-sampling data highlight the importance of anxious withdrawal symptoms, but the underlying neurobiology has remained elusive. Mechanistic work in animals implicates the central extended amygdala (EAc)—including the central nucleus of the amygdala and the neighboring bed nucleus of the stria terminalis—but the translational relevance of these discoveries remains unexplored. Here we leveraged a randomized trial design, well-established threat-anticipation paradigm, and multidimensional battery of assessments to understand the consequences of 24-hour nicotine abstinence. The threat-anticipation paradigm had the expected consequences, amplifying subjective distress and arousal, and recruiting the canonical threat-anticipation network. Abstinence increased smoking urges and withdrawal symptoms, and potentiated threat-evoked distress, but had negligible consequences for EAc threat reactivity, raising questions about the translational relevance of prominent animal and human models of addiction. These observations provide a framework for conceptualizing nicotine abstinence and withdrawal, with implications for basic, translational, and clinical science. |
Matthew Kimble; Olivia Cappello; Kevin Fleming Hypervigilance and depression as predictors of eye tracking to ambiguous pictures in trauma survivors Journal Article In: International Journal of Psychophysiology, vol. 187, pp. 27–33, 2023. @article{Kimble2023, Hypervigilance, attentional bias, and negative views of the world play a significant role in post trauma symptomatology and can be associated with both clinical depression and posttraumatic stress. However, both theory and research suggest there may be discernible differences in attentional patterns between these two outcomes. While depression may be associated with a general negativity bias, posttraumatic stress may be specifically associated with visual scanning, hypervigilance, and threat detection. In this study, seventy-seven community trauma survivors completed self-assessments for hypervigilance, depression, and posttraumatic cognitions and then had their eyes tracked while looking at a series of thirty neutral but ambiguous and complex pictures on a computer screen. Mean age of the sample was 36.3 with 52 % of the sample identifying as female. We found that hypervigilance scores and negative views of the world predicted both the number of fixations and area of the picture covered. These factors did not predict pupil size. These findings suggest that there are discernable gaze patterns after trauma associated with posttraumatic stress but not depression. Specifically, ambiguous pictures generate more fixations and scanning that is associated with vigilance but not depression. |
Emily J. Knight; Edward G. Freedman; Evan J. Myers; Alaina S. Berruti; Leona A. Oakes; Cody Zhewei Cao; Sophie Molholm; John J. Foxe Severely attenuated visual feedback processing in children on the autism spectrum Journal Article In: Journal of Neuroscience, vol. 43, no. 13, pp. 2424–2438, 2023. @article{Knight2023, Individuals on the autism spectrum often exhibit atypicality in their sensory perception, but the neural underpinnings of these perceptual differences remain incompletely understood. One proposed mechanism is an imbalance in higher-order feedback re-entrant inputs to early sensory cortices during sensory perception, leading to increased propensity to focus on local object features over global context. We explored this theory by measuring visual evoked potentials during contour integration as considerable work has revealed that these processes are largely driven by feedback inputs from higher-order ventral visual stream regions. We tested the hypothesis that autistic individuals would have attenuated evoked responses to illusory contours compared with neurotypical controls. Electrophysiology was acquired while 29 autistic and 31 neurotypical children (7-17 years old, inclusive of both males and females) passively viewed a random series of Kanizsa figure stimuli, each consisting of four inducers that were aligned either at random rotational angles or such that contour integration would form an illusory square. Autistic children demonstrated attenuated automatic contour integration over lateral occipital regions relative to neurotypical controls. The data are discussed in terms of the role of predictive feedback processes on perception of global stimulus features and the notion that weakened “priors” may play a role in the visual processing anomalies seen in autism. |
Isabel Kreis; Lei Zhang; Matthias Mittner; Leonard Syla; Claus Lamm; Gerit Pfuhl In: Cognitive, Affective, & Behavioral Neuroscience, vol. 23, no. 3, pp. 727–741, 2023. @article{Kreis2023, Aberrant belief updating due to misestimation of uncertainty and an increased perception of the world as volatile (i.e., unstable) has been found in autism and psychotic disorders. Pupil dilation tracks events that warrant belief updating, likely reflecting the adjustment of neural gain. However, whether subclinical autistic or psychotic symptoms affect this adjustment and how they relate to learning in volatile environments remains to be unraveled. We investigated the relationship between behavioral and pupillometric markers of subjective volatility (i.e., experience of the world as unstable), autistic traits, and psychotic-like experiences in 52 neurotypical adults with a probabilistic reversal learning task. Computational modeling revealed that participants with higher psychotic-like experience scores overestimated volatility in low-volatile task periods. This was not the case for participants scoring high on autistic-like traits, who instead showed a diminished adaptation of choice-switching behavior in response to risk. Pupillometric data indicated that individuals with higher autistic- or psychotic-like trait and experience scores differentiated less between events that warrant belief updating and those that do not when volatility was high. These findings are in line with misestimation of uncertainty accounts of psychosis and autism spectrum disorders and indicate that aberrancies are already present at the subclinical level. |
Rony Lemel; Lilach Shalev; Gal Nitsan; Boaz M. Ben-David Listen up! ADHD slows spoken-word processing in adverse listening conditions: Evidence from eye movements Journal Article In: Research in Developmental Disabilities, vol. 133, pp. 1–15, 2023. @article{Lemel2023, Background: Cognitive skills such as sustained attention, inhibition and working memory are essential for speech processing, yet are often impaired in people with ADHD. Offline measures have indicated difficulties in speech recognition on multi-talker babble (MTB) background for young adults with ADHD (yaADHD). However, to-date no study has directly tested online speech processing in adverse conditions for yaADHD. Aims: Gauging the effects of ADHD on segregating the spoken target-word from its sound-sharing competitor, in MTB and working-memory (WM) load. Methods and procedures: Twenty-four yaADHD and 22 matched controls that differ in sustained attention (SA) but not in WM were asked to follow spoken instructions presented on MTB to touch a named object, while retaining one (low-load) or four (high-load) digit/s for later recall. Their eye fixations were tracked. Outcomes and results: In the high-load condition, speech processing was less accurate and slowed by 140ms for yaADHD. In the low-load condition, the processing advantage shifted from early perceptual to later cognitive stages. Fixation transitions (hesitations) were inflated for yaADHD. Conclusions and implications: ADHD slows speech processing in adverse listening conditions and increases hesitation, as speech unfolds in time. These effects, detected only by online eyetracking, relate to attentional difficulties. We suggest online speech processing as a novel purview on ADHD. What this paper adds?: We suggest speech processing in adverse listening conditions as a novel vantage point on ADHD. Successful speech recognition in noise is essential for performance across daily settings: academic, employment and social interactions. It involves several executive functions, such as inhibition and sustained attention. Impaired performance in these functions is characteristic of ADHD. However, to date there is only scant research on speech processing in ADHD. The current study is the first to investigate online speech processing as the word unfolds in time using eyetracking for young adults with ADHD (yaADHD). This method uncovered slower speech processing in multi-talker babble noise for yaADHD compared to matched controls. The performance of yaADHD indicated increased hesitation between the spoken word and sound-sharing alternatives (e.g., CANdle-CANdy). These delays and hesitations, on the single word level, could accumulate in continuous speech to significantly impair communication in ADHD, with severe implications on their quality of life and academic success. Interestingly, whereas yaADHD and controls were matched on WM standardized tests, WM load appears to affect speech processing for yaADHD more than for controls. This suggests that ADHD may lead to inefficient deployment of WM resources that may not be detected when WM is tested alone. Note that these intricate differences could not be detected using traditional offline accuracy measures, further supporting the use of eyetracking in speech tasks. Finally, communication is vital for active living and wellbeing. We suggest paying attention to speech processing in ADHD in treatment and when considering accessibility and inclusion. |
Devonte Campbell; Bernadette Ann Murphy; James Burkitt; Nicholas La Delfa; Praveen Sanmugananthan; Ushani Ambalavanar; Paul Yielder Cervico-ocular and vestibulo-ocular reflexes in subclinical neck pain and healthy individuals: A cross-sectional study Journal Article In: Brain Sciences, vol. 13, no. 11, pp. 1–15, 2023. @article{Campbell2023, Alterations in neck sensory input from recurrent neck pain (known as subclinical neck pain (SCNP)) result in disordered sensorimotor integration (SMI). The cervico-ocular (COR) and vestibulo-ocular (VOR) reflexes involve various neural substrates but are coordinated by the cerebellum and reliant upon proprioceptive feedback. Given that proprioception and cerebellar processing are impaired in SCNP, we sought to determine if COR or VOR gain is also altered. COR and VOR were assessed using an eye-tracking device in 20 SCNP (9 M and 11 F; 21.8 (SD = 2.35) years) and 17 control (7 M and 10 F; 22.40 (SD = 3.66) years) participants. COR gain (10 trials): A motorized chair rotated the trunk at a frequency of 0.04 Hz and an amplitude of 5° while participants gazed at a circular target that disappeared after three seconds. VOR gain (30 trials): Rapid bilateral head movements away from a disappearing circular target while eyes fixated on the last observed target. Independent t-tests on COR and VOR gain were performed. SCNP had a significantly larger COR gain (p = 0.006) and smaller VOR gain (p = 0.487) compared to healthy controls. The COR group differences suggest an association between proprioceptive feedback and SMI, indicating COR may be a sensitive marker of altered cerebellar processing. |
Dinis Catronas; José Sousa; Ana Rita Batista; Nathércia Lima Torres; Ana Mesquita; Vasiliki Folia; Susana Silva Duration perception for visual stimuli is impaired in dyslexia but deficits in visual processing may not be the culprits Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 1–13, 2023. @article{Catronas2023, Dyslexics underperform controls in estimating and comparing time intervals defined by visual stimuli. Accuracy in vision-based duration perception requires efficient processing of visual events because these will define the onset and offset of time intervals. Since dyslexics have difficulties processing dimensions of visual stimuli like luminance contrasts and motion, we do not know the extent to which these visual deficits are responsible for their difficulties in judging time intervals. To address this gap, we asked adults with dyslexia and matched controls to perform an interval comparison task involving five different types of visual stimuli with different levels of challenge regarding luminance contrasts and motion. If the expected disadvantage of dyslexics in visual duration perception increased for stimuli requiring increased luminance or motion processing, this would indicate that visual processing plays a role. Results showed poorer time discrimination in dyslexics, but this disadvantage did not change according to stimulus type. Complementary analyses of oculomotor behavior during the task suggested that the poorer timing performance of dyslexics may relate instead to attention and/or engagement with the task. Our findings strengthen the evidence in favor of visual duration perception deficits in dyslexia, but not the hypothesis that these result from purely visual problems. |
Melinda Y. Chang; Mark S. Borchert Comparison of eye tracking and Teller acuity cards for visual acuity assessment in pediatric cortical/cerebral visual impairment (CVI) Journal Article In: American Journal of Ophthalmology, vol. 260, pp. 115–121, 2023. @article{Chang2023, •PURPOSE: To compare eye tracking and Teller acuity cards (TAC) for assessment of visual acuity in children with cortical, or cerebral, visual impairment (CVI). •DESIGN: Reliability and validity study. • METHODS: We recruited 41 children with CVI from a single academic pediatric neuro-ophthalmology clinic. All children performed eye tracking to measure visual acuity, and 26 children completed TAC assessment by a masked examiner. Additionally, 2 pediatric neuro- ophthalmologists graded visual behavior using the 6-level Visual Behavior Scale (VBS). Eye tracking and TAC were performed at baseline and at 1 month. Test–retest reliability of eye tracking and TAC were assessed using the intraclass correlation coefficient (ICC). Eye tracking and TAC visual acuities were correlated with one another and VBS scores using the Spearman correlation coeffi- cient. • RESULTS: Test–retest reliability was excellent for eye tracking measurement of visual acuity (ICC = 0.81, P < .0001). For pediatric CVI, TAC test–retest reliability was fair (ICC = 0.42 |
Dong-Yang Chen; Qi Wang; Ning-Bo Yang; Xiao-Jing Qin; Hang Li; Wen-Peng Hou; Yu-Shen Ding; Wei-Wei Hou; Ya Wang; Fu-Chun Zhou; Chuan-Yue Wang In: Schizophrenia, vol. 9, no. 1, pp. 1–7, 2023. @article{Chen2023b, The study aimed to investigate the cognitive processing of prospective memory (PM) in patients with schizophrenia spectrum disorders (SSDs) by using an eye-tracking paradigm. In addition, the facilitating effects of prosocial intention (the desire to help others) on PM in SSDs were also examined. In phase 1, 26 patients (group1) and 25 healthy controls (HCs) were compared in an eye-tracking PM paradigm in terms of the PM accuracy and eye-tracking indices. In phase 2, 21 more patients (group2) were recruited, and a prosocial intention was introduced in the eye-tracking PM paradigm. Their PM accuracy and eye-tracking indices were compared with those in group1. The PM cue monitoring was indicated by the total fixation counts and fixation time on distractor words. In phase 1, group1 showed lower PM accuracy, fewer fixation counts and less fixation time on distractor words than HCs. In phase 2, group2 (with prosocial intention) performed significantly better than group1 (with typical instruction) on both PM accuracy and fixation time on distractor words. In both groups of SSDs, the PM accuracy was significantly correlated with both the fixation counts and the fixation time of distractor words. After controlling for the cue monitoring indices, the difference in PM accuracy remained significant between group1 and HCs but disappeared between group1 and group2. The cue monitoring deficit contributes to the PM impairment in SSDs. The facilitating effect of prosocial intention disappears after the control of cue monitoring, also indicating its critical role in PM. |
Clara Grazia Chisari; Giorgia Sciacca; Ester Reggio; Claudio Terravecchia; Francesco Patti; Mario Zappia Subclinical involvement of eye movements detected by video-based eye tracking in myasthenia gravis Journal Article In: Neurological Sciences, vol. 44, no. 7, pp. 2555–2559, 2023. @article{Chisari2023, Background: Ocular abnormalities in myasthenia gravis (MG) are characterized by severely limited movements and rapid saccades. Data about eye motility of MG patients whose ocular movements are apparently normal are lacking. Our study assessed the eye movement parameters in MG patients without clinical eye motility dysfunctions and investigated the effects of neostigmine administration on the eye motility in these patients. Materials: In this longitudinal study, we screened all patients diagnosed with MG referring to the Neurologic Clinic of the University of Catania between October 1, 2019, and June 30, 2021. Ten age- and sex-matched healthy controls were enrolled. Patients underwent eye movement recording using the EyeLink1000 Plus® eye tracker at baseline and after 90 min from the intramuscular administration of neostigmine (0.5 mg). Results: A total of 14 MG patients with no clinical signs of ocular motor dysfunction (64.3% men, with a mean age of 50.4 ± 14.4 years) were enrolled. At baseline, saccades in MG patients showed slower velocities and longer latencies compared to controls. Moreover, the fatigue test induced a reduction in saccadic velocity and an increase in latencies. After neostigmine administration, the ocular motility analysis showed shorter saccadic latencies and a significant improvement of velocities. Conclusions: Eye motility is impaired even in MG patients with no clinical evidence of ocular movement disturbance. Video-based eye tracking may detect subclinical involvement of eye movements in patients with MG. |
Laura Convertino; Daniel Bush; Fanfan Zheng; Rick A. Adams; Neil Burgess Reduced grid-like theta modulation in schizophrenia Journal Article In: Brain, vol. 146, no. 5, pp. 2191–2198, 2023. @article{Convertino2023, The hippocampal formation has been implicated in the pathophysiology of schizophrenia, with patients showing impairments in spatial and relational cognition, structural changes in entorhinal cortex and reduced theta coherence with medial prefrontal cortex. Both the entorhinal cortex and medial prefrontal cortex exhibit a 6-fold (or ‘hexadirectional') modulation of neural activity during virtual navigation that is indicative of grid cell populations and associated with accurate spatial navigation. Here, we examined whether these grid-like patterns are disrupted in schizophrenia. We asked 17 participants with diagnoses of schizophrenia and 23 controls (matched for age, sex and IQ) to perform a virtual reality spatial navigation task during magnetoencephalography. The control group showed stronger 4–10 Hz theta power during movement onset, as well as hexadirectional modulation of theta band oscillatory activity in the right entorhinal cortex whose directional stability across trials correlated with navigational accuracy. This hexadirectional modulation was absent in schizophrenia patients, with a significant difference between groups. These results suggest that impairments in spatial and relational cognition associated with schizophrenia may arise from disrupted grid firing patterns in entorhinal cortex. |
Frances G Cooley; David Quinto-pozos Supplemental material for examining speech-based phonological recoding during reading for adolescent deaf signers Journal Article In: Journal of Experimental Psychology: General, vol. 152, no. 7, pp. 1995–2007, 2023. @article{Cooley2023, Much of the debate regarding literacy development in deaf and hard-of-hearing readers surrounds whether there is dependence on phonological decoding of print to speech for such readers, and the literature is mixed. While some reports of deaf children and adults demonstrate the influence of speech-based processing during reading, others find little to no evidence of speech-sound activation. In order to examine the role of speech- based phonological codes when reading, we utilized eye-tracking to examine eye-gaze behaviors employed by deaf children and a control group of hearing primary-school children when encountering target words in sentences. The target words were of three types: correct, homophonic errors, and nonhomophonic errors.We examined eye-gaze fixations when first encountering target words and, if applicable, when rereading those words. The results revealed that deaf and hearing readers differed in their eye-movement behaviors when re- reading the words, but they did not demonstrate differences for first encounters with the words. Hearing read- ers treated homophonic and nonhomophonic error words differently during their second encounter with the target while deaf readers did not, suggesting that deaf signers did not engage in phonological decoding to the same degree as hearing readers did. Further, deaf signers performed fewer overall regressions to target words than hearing readers, suggesting that they depended less on regressions to resolve errors in the text. |
Chloe Cooper; Andrew Isaac Meso Cognitive-perceptual traits associated with autism and schizotypy influence use of physics during predictive visual tracking Journal Article In: European Journal of Neuroscience, vol. 58, no. 10, pp. 4236–4254, 2023. @article{Cooper2023, Schizophrenia and autism spectrum disorder (ASD) can disrupt cognition and consequently behaviour. Traits of ASD and the subclinical manifestation of schizophrenia called schizotypy have been studied in healthy populations with overlap found in trait profiles linking ASD social deficits to negative schizotypy and ASD attention to detail to positive schizotypy. Here, we probed the relationship between subtrait profiles, cognition and behaviour, using a predictive tracking task to measure individuals' eye movements under three gravity conditions. A total of 48 healthy participants tracked an on-screen projected ball under familiar gravity, inverted upward acceleration (against gravity) and horizontal gravity control conditions while eye movements were recorded and dynamic performance quantified. Participants completed ASD and schizotypy inventories generating highly correlated scores |
Annabell Coors; Mohammed Aslam Imtiaz; Meta M. Boenniger; N. Ahmad Aziz; Monique M. B. Breteler; Ulrich Ettinger Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes Journal Article In: Psychological Medicine, vol. 53, no. 4, pp. 1611–1619, 2023. @article{Coors2023, Background Schizophrenia is a heterogeneous disorder with substantial heritability. The use of endophenotypes may help clarify its aetiology. Measures from the smooth pursuit and antisaccade eye movement tasks have been identified as endophenotypes for schizophrenia in twin and family studies. However, the genetic basis of the overlap between schizophrenia and these oculomotor markers is largely unknown. Here, we tested whether schizophrenia polygenic risk scores (PRS) were associated with oculomotor performance in the general population. Methods Analyses were based on the data of 2956 participants (aged 30-95) of the Rhineland Study, a community-based cohort study in Bonn, Germany. Genotyping was performed on Omni-2.5 exome arrays. Using summary statistics from a recent meta-analysis based on the two largest schizophrenia genome-wide association studies to date, we quantified genetic risk for schizophrenia by creating PRS at different p value thresholds for genetic markers. We examined associations between PRS and oculomotor performance using multivariable regression models. Results Higher PRS were associated with higher antisaccade error rate and latency, and lower antisaccade amplitude gain. PRS showed inconsistent patterns of association with smooth pursuit velocity gain and were not associated with saccade rate during smooth pursuit or performance on a prosaccade control task. Conclusions There is an overlap between genetic determinants of schizophrenia and oculomotor endophenotypes. Our findings suggest that the mechanisms that underlie schizophrenia also affect oculomotor function in the general population. |
Bing Dai; Kwang Meng Cham; Larry Allen Abel Visual search in infantile nystagmus syndrome Journal Article In: Clinical and Experimental Optometry, pp. 1–8, 2023. @article{Dai2023, Clinical relevance: Research on infantile nystagmus syndrome (INS) and visual search is limited. Conducting this research could assist practitioners in understanding how INS affects the real-life visual activities of patients and aid in developing new clinical visual function assessments for INS. Background: The aim of this work is to investigate how subjects with INS perform visual search tasks, and, particularly, to assess how INS subjects perform when targets are located at their null position or away from it, and when under additional cognitive demands. Methods: INS subjects (N = 15) and controls (N = 20) performed conjunction and feature search tasks, both with and without mental arithmetic. Search performance was assessed using log-transformed total search time, gaze-dependent search time, and accuracy. Cognitive demand was quantified by pupil size and the NASA task-load index score. Results: INS subjects showed longer search times compared to controls in conjunction search (P < 0.01), but not in feature search. Within INS and control subjects, the total search times were significantly increased by the addition of mental arithmetic (P < 0.0001). There was no difference in gaze-dependent search times between null target position and 15° away from null target position of subjects in conjunction search (P > 0.05). Accuracies were 100% for both control and INS subjects in both conjunction and feature search. Conclusion: Conjunction visual search was impaired in adult INS subjects, and further worsened under increased cognitive demand. The null position did not affect the visual search performance in INS. |
Leonhard H. Drescher; C. Nico Boehler; Jan R. Wiersema A pupillometric investigation of state regulation in adults scoring high versus low on ADHD symptomatology Journal Article In: Acta Psychologica, vol. 235, pp. 1–10, 2023. @article{Drescher2023, According to the state regulation deficit (SRD) account, ADHD is associated with difficulties regulating tonic arousal levels, which may be due to inefficient effort allocation. We aimed to test the SRD account by using a target detection task with three different event rates (ER; 700 ms, 1800 ms, 6000 ms), in order to manipulate the tonic arousal state and its effects on performance and pupil indices in adults with high (n = 40) versus low (n = 36) ADHD symptom levels. In an additional condition, a fast ER (700 ms) was accompanied by auditory white noise (WN), to further increase tonic arousal level. The ER manipulation had a clear effect on RT and variability of RT. These effects were more pronounced for the high-ADHD group, especially for variability of RT with decreasing ER, suggestive of deficient upregulation of a tonic arousal state in that group, in line with their self-reported SRDs in daily life. Adding WN to the fast condition led to more errors, however similarly for both groups. Contrary to our predictions, the ER manipulation had no effect on tonic pupil size (as a measure of tonic arousal). Phasic pupil amplitude (as a measure of cognitive effort) linearly increased with decreasing ER, suggesting more effort allocation during slower ERs. WN decreased phasic pupil amplitude, but had no impact on tonic pupil size. Importantly, however, no ADHD-related differences were present for the pupil indices. In conclusion, adults with elevated levels of ADHD symptoms reported more SRDs in daily life and showed a performance pattern that suggests difficulties in upregulating but not downregulating the tonic arousal state. Surprisingly, these findings were not accompanied by group differences in pupillometric indices. This casts some doubts on the relationship between these measures of autonomic nervous system activity and state regulation, in particular in the context of ADHD symptomatology. |
Cody S. Dulaney; Jordan Murray; Fatema Ghasia Contrast sensitivity, optotype acuity and fixation eye movement abnormalities in amblyopia under binocular viewing Journal Article In: Journal of the Neurological Sciences, vol. 451, pp. 1–9, 2023. @article{Dulaney2023, Introduction: Visual function deficits are seen in amblyopic subjects during fellow and binocular viewing. The purpose of the study was to examine the relationship between Fixation Eye Movement (FEM) abnormalities and binocular contrast sensitivity and optotype acuity deficits in amblyopia. Methods: We recruited 10 controls and 25 amblyopic subjects [Anisometropic = 6 |
Kacie Dunham-Carr; Jacob I. Feldman; David M. Simon; Sarah R. Edmunds; Alexander Tu; Wayne Kuang; Julie G. Conrad; Pooja Santapuram; Mark T. Wallace; Tiffany G. Woynaroski The processing of audiovisual speech is linked with vocabulary in autistic and monautistic children: An ERP study Journal Article In: Brain Sciences, vol. 13, no. 7, pp. 1–15, 2023. @article{DunhamCarr2023, Explaining individual differences in vocabulary in autism is critical, as understanding and using words to communicate are key predictors of long-term outcomes for autistic individuals. Differences in audiovisual speech processing may explain variability in vocabulary in autism. The efficiency of audiovisual speech processing can be indexed via amplitude suppression, wherein the amplitude of the event-related potential (ERP) is reduced at the P2 component in response to audiovisual speech compared to auditory-only speech. This study used electroencephalography (EEG) to measure P2 amplitudes in response to auditory-only and audiovisual speech and norm-referenced, standardized assessments to measure vocabulary in 25 autistic and 25 nonautistic children to determine whether amplitude suppression (a) differs or (b) explains variability in vocabulary in autistic and nonautistic children. A series of regression analyses evaluated associations between amplitude suppression and vocabulary scores. Both groups demonstrated P2 amplitude suppression, on average, in response to audiovisual speech relative to auditory-only speech. Between-group differences in mean amplitude suppression were nonsignificant. Individual differences in amplitude suppression were positively associated with expressive vocabulary through receptive vocabulary, as evidenced by a significant indirect effect observed across groups. The results suggest that efficiency of audiovisual speech processing may explain variance in vocabulary in autism. |
Matt J. Dunn; Perry Carter; Jay Self; Helena Lee; Fatima Shawkat Eyetracking-enhanced VEP for nystagmus Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 1–6, 2023. @article{Dunn2023, Visual evoked potentials (VEPs) are an important prognostic indicator of visual ability in patients with nystagmus. However, VEP testing requires stable fixation, which is impossible with nystagmus. Fixation instability reduces VEP amplitude, and VEP reliability is therefore low in this important patient group. We investigated whether VEP amplitude can be increased using an eye tracker by triggering acquisition only during slow periods of the waveform. Data were collected from 10 individuals with early-onset nystagmus. VEP was obtained under continuous (standard) acquisition, or triggered during periods of low eye velocity, as detected by an eye tracker. VEP amplitude was compared using Bonferroni corrected paired samples t-tests. VEP amplitude is significantly increased when triggered during low eye velocity (95% CI 1.42–6.83 µV, t(15) = 3.25 |
Apolline Durtette; Franca Schmid; Sarah Barrière; Alexandre Obert; Julie Lang; Delphine Raucher-Chéné; Fabien Gierski; Arthur Kaladjian; Audrey Henry Facial emotion recognition processes according to schizotypal personality traits: An eye-tracking study Journal Article In: International Journal of Psychophysiology, vol. 190, pp. 60–68, 2023. @article{Durtette2023, Facial emotion recognition has been shown to be impaired among patients with schizophrenia and, to a lesser extent, among individuals with high levels of schizotypal personality traits. However, aspects of gaze behavior during facial emotion recognition among the latter are still unclear. This study therefore investigated the relations between eye movements and facial emotion recognition among nonclinical individuals with schizotypal personality traits. A total of 83 nonclinical participants completed the Schizotypal Personality Questionnaire (SPQ) and performed a facial emotion recognition task. Their gaze behavior was recorded by an eye-tracker. Self-report questionnaires measuring anxiety, depressive symptoms, and alexithymia were administered. At the behavioral level, correlation analyses showed that higher SPQ scores were associated with lower surprise recognition accuracy scores. Eye-tracking data revealed that higher SPQ scores were associated with shorter dwell time on relevant facial features during sadness recognition. Regression analyses revealed that the total SPQ score was the only significant predictor of eye movements during sadness recognition, and depressive symptoms were the only significant predictor of surprise recognition accuracy. Furthermore, dwell time predicted response times for sadness recognition in that shorter dwell time on relevant facial features was associated with longer response times. Schizotypal traits may be associated with decreased attentional engagement in relevant facial features during sadness recognition and impede participants' response times. Slower processing and altered gaze patterns during the processing of sad faces could lead to difficulties in everyday social situations in which information must be rapidly processed to enable the successful interpretation of other people's behavior. |
Anastasia Pilat; Rebecca J. McLean; Anna Vanina; Robert A. Dineen; Irene Gottlob Clinical features and imaging characteristics in achiasmia Journal Article In: Brain Communications, vol. 5, no. 4, pp. 1–11, 2023. @article{Pilat2023, Achiasmia is a rare visual pathway maldevelopment with reduced decussation of the axons in the optic chiasm. Our aim was to investigate clinical characteristics, macular, optic nerve and brain morphology in achiasmia. A prospective, cross-sectional, observational study of 12 participants with achiasmia [8 males and 4 females; 29.6 ± 18.4 years (mean ± standard deviation)] and 24 gender-, age-, ethnicity- and refraction-matched healthy controls was done. Full ophthalmology assessment, eye movement recording, a high-resolution spectral-domain optical coherence tomography of the macular and optic disc, five-channel visual-evoked responses, eye movement recordings and MRI scans of the brain and orbits were acquired. Achiasmia was confirmed in all 12 clinical participants by visual-evoked responses. Visual acuity in this group was 0.63 ± 0.19 and 0.53 ± 0.19 for the right and left eyes, respectively; most participants had mild refractive errors. All participants with achiasmia had see-saw nystagmus and no measurable stereo vision. Strabismus and abnormal head position were noted in 58% of participants. Optical coherence tomography showed optic nerve hypoplasia with associated foveal hypoplasia in four participants. In the remaining achiasmia participants, macular changes with significantly thinner paracentral inner segment (P = 0.002), wider pit (P = 0.04) and visual flattening of the ellipsoid line were found. MRI demonstrated chiasmatic aplasia in 3/12 (25%), chiasmatic hypoplasia in 7/12 (58%) and a subjectively normal chiasm in 2/12 (17%). Septo-optic dysplasia and severe bilateral optic nerve hypoplasia were found in three patients with chiasmic aplasia/hypoplasia on MRI. In this largest series of achiasmia patients to date, we found for the first time that neuronal abnormalities occur already at the retinal level. Foveal changes, optic nerve hypoplasia and the midline brain anomaly suggest that these abnormalities could be part of the same spectrum, with different manifestations of events during foetal development occurring with varying severity. |
Yair Pinto; Maria Chiara Villa; Sabrina Siliquini; Gabriele Polonara; Claudia Passamonti; Simona Lattanzi; Nicoletta Foschi; Mara Fabri; Edward H. F. Haan Visual integration across fixation: Automatic processes are split but conscious processes remain unified in the split-brain Journal Article In: Frontiers in Human Neuroscience, vol. 17, pp. 1–8, 2023. @article{Pinto2023, The classic view holds that when “split-brain” patients are presented with an object in the right visual field, they will correctly identify it verbally and with the right hand. However, when the object is presented in the left visual field, the patient verbally states that he saw nothing but nevertheless identifies it accurately with the left hand. This interaction suggests that perception, recognition and responding are separated in the two isolated hemispheres. However, there is now accumulating evidence that this interaction is not absolute; for instance, split-brain patients are able to detect and localise stimuli anywhere in the visual field verbally and with either hand. In this study we set out to explore this cross-hemifield interaction in more detail with the split-brain patient DDC and carried out two experiments. The aim of these experiments is to unveil the unity of deliberate and automatic processing in the context of visual integration across hemispheres. Experiment 1 suggests that automatic processing is split in this context. In contrast, when the patient is forced to adopt a conscious, deliberate, approach, processing seemed to be unified across visual fields (and thus across hemispheres). First, we looked at the confidence that DDC has in his responses. The experiment involved a simultaneous “same” versus “different” matching task with two shapes presented either within one hemifield or across fixation. The results showed that we replicated the observation that split brain patients cannot match across fixation, but more interesting, that DDC was very confident in the across-fixation condition while performing at chance-level. On the basis of this result, we hypothesised a two-route explanation. In healthy subjects, the visual information from the two hemifields is integrated in an automatic, unconscious fashion via the intact splenium, and this route has been severed in DDC. However, we know from previous experiments that some transfer of information remains possible. We proposed that this second route (perhaps less visual; more symbolic) may become apparent when he is forced to use a deliberate, consciously controlled approach. In an experiment where he is informed, by a second stimulus presented in one hemifield, what to do with the first stimulus that was presented in the same or the opposite hemifield, we showed that there was indeed interhemispheric transfer of information. We suggest that this two-route model may help in clarifying some of the controversial issues in split-brain research. |
Barbara L. Pitts; Michelle L. Eisenberg; Heather R. Bailey; Jeffrey M. Zacks Cueing natural event boundaries improves memory in people with post-traumatic stress disorder Journal Article In: Cognitive Research: Principles and Implications, vol. 8, no. 1, pp. 1–10, 2023. @article{Pitts2023, People with post-traumatic stress disorder (PTSD) often report difficulty remembering information in their everyday lives. Recent findings suggest that such difficulties may be due to PTSD-related deficits in parsing ongoing activity into discrete events, a process called event segmentation. Here, we investigated the causal relationship between event segmentation and memory by cueing event boundaries and evaluating its effect on subsequent memory in people with PTSD. People with PTSD (n = 38) and trauma-matched controls (n = 36) watched and remembered videos of everyday activities that were either unedited, contained visual and auditory cues at event boundaries, or contained visual and auditory cues at event middles. PTSD symptom severity varied substantial within both the group with a PTSD diagnosis and the control group. Memory performance did not differ significantly between groups, but people with high symptoms of PTSD remembered fewer details from the videos than those with lower symptoms of PTSD. Both those with PTSD and controls remembered more information from the videos in the event boundary cue condition than the middle cue or unedited conditions. This finding has important implications for translational work focusing on addressing everyday memory complaints in people with PTSD. |
Sotiris Plainis; Emmanouil Ktistakis; Miltiadis K. Tsilimbaris Presbyopia correction with multifocal contact lenses: Evaluation of silent reading performance using eye movements analysis Journal Article In: Contact Lens and Anterior Eye, vol. 46, no. 4, pp. 1–8, 2023. @article{Plainis2023, Purpose: Many activities of daily living rely on reading, thus is not surprising that complaints from presbyopes originate in reading difficulties rather in visual acuity. Here, the effectiveness of presbyopia correction with multifocal contact lenses (CLs) is evaluated using an eye-fixation based method of silent reading performance. Μethods: Visual performance of thirty presbyopic volunteers (age: 50 ± 5 yrs) was assessed monocularly and binocularly following 15 days of wear of monthly disposable CLs (AIR OPTIX™ plus HydraGlyde™, Alcon Laboratories) with: (a) single vision (SV) lenses – uncorrected for near (b) aspheric multifocal (MF) CLs. LogMAR acuity was measured with ETDRS charts. Reading performance was evaluated using standard IReST paragraphs displayed on a screen (0.4 logMAR print size at 40 cm distance). Eye movements were monitored with an infrared eyetracker (Eye-Link II, SR Research Ltd). Data analysis included computation of reading speed, fixation duration, fixations per word and percentage of regressions. Results: Average reading speed was 250 ± 68 and 235 ± 70 wpm, binocularly and monocularly, with SV CLs, improving statistically significantly to 280 ± 67 (p = 0.002) and 260 ± 59 wpm (p = 0.01), respectively, with MF CLs. Moreover, fixation duration, fixations per word and ex-Gaussian parameter of fixation duration, μ, showed a statistically significant improvement when reading with MF CLs, with fixation duration exhibiting the stronger correlation (r = 0.79, p < 0.001) with improvement in reading speed. The correlation between improvement in VA and reading speed was moderate (r = 0.46 |
Iván Plaza-Rosales; Enzo Brunetti; Rodrigo Montefusco-Siegmund; Samuel Madariaga; Rodrigo Hafelin; Daniela P. Ponce; María Isabel Behrens; Pedro E. Maldonado; Andrea Paula-Lima Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer's disease Journal Article In: Frontiers in Aging Neuroscience, vol. 15, pp. 1–14, 2023. @article{PlazaRosales2023, Introduction: Alzheimer's disease (AD) is the leading cause of dementia worldwide, but its pathophysiological phenomena are not fully elucidated. Many neurophysiological markers have been suggested to identify early cognitive impairments of AD. However, the diagnosis of this disease remains a challenge for specialists. In the present cross-sectional study, our objective was to evaluate the manifestations and mechanisms underlying visual-spatial deficits at the early stages of AD. Methods: We combined behavioral, electroencephalography (EEG), and eye movement recordings during the performance of a spatial navigation task (a virtual version of the Morris Water Maze adapted to humans). Participants (69–88 years old) with amnesic mild cognitive impairment–Clinical Dementia Rating scale (aMCI–CDR 0.5) were selected as probable early AD (eAD) by a neurologist specialized in dementia. All patients included in this study were evaluated at the CDR 0.5 stage but progressed to probable AD during clinical follow-up. An equal number of matching healthy controls (HCs) were evaluated while performing the navigation task. Data were collected at the Department of Neurology of the Clinical Hospital of the Universidad de Chile and the Department of Neuroscience of the Faculty of Universidad de Chile. Results: Participants with aMCI preceding AD (eAD) showed impaired spatial learning and their visual exploration differed from the control group. eAD group did not clearly prefer regions of interest that could guide solving the task, while controls did. The eAD group showed decreased visual occipital evoked potentials associated with eye fixations, recorded at occipital electrodes. They also showed an alteration of the spatial spread of activity to parietal and frontal regions at the end of the task. The control group presented marked occipital activity in the beta band (15–20 Hz) at early visual processing time. The eAD group showed a reduction in beta band functional connectivity in the prefrontal cortices reflecting poor planning of navigation strategies. Discussion: We found that EEG signals combined with visual-spatial navigation analysis, yielded early and specific features that may underlie the basis for understanding the loss of functional connectivity in AD. Still, our results are clinically promising for early diagnosis required to improve quality of life and decrease healthcare costs. |
Megan Polden; Trevor J. Crawford Eye movement latency coefficient of variation as a predictor of cognitive impairment: An eye tracking study of cognitive impairment Journal Article In: Vision, vol. 7, no. 2, pp. 1–12, 2023. @article{Polden2023, Studies demonstrated impairment in the control of saccadic eye movements in Alzheimer's disease (AD) and people with mild cognitive impairment (MCI) when conducting the pro-saccade and antisaccade tasks. Research showed that changes in the pro and antisaccade latencies may be particularly sensitive to dementia and general executive functioning. These tasks show potential for diagnostic use, as they provide a rich set of potential eye tracking markers. One such marker, the coefficient of variation (CV), is so far overlooked. For biological markers to be reliable, they must be able to detect abnormalities in preclinical stages. MCI is often viewed as a predecessor to AD, with certain classifications of MCI more likely than others to progress to AD. The current study examined the potential of CV scores on pro and antisaccade tasks to distinguish participants with AD, amnestic MCI (aMCI), non-amnesiac MCI (naMCI), and older controls. The analyses revealed no significant differences in CV scores across the groups using the pro or antisaccade task. Antisaccade mean latencies were able to distinguish participants with AD and the MCI subgroups. Future research is needed on CV measures and attentional fluctuations in AD and MCI individuals to fully assess this measure's potential to robustly distinguish clinical groups with high sensitivity and specificity. |
Antonella Pomè; Sandra Tyralla; Eckart Zimmermann Altered oculomotor flexibility is linked to high autistic traits Journal Article In: Scientific Reports, vol. 13, no. 1, pp. 1–12, 2023. @article{Pome2023, Autism is a multifaced disorder comprising sensory abnormalities and a general inflexibility in the motor domain. The sensorimotor system is continuously challenged to answer whether motion-contingent errors result from own movements or whether they are due to external motion. Disturbances in this decision could lead to the perception of motion when there is none and to an inflexibility with regard to motor learning. Here, we test the hypothesis that altered processing of gaze-contingent sensations are responsible for both the motor inflexibility and the sensory overload in autism. We measured motor flexibility by testing how strong participants adapted in a classical saccade adaptation task. We asked healthy participants, scored for autistic traits, to make saccades to a target that was displaced either in inward or in outward direction during saccade execution. The amount of saccade adaptation, that requires to shift the internal target representation, varied with the autistic symptom severity. The higher participants scored for autistic traits, the less they adapted. In order to test for visual stability, we asked participants to localize the position of the saccade target after they completed their saccade. We found the often-reported saccade-induced mislocalization in low Autistic Quotient (AQ) participants. However, we also found mislocalization in high AQ participants despite the absence of saccade adaptation. Our data suggest that high autistic traits are associated with an oculomotor inflexibility that might produce altered processing of trans-saccadic vision which might increase the perceptual overstimulation that is experienced in autism spectrum disorders (ASD). |
Brendan L. Portengen; Marnix Naber; Giorgio L. Porro; Douwe Bergsma; Evert J. Veldman; Saskia M. Imhof In: Eye and Brain, vol. 15, pp. 77–89, 2023. @article{Portengen2023a, Purpose: We improve pupillary responses and diagnostic performance of flicker pupil perimetry through alterations in global and local color contrast and luminance contrast in adult patients suffering from visual field defects due to cerebral visual impairment (CVI). Methods: Two experiments were conducted on patients with CVI (Experiment 1: 19 subjects, age M and SD 57.9 ± 14.0; Experiment 2: 16 subjects, age M and SD 57.3 ± 14.7) suffering from absolute homonymous visual field (VF) defects. We altered global color contrast (stimuli consisted of white, yellow, cyan and yellow-equiluminant-to-cyan colored wedges) in Experiment 1, and we manipulated luminance and local color contrast with bright and dark yellow and multicolor wedges in a 2-by-2 design in Experiment 2. Stimuli consecutively flickered across 44 stimulus locations within the inner 60 degrees of the VF and were offset to a contrasting (opponency colored) dark background. Pupil perimetry results were compared to standard automated perimetry (SAP) to assess diagnostic accuracy. Results: A bright stimulus with global color contrast using yellow (p= 0.009) or white (p= 0.006) evoked strongest pupillary responses as opposed to stimuli containing local color contrast and lower brightness. Diagnostic accuracy, however, was similar across global color contrast conditions in Experiment 1 (p= 0.27) and decreased when local color contrast and less luminance contrast was introduced in Experiment 2 (p= 0.02). The bright yellow condition resulted in highest performance (AUC M = 0.85 ± 0.10 |
Sabina Poudel; Jianzhong Jin; Hamed Rahimi-Nasrabadi; Stephen Dellostritto; Mitchell W. Dul; Suresh Viswanathan; Jose-Manuel Alonso Contrast sensitivity of ON and OFF human retinal pathways in myopia Journal Article In: The Journal of Neuroscience, vol. 44, no. 3, pp. 1–16, 2023. @article{Poudel2023, The human visual cortex processes light and dark stimuli with ON and OFF pathways that are differently modulated by luminance contrast. We have previously demonstrated that ON cortical pathways have higher contrast sensitivity than OFF cortical pathways and the difference increases with luminance range (defined as the maximum minus minimum luminance in the scene). Here, we demonstrate that these ON-OFF cortical differences are already present in the human retina and that retinal responses measured with electroretinography are more affected by reductions in luminance range than cortical responses measured with electroencephalography. Moreover, we show that ON-OFF pathway differences measured with electroretinography become more pronounced in myopia, a visual disorder that elongates the eye and blurs vision at far distance. We find that, as the eye axial length increases across subjects, ON retinal pathways become less responsive, slower in response latency, less sensitive, and less effective and slower at driving pupil constriction. Based on these results, we conclude that myopia is associated with a deficit in ON pathway function that decreases the ability of the retina to process low contrast and regulate retinal illuminance in bright environments. Significance Statement Contrast sensitivity is an important visual function that allows discriminating faint visual targets slightly lighter or darker than the background. We have previously demonstrated that ON and OFF cortical pathways signaling light and dark stimuli have different contrast sensitivity and the difference increases with luminance range. Here, we demonstrate that these ON-OFF sensitivity differences are inherited from the retina and are affected by myopia (nearsightedness), a visual disorder that blurs vision at far distances and is becoming a world epidemic. We show that myopia is associated with a retinal deficit that makes ON pathways less effective at signaling contrast and regulating retinal illuminance. These results could have clinical implications and may lead to novel approaches for myopia control. |
Sophia Antonia Press; Stefanie C. Biehl; Gregor Domes; Jennifer Svaldi; Sophia Antonia Press; Stefanie C. Biehl; Gregor Domes; Jennifer Svaldi; Sophia Antonia Press Increased insula and amygdala activity during selective attention for negatively valenced body parts in binge eating disorder Journal Article In: Journal of Psychopathology and Clinical Science, vol. 132, no. 1, pp. 63–77, 2023. @article{Press2023, Previous studies indicate that participants with eating disorders show an attentional bias for the negatively valenced body parts of their own body. However, the neural basis underlying these processes has not been investigated. We conducted a preregistered combined functional MRI (fMRI)/eye tracking study and presented 35 women with binge eating disorder (BED) and 24 weight-matched control subjects (CG) with body part images of their own body and a weight-matched unknown body. After the fMRI examination, participants rated the attractiveness of the presented body parts. As expected, women with BED responded with significantly higher insula and amygdala activity when viewing the negatively valenced body parts of their own body (compared to all other combinations). However, individuals with BED did not deviate from the CG in the processing of these stimuli in the ventromedial prefrontal cortex, the extrastriate body area or the fusiform body area. Our results indicate that the negative valued body parts carry a particularly strong emotional valence in individuals with BED. These results further emphasize the relevance of processing bias for negatively valenced body parts in the pathology of BED. |
Aida Rahavi; Manuela Malaspina; Andrea Albonico; Jason J. S. Barton “Looking at nothing”: An implicit ocular motor index of face recognition in developmental prosopagnosia Journal Article In: Cognitive Neuropsychology, vol. 40, no. 2, pp. 59–70, 2023. @article{Rahavi2023, Subjects often look towards to previous location of a stimulus related to a task even when that stimulus is no longer visible. In this study we asked whether this effect would be preserved or reduced in subjects with developmental prosopagnosia. Participants learned faces presented in video-clips and then saw a brief montage of four faces, which was replaced by a screen with empty boxes, at which time they indicated whether the learned face had been present in the montage. Control subjects were more likely to look at the blank location where the learned face had appeared, on both hit and miss trials, though the effect was larger on hit trials. Prosopagnosic subjects showed a reduced effect, though still better on hit than on miss trials. We conclude that explicit accuracy and our implicit looking at nothing effect are parallel effects reflecting the strength of the neural activity underlying face recognition. |
Isabel Raposo; Sara M. Szczepanski; Kathleen Haaland; Tor Endestad; Anne Kristin Solbakk; Robert T. Knight; Randolph F. Helfrich Periodic attention deficits after frontoparietal lesions provide causal evidence for rhythmic attentional sampling Journal Article In: Current Biology, vol. 33, no. 22, pp. 4893–4904, 2023. @article{Raposo2023, Contemporary models conceptualize spatial attention as a blinking spotlight that sequentially samples visual space. Hence, behavior fluctuates over time, even in states of presumed “sustained” attention. Recent evidence has suggested that rhythmic neural activity in the frontoparietal network constitutes the functional basis of rhythmic attentional sampling. However, causal evidence to support this notion remains absent. Using a lateralized spatial attention task, we addressed this issue in patients with focal lesions in the frontoparietal attention network. Our results revealed that frontoparietal lesions introduce periodic attention deficits, i.e., temporally specific behavioral deficits that are aligned with the underlying neural oscillations. Attention-guided perceptual sensitivity was on par with that of healthy controls during optimal phases but was attenuated during the less excitable sub-cycles. Theta-dependent sampling (3–8 Hz) was causally dependent on the prefrontal cortex, while high-alpha/low-beta sampling (8–14 Hz) emerged from parietal areas. Collectively, our findings reveal that lesion-induced high-amplitude, low-frequency brain activity is not epiphenomenal but has immediate behavioral consequences. More generally, these results provide causal evidence for the hypothesis that the functional architecture of attention is inherently rhythmic. |
Peter Reddingius; Daniel S. Asfaw; Vera M. Mönter; Nicholas D. Smith; Pete R. Jones; David P. Crabb Data on eye movements of glaucoma patients with asymmetrical visual field loss during free viewing Journal Article In: Data in Brief, vol. 48, pp. 1–7, 2023. @article{Reddingius2023, This paper describes data from Asfaw at al. [1], which examined the eye movements of glaucoma patients (n=15) with pronounced asymmetrical vision loss (visual field loss worse in one eye). This allows for within-subject comparisons between the better and worse eye, thereby controlling for the effects of individual differences between patients. All patients had a clinical diagnosis of open angle glaucoma (OAG). Participants were asked to look at images of nature monocularly (free viewing; fellow eye patched) while gaze was recorded at 1000 Hz using a remote eye tracker (EyeLink 1000). Raw and processed eye tracking data are provided. In addition, clinical (visual acuity, contrast sensitivity and visual field) and demographic information (age, sex) are provided. |
Deming Li; Ankur A. Butala; Laureano Moro-Velazquez; Trevor Meyer; Esther S. Oh; Chelsey Motley; Jesús Villalba; Najim Dehak Automating analysis of eye movement and feature extraction for different neurodegenerative disorders Journal Article In: Computers in Biology and Medicine, vol. 170, pp. 1–16, 2023. @article{Li2023b, The clinical observation and assessment of extra-ocular movements is common practice in assessing neurode- generative disorders but remains observer-dependent. In the present study, we propose an algorithm that can automatically identify saccades, fixation, smooth pursuit, and blinks using a non-invasive eye tracker. Subsequently, response-to-stimuli-derived interpretable features were elicited that objectively and quantita- tively assess patient behaviors. The cohort analysis encompasses persons with mild cognitive impairment (MCI), Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease mimics (PDM), and controls (CTRL). Overall, results suggested that the AD/MCI and PD groups had significantly different saccade and pursuit characteristics compared to CTRL when the target moved faster or covered a larger visual angle during smooth pursuit. These two groups also displayed more omitted antisaccades and longer average antisaccade latency than CTRL. When reading a text passage silently, people with AD/MCI had more fixations. During visual exploration, people with PD demonstrated a more variable saccade duration than other groups. In the prosaccade task, the PD group showed a significantly smaller average hypometria gain and accuracy, with the most statistical significance and highest AUC scores of features studied. The minimum saccade gain was a PD- specific feature different from CTRL and PDM. These features, as oculographic biomarkers, can be potentially leveraged in distinguishing different types of NDs, yielding more objective and precise protocols to diagnose and monitor disease progression. |
Haolun Li; Zhijun Li; Guanyi Lyu; Mi Wang; Bangshan Liu; Yan Zhang; Lingjiang Li; Greg J. Siegle Suicide-relevant information processing in unipolar and bipolar depression: An eye-tracking study Journal Article In: Journal of Psychopathology and Clinical Science, vol. 132, no. 4, pp. 361–371, 2023. @article{Li2023c, Suicide-relevant attentional biases are found in suicide attempters (SAs) with depression. Wenzel and Beck provide a theoretical framework that suggests suicide-related attention biases confer vulnerability to suicide. In this study, we integrated eye-tracking dynamics of suicide-related attentional biases with self-report mea- sures to test their model. A free-viewing eye-tracking paradigm, which simultaneously presented four images with different valences (suicide-related, negative, positive, neutral), was examined in 76 SAs with unipolar or bipolar depression, 66 nonsuicidal depressive participants (ND), and 105 healthy never- depressed healthy control participants (HC). Structural equation modeling (SEM) was used for the theory testing. SA gazed more at suicide-relevant stimuli throughout the 25-s trial compared with ND. SA and ND initially detected suicide-related stimuli faster than HC. Groups did not differ on how often they initially gazed at suicide images or how fast they disengaged away from them. Eye-tracking indices of attentional biases, together with self-reported hopelessness, adequately fit an SEM consistent with Wenzel and Beck's cognitive theory of suicide-related information processing. Potentially, suicide-related attention biases could increase vulnerability to suicidal ideation and eventual suicidal behaviors. |
Beatriz López; Nicola Jean Gregory; Megan Freeth Social attention patterns of autistic and non-autistic adults when viewing real versus reel people Journal Article In: Autism, vol. 27, no. 8, pp. 2372–2383, 2023. @article{Lopez2023, Research consistently shows that autistic adults do not attend to faces as much as non-autistic adults. However, this conclusion is largely based on studies using pre-recorded videos or photographs as stimuli. In studies using real social scenarios, the evidence is not as clear. To explore the extent to which differences in findings relate to differences in the methodologies used across studies, we directly compared social attention of 32 autistic and 33 non-autistic adults when watching exactly the same video. However, half of the participants in each group were told simply to watch the video (Video condition), and the other half were led to believe they were watching a live webcam feed (‘Live' condition). The results yielded no significant group differences in the ‘Live' condition. However, significant group differences were found in the ‘Video' condition. In this condition, non-autistic participants, but not autistic participants, showed a marked social bias towards faces. The findings highlight the importance of studying social attention combining different methods. Specifically, we argue that studies using pre-recorded footage and studies using real people tap into separate components contributing to social attention. One that is an innate, automatic component and one that is modulated by social norms. Lay Abstract: Early research shows that autistic adults do not attend to faces as much as non-autistic adults. However, some recent studies where autistic people are placed in scenarios with real people reveal that they attend to faces as much as non-autistic people. This study compares attention to faces in two situations. In one, autistic and non-autistic adults watched a pre-recorded video. In the other, they watched what they thought were two people in a room in the same building, via a life webcam, when in fact exactly the same video in two situations. We report the results of 32 autistic adults and 33 non-autistic adults. The results showed that autistic adults do not differ in any way from non-autistic adults when they watched what they believed was people interacting in real time. However, when they thought they were watching a video, non-autistic participants showed higher levels of attention to faces than non-autistic participants. We conclude that attention to social stimuli is the result of a combination of two processes. One innate, which seems to be different in autism, and one that is influenced by social norms, which works in the same way in autistic adults without learning disabilities. The results suggest that social attention is not as different in autism as first thought. Specifically, the study contributes to dispel long-standing deficit models regarding social attention in autism as it points to subtle differences in the use of social norms rather than impairments. |
Changlin Luo; Mengyan Zhu; Xiangling Zhuang; Guojie Ma Food word processing in Chinese reading: A study of restrained eaters Journal Article In: British Journal of Psychology, vol. 114, no. 2, pp. 476–494, 2023. @article{Luo2023a, Food-related attentional bias refers that individuals typically prioritize rewarding food-related cues (e.g. food words and food images) compared with non-food stimuli; however, the findings are inconsistent for restrained eaters. Traditional paradigms used to test food-related attentional bias, such as visual probe tasks and visual search tasks, may not directly and accurately enough to reflect individuals' food-word processing at different cognitive stages. In this study, we introduced the boundary paradigm to investigate food-word attentional bias for both restrained and unrestrained eaters. Eye movements were recorded when they performed a naturalistic sentence-reading task. The results of later-stage analyses showed that food words were fixated on for less time than non-food words, which indicated a superiority of foveal food-word processing for both restrained and unrestrained eaters. The results of early-stage analyses showed that restrained eaters spent more time on pre-target regions in the food-word valid preview conditions, which indicated a parafoveal food-word processing superiority for restrained eaters (i.e. the parafoveal-on-foveal effect). The superiority of foveal food-word processing provides new insights into explaining food-related attentional bias in general groups. Additionally, the enhanced food-word attentional bias in parafoveal processing for restrained eaters illustrates the importance of individual characteristics in studying word recognition. |
Hailong Lyu; David St Clair; Renrong Wu; Philip J. Benson; Wenbin Guo; Guodong Wang; Yi Liu; Shaohua Hu; Jingping Zhao Eye movement abnormalities can distinguish first-episode schizophrenia, chronic schizophrenia, and prodromal patients from healthy controls Journal Article In: Schizophrenia Bulletin Open, vol. 4, no. 1, pp. 1–11, 2023. @article{Lyu2023a, Background: This study attempts to replicate in a Chinese population an earlier UK report that eye movement abnormalities can accurately distinguish schizophrenia (SCZ) cases from healthy controls (HCs). It also seeks to determine whether first-episode SCZ differ from chronic SCZ and whether these eye movement abnormalities are enriched in psychosis risk syndrome (PRS). Methods: The training set included 104 Chinese HC and 60 Chinese patients with SCZ, and the testing set included 20 SCZ patients and 20 HC from a UK cohort. An additional 16 individuals with PRS were also enrolled. Eye movements of all participants were recorded during free-viewing, smooth pursuit, and fixation stability tasks. Group differences in 55 performance measures were compared and a gradient-boosted decision tree model was built for predictive analyses. Results: Extensive eye-movement abnormalities were observed in patients with SCZ on almost all eye-movement tests. On almost all individual variables, first-episode patients showed no statistically significant differences compared with chronic patients. The classification model was able to discriminate patients from controls with an area under the curve of 0.87; the model also classified 88% of PRS individuals as SCZ-like. Conclusions: Our findings replicate and extend the UK results. The overall accuracy of the Chinese study is virtually identical to the UK findings. We conclude that eye-movement abnormalities appear early in the natural history of the disorder and can be considered as potential trait markers for SCZ diathesis. |
Sylwia Macinska; Shane Lindsay; Tjeerd Jellema Visual attention to dynamic emotional faces in adults on the autism spectrum Journal Article In: Journal of Autism and Developmental Disorders, pp. 1–13, 2023. @article{Macinska2023, Using eye-tracking, we studied allocation of attention to faces where the emotional expression and eye-gaze dynamically changed in an ecologically-valid manner. We tested typically-developed (TD) adults low or high in autistic-like traits (Experiment 1), and adults with high-functioning autism (HFA; Experiment 2). All groups fixated more on the eyes than on any of the other facial area, regardless of emotion and gaze direction, though the HFA group fixated less on the eyes and more on the nose than TD controls. The sequence of dynamic facial changes affected the groups similarly, with reduced attention to the eyes and increased attention to the mouth. The results suggest that dynamic emotional face scanning patterns are stereotypical and differ only modestly between TD and HFA adults. |
Marcello Maniglia; Kristina M. Visscher; Aaron R. Seitz Consistency of preferred retinal locus across tasks and participants trained with a simulated scotoma Journal Article In: Vision Research, vol. 203, pp. 1–9, 2023. @article{Maniglia2023, After loss of central vision following retinal pathologies such as macular degeneration (MD), patients often adopt compensatory strategies including developing a “preferred retinal locus” (PRL) to replace the fovea in tasks involving fixation. A key question is whether patients develop multi-purpose PRLs or whether their oculomotor strategies adapt to the demands of the task. While most MD patients develop a PRL, clinical evidence suggests that patients may develop multiple PRLs and switch between them according to the task at hand. To understand this, we examined a model of central vision loss in normally seeing individuals and tested whether they used the same or different PRLs across tasks after training. Nineteen participants trained for 10 sessions on contrast detection while in conditions of gaze-contingent, simulated central vision loss. Before and after training, peripheral looking strategies were evaluated during tasks measuring visual acuity, reading abilities and visual search. To quantify strategies in these disparate, naturalistic tasks, we measured and compared the amount of task-relevant information at each of 8 equally spaced, peripheral locations, while participants performed the tasks. Results showed that some participants used consistent viewing strategies across tasks whereas other participants' strategies differed depending on task. This novel method allows quantification of peripheral vision use even in relatively ecological tasks. These results represent one of the first examinations of peripheral viewing strategies across tasks in simulated vision loss. Results suggest that individual differences in peripheral looking strategies following simulated central vision loss may model those developed in pathological vision loss. |
Arthur Pabst; Zoé Bollen; Nicolas Masson; Pauline Billaux; Philippe Timary; Pierre Maurage An eye-tracking study of biased attentional processing of emotional faces in severe alcohol use disorder Journal Article In: Journal of Affective Disorders, vol. 323, pp. 778–787, 2023. @article{Pabst2023, Background: Social cognition impairments in severe alcohol use disorder (SAUD) are increasingly established. However, fundamental aspects of social cognition, and notably the attentional processing of socio-affective information, remain unexplored, limiting our understanding of underlying mechanisms. Here, we determined whether patients with SAUD show attentional biases to specific socio-affective cues, namely emotional faces. Method: In a modified dot-probe paradigm, 30 patients with SAUD and 30 demographically matched healthy controls (HC) were presented with pairs of neutral-emotional (angry, disgusted, happy, sad) faces while having their eye movements recorded. Indices of early/automatic (first fixations, latency to first fixations) and later/controlled (number of fixations, dwell-time) processes were computed. Results: Patients with SAUD did not differ from HC in their attention to angry/disgusted/sad vs. neutral faces. However, patients with SAUD fixated/dwelled less on happy vs. neutral faces in the first block of stimuli than HC, who presented an attentional bias to happy faces. Limitations: Sample-size was determined to detect medium-to-large effects and subtler ones may have been missed. Further, our cross-sectional design provides no explanation as to whether the evidenced biases precede or are a consequence of SAUD. Conclusions: These results extend the social cognition literature in SAUD to the attentional domain, by evidencing the absence of a controlled attentional bias toward positive social cues in SAUD. This may reflect reduced sensitivity to social reward and could contribute to higher order social cognition difficulties and social dysfunction. |
Ashim Pandey; Sujaya Neupane; Srijana Adhikary; Keepa Vaidya; Christopher C. Pack Cortical visual impairment at birth can be improved rapidly by vision training in adulthood: A case study Journal Article In: Restorative Neurology and Neuroscience, vol. 40, no. 4-6, pp. 261–270, 2023. @article{Pandey2023, Background: Cortical visual impairment (CVI) is a severe loss of visual function caused by damage to the visual cortex or its afferents, often as a consequence of hypoxic insults during birth. It is one of the leading causes of vision loss in children, and it is most often permanent. Objective: Several studies have demonstrated limited vision restoration in adults who trained on well-controlled psychophysical tasks, after acquiring CVI late in life. Other studies have shown improvements in children who underwent vision training. However, little is known about the prospects for the large number of patients who acquired CVI at birth but received no formal therapy as children. Methods: We, therefore, conducted a proof-of-principle study in one CVI patient long after the onset of cortical damage (age 18), to test the training speed, efficacy and generalizability of vision rehabilitation using protocols that had previously proven successful in adults. The patient trained at home and in the laboratory, on a psychophysical task that required discrimination of complex motion stimuli presented in the blind field. Visual function was assessed before and after training, using perimetric measures, as well as a battery of psychophysical tests. Results: The patient showed remarkably rapid improvements on the training task, with performance going from chance to 80% correct over the span of 11 sessions. With further training, improved vision was found for untrained stimuli and for perimetric measures of visual sensitivity. Some, but not all, of these performance gains were retained upon retesting after one year. Conclusions: These results suggest that existing vision rehabilitation programs can be highly effective in adult patients who acquired CVI at a young age. Validation with a large sample size is critical, and future work should also focus on improving the usability and accessibility of these programs for younger patients. |
Ashley C. Parr; Heidi C. Riek; Brian C. Coe; Giovanna Pari; Mario Masellis; Connie Marras; Douglas P. Munoz Genetic variation in the dopamine system is associated with mixed-strategy decision-making in patients with Parkinson's disease Journal Article In: European Journal of Neuroscience, vol. 58, no. 12, pp. 4523–4544, 2023. @article{Parr2023, Decision-making during mixed-strategy games requires flexibly adapting choice strategies in response to others' actions and dynamically tracking outcomes. Such decisions involve diverse cognitive processes, including reinforcement learning, which are affected by disruptions to the striatal dopamine system. We therefore investigated how genetic variation in dopamine function affected mixed-strategy decision-making in Parkinson's disease (PD), which involves striatal dopamine pathology. Sixty-six PD patients (ages 49–85, Hoehn and Yahr Stages 1–3) and 22 healthy controls (ages 54–75) competed in a mixed-strategy game where successful performance depended on minimizing choice biases (i.e., flexibly adapting choices trial by trial). Participants also completed a fixed-strategy task that was matched for sensory input, motor outputs and overall reward rate. Factor analyses were used to disentangle cognitive from motor aspects within both tasks. Using a within-subject, multi-centre design, patients were examined on and off dopaminergic therapy, and genetic variation was examined via a multilocus genetic profile score representing the additive effects of three single nucleotide polymorphisms (SNPs) that influence dopamine transmission: rs4680 (COMT Val158Met), rs6277 (C957T) and rs907094 (encoding DARPP-32). PD and control participants displayed comparable mixed-strategy choice behaviour (overall); however, PD patients with genetic profile scores indicating higher dopamine transmission showed improved performance relative to those with low scores. Exploratory follow-up tests across individual SNPs revealed better performance in individuals with the C957T polymorphism, reflecting higher striatal D2/D3 receptor density. Importantly, genetic variation modulated cognitive aspects of performance, above and beyond motor function, suggesting that genetic variation in dopamine signalling may underlie individual differences in cognitive function in PD. |
2022 |
Lisa Kunkel genannt Bode; Anna Sophie Schulte; Björn Hauptmann; Thomas F. Münte; Andreas Sprenger; Björn Machner Gaze-contingent display technology can help to reduce the ipsilesional attention bias in hemispatial neglect following stroke Journal Article In: Journal of NeuroEngineering and Rehabilitation, vol. 19, pp. 1–15, 2022. @article{KunkelgenanntBode2022, Background: Hemispatial neglect results from unilateral brain damage and represents a disabling unawareness for objects in the hemispace opposite the brain lesion (contralesional). The patients' attentional bias for ipsilesional hemispace represents a hallmark of neglect, which results from an imbalanced attentional priority map in the brain. The aim of this study was to investigate whether gaze-contingent display (GCD) technology, reducing the visual salience of objects in ipsilesional hemispace, is able to rebalance this map and increase awareness and exploration of objects in the neglected contralesional hemispace. Methods: Using remote eye-tracking, we recorded gaze positions in 19 patients with left hemispatial neglect following right-hemisphere stroke and 22 healthy control subjects, while they were watching static naturalistic scenes. There were two task conditions, free viewing (FV) or goal-directed visual search (VS), and four modification conditions including the unmodified original picture, a purely static modification and two differently strong modifications with an additional gaze-contingent mask (GC-LOW, GC-HIGH), that continuously reduced color saturation and contrast of objects in the right hemispace. Results: The patients' median gaze position (Center of Fixation) in the original pictures was markedly deviated to the right in both tasks (FV: 6.8° ± 0.8; VS: 5.5° ± 0.7), reflecting the neglect-typical ipsilesional attention bias. GC modification significantly reduced this bias in FV (GC-HIGH: d = − 3.2 ± 0.4°; p < 0.001). Furthermore, in FV and VS, GC modification increased the likelihood to start visual exploration in the (neglected) left hemifield by about 20%. This alleviation of the ipsilesional fixation bias was not associated with an improvement in detecting left-side targets, in contrast, the GC mask even decreased and slowed the detection of right-side targets. Subjectively, patients found the intervention pleasant and most of the patients did not notice any modification. Conclusions: GCD technology can be used to positively influence visual exploration patterns in patients with hemispatial neglect. Despite an alleviation of the neglect-related ipsilesional fixation bias, a concomitant functional benefit (improved detection of contralesional targets) was not achieved. Future studies may investigate individualized GCD-based modifications as augmented reality applications during the activities of daily living. |
Haiyan Wang; Matthew Walenski; Kaitlyn Litcofsky; Jennifer E. Mack; M. Marsel Mesulam; Cynthia K. Thompson Verb production and comprehension in primary progressive aphasia Journal Article In: Journal of Neurolinguistics, vol. 64, pp. 1–18, 2022. @article{Wang2022c, Studies of word class processing have found verb retrieval impairments in individuals with primary progressive aphasia (Bak et al., 2001; Cappa et al., 1998; Cotelli et al., 2006; Hillis, Heidler-Gary, et al., 2006; Hillis, Oh, & Ken, 2004; Marcotte et al., 2014; Rhee, Antiquena, & Grossman, 2001; Silveri & Ciccarelli, 2007; Thompson, Lukic, et al., 2012) associated primarily with the agrammatic variant. However, fewer studies have focused on verb comprehension, with inconsistent results. Because verbs are critical to both production and comprehension of clauses and sentences, we investigated verb processing across domains in agrammatic, logopenic, and semantic PPA and a group of age-matched healthy controls. Participants completed a confrontation naming task for verb production and an eye-tracking word-picture matching task for online verb comprehension. All PPA groups showed impaired verb production and comprehension relative to healthy controls. Most notably, the PPA-S group performed more poorly than the other two PPA variants in both domains. Overall, the results indicate that semantic deficits in the PPA-S extend beyond object knowledge to verbs as well, adding to our knowledge concerning the nature of the language deficits in the three variants of primary progressive aphasia. |
Charlotte Moore; Elika Bergelson Examining the roles of regularity and lexical class in 18–26-month-olds' representations of how words sound Journal Article In: Journal of Memory and Language, vol. 126, pp. 1–17, 2022. @article{Moore2022a, By around 12 months, infants have well-specified phonetic representations for the nouns they understand, for instance looking less at a car upon hearing ‘cur' than ‘car' (Swingley and Aslin, 2002). Here we test whether such high-fidelity representations extend to irregular nouns, and regular and irregular verbs. A corpus analysis confirms the intuition that irregular verbs are far more common than irregular nouns in speech to young children. Two eyetracking experiments then test whether toddlers are sensitive to mispronunciation in regular and irregular nouns (Experiment 1) and verbs (Experiment 2). For nouns, we find a mispronunciation effect and no regularity effect in 18-month-olds. For verbs, in Experiment 2a, we find only a regularity effect and no mispronunciation effect in 18-month-olds, though toddlers' poor comprehension overall limits interpretation. Finally, in Experiment 2b we find a mispronunciation effect and no regularity effect in 26-month-olds. The interlocking roles of lexical class and regularity for wordform representations and early word learning are discussed. |
Mahboubeh Habibi; Wolfgang H. Oertel; Brian J. White; Donald C. Brien; Brian C. Coe; Heidi C. Riek; Julia Perkins; Rachel Yep; Laurent Itti; Lars Timmermann; Christoph Best; Elisabeth Sittig; Annette Janzen; Douglas P. Munoz Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy Journal Article In: Journal of Neurology, vol. 269, pp. 4920–4938, 2022. @article{Habibi2022, Objectives: This study (1) describes and compares saccade and pupil abnormalities in patients with manifest alpha-synucleinopathies (αSYN: Parkinson's disease (PD), Multiple System Atrophy (MSA)) and a tauopathy (progressive supranuclear palsy (PSP)); (2) determines whether patients with rapid-eye-movement sleep behaviour disorder (RBD), a prodromal stage of αSYN, already have abnormal responses that may indicate a risk for developing PD or MSA. Methods: Ninety (46 RBD, 27 PD, 17 MSA) patients with an αSYN, 10 PSP patients, and 132 healthy age-matched controls (CTRL) were examined with a 10-min video-based eye-tracking task (Free Viewing). Participants were free to look anywhere on the screen while saccade and pupil behaviours were measured. Results: PD, MSA, and PSP spent more time fixating the centre of the screen than CTRL. All patient groups made fewer macro-saccades (> 2◦ amplitude) with smaller amplitude than CTRL. Saccade frequency was greater in RBD than in other patients. Following clip change, saccades were temporarily suppressed, then rebounded at a slower pace than CTRL in all patient groups. RBD had distinct, although discrete saccade abnormalities that were more marked in PD, MSA, and even more in PSP. The vertical saccade rate was reduced in all patients and decreased most in PSP. Clip changes produced large increases or decreases in screen luminance requiring pupil constriction or dilation, respectively. PSP elicited smaller pupil constriction/dilation responses than CTRL, while MSA elicited the opposite. Conclusion: RBD patients already have discrete but less pronounced saccade abnormalities than PD and MSA patients. Vertical gaze palsy and altered pupil control differentiate PSP from αSYN. |
Christoph Helmchen; Philipp J. Koch; Gabriel Girard; Norbert Brüggemann; Björn Machner; Andreas Sprenger NPTX1-related oculomotor apraxia: An intra-hemispheric disconnection disorder Journal Article In: Journal of Neurology, vol. 269, no. 7, pp. 3931–3936, 2022. @article{Helmchen2022a, Oculomotor apraxia (OMA) is a rare and heavily disabling neurological disorder causing severe difficulties in the initia- tion and maintenance of voluntary eye movements when the head is stationary. If patients try to initiate saccades, they are grossly delayed and hypometric (stair-case). .. The aim of this study was to test competing pathophysiological hypotheses by functional and structural MRI, stating that OMA is related to either abnormal (i) inter-hemispheric or (ii) intra-hemispheric connectivity between the FEF and related oculomotor structures (oculomotor network) or (iii) both mechanisms. |
Nicola Grossheinrich; Julia Schaeffer; Christine Firk; Thomas Eggermann; Lynn Huestegge; Kerstin Konrad Childhood adversity and approach/avoidance-related behaviour in boys Journal Article In: Journal of Neural Transmission, vol. 129, pp. 421–429, 2022. @article{Grossheinrich2022, Childhood adversity has been suggested to affect the vulnerability for developmental psychopathology, including both externalizing and internalizing symptoms. This study examines spontaneous attention biases for negative and positive emotional facial expressions as potential intermediate phenotypes. In detail, typically developing boys (6–13 years) underwent an eye-tracking paradigm displaying happy, angry, sad and fearful faces. An approach bias towards positive emotional facial expressions with increasing childhood adversity levels was found. In addition, an attention bias away from negative facial expressions was observed with increasing childhood adversity levels, especially for sad facial expressions. The results might be interpreted in terms of emotional regulation strategies in boys at risk for reactive aggression and depressive behaviour. |
John M. Franchak; Kellan Kadooka Age differences in orienting to faces in dynamic scenes depend on face centering, not visual saliency Journal Article In: Infancy, vol. 27, pp. 1032–1051, 2022. @article{Franchak2022, The current study investigated how infants (6–24 months), children (2–12 years), and adults differ in how visual cues—visual saliency and centering—guide their attention to faces in videos. We report a secondary analysis of Kadooka and Franchak (2020), in which observers' eye movements were recorded during viewing of television clips containing a variety of faces. For every face on every video frame, we calculated its visual saliency (based on both static and dynamic image features) and calculated how close the face was to the center of the image. Results revealed that participants of every age looked more often at each face when it was more salient compared to less salient. In contrast, centering did not increase the likelihood that infants looked at a given face, but in later childhood and adulthood, centering became a stronger cue for face looking. A control analysis determined that the age-related change in centering was specific to face looking; participants of all ages were more likely to look at the center of the image, and this center bias did not change with age. The implications for using videos in educational and diagnostic contexts are discussed. |
Conor I. Frye; Sarah C. Creel Perceptual flexibility in word learning: Preschoolers learn words with speech sound variability Journal Article In: Brain and Language, vol. 226, pp. 1–11, 2022. @article{Frye2022, Children's language input is rife with acoustic variability. Much of this variability may facilitate learning by highlighting unvarying, criterial speech attributes. But in many cases, learners experience variation in those criterial attributes themselves, as when hearing speakers with different accents. How flexible are children in the face of this variability? The current study taught 3–5-year-olds new words containing speech-sound variability: a single picture might be labeled both deev and teev. After learning, children's knowledge was tested by presenting two pictures and asking them to point to one. Picture-pointing accuracy and eye movements were tracked. While children pointed less accurately and looked less rapidly to dual-label than single-label words, they robustly exceeded chance. Performance was weaker when children learned two distinct labels, such as vayfe and fosh, for a single object. Findings suggest moderate learning even with speech-sound variability. One implication is that neural representations of speech contain rich gradient information. |
Alma Gharib; Barbara L. Thompson Analysis and novel methods for capture of normative eye-tracking data in 2.5-month old infants Journal Article In: PloS ONE, vol. 17, pp. 1–22, 2022. @article{Gharib2022, Development of attention systems is essential for both cognitive and social behavior maturation. Visual behavior has been used to assess development of these attention systems. Yet, given its importance, there is a notable lack of literature detailing successful methods and procedures for using eye-tracking in early infancy to assess oculomotor and attention dynamics. Here we show that eye-tracking technology can be used to automatically record and assess visual behavior in infants as young as 2.5 months, and present normative data describing fixation and saccade behavior at this age. Features of oculomotor dynamics were analyzed from 2.5-month old infants who viewed videos depicting live action, cartoons, geometric shapes, social and non-social scenes. Of the 54 infants enrolled, 50 infants successfully completed the eye-tracking task and high-quality data was collected for 32 of those infants. We demonstrate that modifications specifically tailored for the infant population allowed for consistent tracking of pupil and corneal reflection and minimal data loss. Additionally, we found consistent fixation and saccade behaviors across the entire six-minute duration of the videos, indicating that this is a feasible task for 2.5-month old infants. Moreover, normative oculomotor metrics for a free-viewing task in 2.5-month old infants are documented for the first time as a result of this high-quality data collection. |
Tuomo Häikiö; Tinja Luotojärvi The effect of syllable-level hyphenation on novel word reading in early Finnish readers: Evidence from eye movements Journal Article In: Scientific Studies of Reading, vol. 26, no. 1, pp. 38–46, 2022. @article{Haeikioe2022, In early Finnish reading instruction, hyphens are used to denote syllable boundaries. However, this practice slows down reading already during the 1st grade. It has been hypothesized that hyphenation forces readers to rely more on phonology than orthography. Since hyphenation highlights the phonology of the word, it may facilitate reading during the very first encounters of the word. To assess whether this is the case, Finnish 1st and 2nd graders read stories about fictional animals while their eye movements were registered. Each story included four occurrences of a novel target (pseudo)word, hyphenated at the syllable level in half of the stories. Target words were read faster with repeated exposure but there were no effects regarding grade or hyphenation. The use of hyphenation does not give rise to enhanced processing of phonology in novel words and is likely to hinder the processes connected to the use of orthography. |
Jarkko Hautala; Ladislao Salmerón; Asko Tolvanen; Otto Loberg; Paavo Leppänen Task-oriented reading efficiency: Interplay of general cognitive ability, task demands, strategies and reading fluency Journal Article In: Reading and Writing, vol. 35, no. 8, pp. 1787–1813, 2022. @article{Hautala2022, The associations among readers' cognitive skills (general cognitive ability, reading skills, and attentional functioning), task demands (easy versus difficult questions), and process measures (total fixation time on relevant and irrelevant paragraphs) was investigated to explain task-oriented reading accuracy and efficiency (number of scores in a given time unit). Structural equation modeling was applied to a large dataset collected with sixth-grade students, which included samples of dysfluent readers and those with attention difficulties. The results are in line with previous findings regarding the dominant role of general cognitive ability in the accuracy of task-oriented reading. However, efficiency in task-oriented reading was mostly explained by the shorter viewing times of both paragraph types (i.e., relevant and irrelevant), which were modestly explained by general cognitive ability and reading fluency. These findings suggest that high efficiency in task orientation is obtained by relying on a selective reading strategy when reading both irrelevant and relevant paragraphs. The selective reading strategy seems to be specifically learned, and this potentially applies to most students, even those with low cognitive abilities. |
Andrea Helo; Ernesto Guerra; Carmen Julia Coloma; Paulina Aravena-Bravo; Pia Rämä In: Frontiers in Psychology, vol. 12, pp. 1–9, 2022. @article{Helo2022, Our visual environment is highly predictable in terms of where and in which locations objects can be found. Based on visual experience, children extract rules about visual scene configurations, allowing them to generate scene knowledge. Similarly, children extract the linguistic rules from relatively predictable linguistic contexts. It has been proposed that the capacity of extracting rules from both domains might share some underlying cognitive mechanisms. In the present study, we investigated the link between language and scene knowledge development. To do so, we assessed whether preschool children (age range = 5;4–6;6) with Developmental Language Disorder (DLD), who present several difficulties in the linguistic domain, are equally attracted to object-scene inconsistencies in a visual free-viewing task in comparison with age-matched children with Typical Language Development (TLD). All children explored visual scenes containing semantic (e.g., soap on a breakfast table), syntactic (e.g., bread on the chair back), or both inconsistencies (e.g., soap on the chair back). Since scene knowledge interacts with image properties (i.e., saliency) to guide gaze allocation during visual exploration from the early stages of development, we also included the objects' saliency rank in the analysis. The results showed that children with DLD were less attracted to semantic and syntactic inconsistencies than children with TLD. In addition, saliency modulated syntactic effect only in the group of children with TLD. Our findings indicate that children with DLD do not activate scene knowledge to guide visual attention as efficiently as children with TLD, especially at the syntactic level, suggesting a link between scene knowledge and language development. |
Andrea Helo; Ernesto Guerra; Carmen Julia Coloma; María Antonia Reyes; Pia Rämä Objects shape activation during spoken word recognition in preschoolers with typical and atypical language development: An eye-tracking study Journal Article In: Language Learning and Development, vol. 18, no. 3, pp. 324–351, 2022. @article{Helo2022a, Visually situated spoken words activate phonological, visual, and semantic representations guiding overt attention during visual exploration. We compared the activation of these representations in children with and without developmental language disorder (DLD) across four eye-tracking experiments, with a particular focus on visual (shape) representations. Two types of trials were presented in each experiment. In Experiment 1, participants heard a word while seeing (1) an object visually associated with the spoken word (i.e., shape competitor) together with a phonologically related object (i.e., cohort competitor), or (2) a shape competitor with an unrelated object. In Experiment 2 and 3, participants heard a word while seeing (1) a shape competitor with an object semantically related to the spoken word (i.e., semantic competitor), or (2) a shape competitor with an unrelated object. In Experiment 4, children heard a word while seeing a semantic competitor with (1) the visual referent of the spoken or (2) with an unrelated object. The visual context was previewed for three seconds before the spoken word, except for Experiment 2, where it appeared at the onset of the spoken word (i.e., no preview). The results showed that when a preview was provided both groups were equally attracted by cohort and semantic competitors and preferred the shape competitors over the unrelated objects. However, shape preference disappeared in the DLD group when no preview was provided and when the shape competitor was presented with a semantic competitor. Our results indicate that children with DLD have a less efficient retrieval of shape representation during word recognition compared to typically developing children. |
Holly Joseph; Daisy Powell Does a specialist typeface affect how fluently children with and without dyslexia process letters, words, and passages? Journal Article In: Dyslexia, vol. 28, no. 4, pp. 448–470, 2022. @article{Joseph2022, Children with dyslexia are at risk of poor academic attainment and lower life chances if they do not receive the support they need. Alongside phonics-based interventions which already have a strong evidence base, specialist dyslexia typefaces have been offered as an additional or alternative form of support. The current study examined whether one such typeface, Dyslexie, had a benefit over a standard typeface in identifying letters, reading words, and reading passages. 71 children, aged 8–12 years, 37 of whom had a diagnosis of dyslexia, completed a rapid letter naming task, a word reading efficiency task, and a passage reading task in two typefaces, Dyslexie and Calibri. Spacing between letters and words was kept constant. Results showed no differences in word or passage reading between the two typesfaces, but letter naming did appear to be more fluent when letters were presented in Dyslexie rather than Calibri text for all children. The results suggest that a typeface in which letters are designed to be distinctive from one another may be beneficial for letter identification and that an intervention in which children are taught letters in a specialist typeface is worthy of consideration. |
Eeva-Leena Kataja; Eeva Eskola; Juho Pelto; Riikka Korja; Sasu Petteri Paija; Saara Nolvi; Tuomo Häikiö; Linnea Karlsson; Hasse Karlsson; Jukka M. Leppänen The stability of early developing attentional bias for faces and fear from 8 to 30 and 60 months in the FinnBrain Birth Cohort Study Journal Article In: Developmental Psychology, vol. 58, no. 12, pp. 2264–2274, 2022. @article{Kataja2022, Most infants exhibit an attentional bias for faces and fearful facial expressions. These biases reduce toward the third year of life, but little is known about the development of the biases beyond early childhood. We used the same methodology longitudinally to assess attention disengagement patterns from nonface control pictures and faces (neutral, happy, and fearful expressions) in a large sample of children at 8, 30, and 60 months (N = 389/393/492, respectively; N = 72 for data in all three assessment; girls.45.3% in each assessment). “Face bias” was measured as a difference in disengagement probability (DP) from faces (neutral/happy) versus nonface patterns. “Fear bias” was calculated as a difference in DP for fearful versus happy/neutral faces. At group level, DPs followed a nonlinear longitudinal trajectory in all face conditions, being lowest at 8 months, highest at 30 months, and intermediate at 60 months. Face bias declined between 8 and 30 months, but did not change between 30 and 60 months. Fear bias declined linearly from 8 to 60 months. Individual differences in disengagement were generally not stable across age, but weak correlations were found in face bias between 8 and 60-month, and in DPs between 30 and 60-month (rs =.22–.41). The results suggest that prioritized attention to faces— that is, a hallmark of infant cognition and a key aspect of human social behavior—follows a nonlinear trajectory in early childhood and may have only weak continuity from infancy to mid childhood. |
Emmelien Merchie; Sofie Heirweg; Hilde Van Keer Mind maps: Processed as intuitively as thought? Investigating late elementary students' eye-tracked visual behavior patterns in-depth Journal Article In: Frontiers in Psychology, vol. 13, pp. 1–18, 2022. @article{Merchie2022, In this study, 44 late elementary students' visual behavior patterns when reading mind maps were investigated, more particularly, the intuitive processing nature of their visual characteristics, reading sequence and presentation mode (i.e., mind map before or after text). Eye-tracked data were investigated by means of static early attention and dynamic educational process mining (EPM) analysis and combined with learning performance and retrospective interview data. All students seem to struggle with the map's radial structure during initial reading. Also, the picture's position in the map diverts students from consecutively reading interconnected branches. EPM analyses revealed different reading patterns in proceeding reading behavior. Students receiving a text first, seem to grasp the radial structure slightly more and show higher information integration attempts. They also attained higher free recall and coherence scores. The study concludes with instructional design principles for urgently needed explicit visual literacy instruction in elementary grades. |
Sara V. Milledge; Chuanli Zang; Simon P. Liversedge; Hazel I. Blythe Phonological parafoveal pre-processing in children reading English sentences Journal Article In: Cognition, vol. 225, pp. 1–13, 2022. @article{Milledge2022a, Although previous research has shown that, in English, both adult and teenage readers parafoveally pre-process phonological information during silent reading, to date, no research has been conducted to investigate such processing in children. Here we used the boundary paradigm during silent sentence reading, to ascertain whether typically developing English children, like adults, parafoveally process words phonologically. Participants' eye movements (adults: n = 48; children: n = 48) were recorded as they read sentences which contained, in preview, correctly spelled words (e.g., cheese), pseudohomophones (e.g., cheeze), or spelling controls (e.g., cheene). The orthographic similarity of the target words available in preview was also manipulated to be similar (e.g., cheese/cheeze/cheene) or dissimilar (e.g., queen/kween/treen). The results indicate that orthographic similarity facilitated both adults' and children's pre-processing. Moreover, children parafoveally pre-processed words phonologically very early in processing. The children demonstrated a pseudohomophone advantage from preview that was broadly similar to the effect displayed by the adults, although the orthographic similarity of the pseudohomophone previews was more important for the children than the adults. Overall, these results provide strong evidence for phonological recoding during silent English sentence reading in 8–9-year-old children. |
Lyndall Murray; Signy Wegener; Hua-Chen Wang; Rauno Parrila; Anne Castles Children processing novel irregular and regular words during reading: An eye tracking study Journal Article In: Scientific Studies of Reading, vol. 26, no. 5, pp. 417–431, 2022. @article{Murray2022a, Children may link words in their oral vocabulary with novel printed word forms through a process termed mispronunciation correction, which enables them to adjust an imperfect phonological decoding. Additional evidence suggests that sentence context may play a role in helping children to make link between a word in oral vocabulary and its irregular written form. Four groups of children were orally trained on a set of novel words but received no training on a second set. Half the trained words were designated irregular spellings and half regular spellings. Children later read the words in contextually supportive or neutral sentences while their eye movements were monitored. Fixations on untrained words were longer than on trained regular words but were similar to trained irregular words. Fixations on regular words were shorter than on irregular words, and there were larger differences between irregular and regular words viewed in contextually supportive sentences. Subsequently, children were able to read irregular words more accurately when they had previously appeared in a supportive context. These results suggest that orally known irregular words undergo additional processing when first viewed in text, which is consistent with the online operation of a mispronunciation correction mechanism. |
Dinavahi V. P. S. Murty; Keerthana Manikandan; Wupadrasta Santosh Kumar; Ranjini Garani Ramesh; Simran Purokayastha; Bhargavi Nagendra; M. L. Abhishek; Aditi Balakrishnan; Mahendra Javali; Naren Prahalada Rao; Supratim Ray Stimulus-induced gamma rhythms are weaker in human elderly with mild cognitive impairment and Alzheimer's disease Journal Article In: Bio-protocol, vol. 12, no. 7, pp. 1–13, 2022. @article{Murty2022, Stimulus-induced narrow-band gamma oscillations (20–70 Hz) are induced in the visual areas of the brain when particular visual stimuli, such as bars, gratings, or full-screen hue, are shown to the subject. Such oscillations are modulated by higher cognitive functions, like attention, and working memory, and have been shown to be abnormal in certain neuropsychiatric disorders, such as schizophrenia, autism, and Alzheimer's disease. However, although electroencephalogram (EEG) remains one of the most non-invasive, inexpensive, and accessible methods to record brain signals, some studies have failed to observe discernable gamma oscillations in human EEG. In this manuscript, we have described in detail a protocol to elicit robust gamma oscillations in human EEG. We believe that our protocol could help in developing non-invasive gamma-based biomarkers in human EEG, for the early detection of neuropsychiatric disorders. |
Victoria I. Nicholls; Jan M. Wiener; Andrew Isaac Meso; Sebastien Miellet The relative contribution of executive functions and aging on attentional control during road crossing Journal Article In: Frontiers in Psychology, vol. 13, pp. 1–9, 2022. @article{Nicholls2022, As we age, many physical, perceptual and cognitive abilities decline, which can critically impact our day-to-day lives. However, the decline of many abilities is concurrent; thus, it is challenging to disentangle the relative contributions of different abilities in the performance deterioration in realistic tasks, such as road crossing, with age. Research into road crossing has shown that aging and a decline in executive functioning (EFs) is associated with altered information sampling and less safe crossing decisions compared to younger adults. However, in these studies declines in age and EFs were confounded. Therefore, it is impossible to disentangle whether age-related declines in EFs impact on visual sampling and road-crossing performance, or whether visual exploration, and road-crossing performance, are impacted by aging independently of a decline in EFs. In this study, we recruited older adults with maintained EFs to isolate the impacts of aging independently of a decline EFs on road crossing abilities. We recorded eye movements of younger adults and older adults while they watched videos of road traffic and were asked to decide when they could cross the road. Overall, our results show that older adults with maintained EFs sample visual information and make similar road crossing decisions to younger adults. Our findings also reveal that both environmental constraints and EF abilities interact with aging to influence how the road-crossing task is performed. Our findings suggest that older pedestrians' safety, and independence in day-to-day life, can be improved through a limitation of scene complexity and a preservation of EF abilities. |
Gal Nitsan; Shai Baharav; Dalith Tal-Shir; Vered Shakuf; Boaz M. Ben-David In: JMIR Serious Games, vol. 10, no. 3, pp. 1–15, 2022. @article{Nitsan2022, Background: The number of serious games for cognitive training in aging (SGCTAs) is proliferating in the market and attempting to combat one of the most feared aspects of aging-cognitive decline. However, the efficacy of many SGCTAs is still questionable. Even the measures used to validate SGCTAs are up for debate, with most studies using cognitive measures that gauge improvement in trained tasks, also known as near transfer. This study takes a different approach, testing the efficacy of the SGCTA-Effectivate-in generating tangible far-transfer improvements in a nontrained task-the Eye tracking of Word Identification in Noise Under Memory Increased Load (E-WINDMIL)-which tests speech processing in adverse conditions. Objective: This study aimed to validate the use of a real-time measure of speech processing as a gauge of the far-transfer efficacy of an SGCTA designed to train executive functions. Methods: In a randomized controlled trial that included 40 participants, we tested 20 (50%) older adults before and after self-administering the SGCTA Effectivate training and compared their performance with that of the control group of 20 (50%) older adults. The E-WINDMIL eye-tracking task was administered to all participants by blinded experimenters in 2 sessions separated by 2 to 8 weeks. Results: Specifically, we tested the change between sessions in the efficiency of segregating the spoken target word from its sound-sharing alternative, as the word unfolds in time. We found that training with the SGCTA Effectivate improved both early and late speech processing in adverse conditions, with higher discrimination scores in the training group than in the control group (early processing: F1 |
Gal Nitsan; Karen Banai; Boaz M. Ben-David One size does not fit all: Examining the effects of working memory capacity on spoken word recognition in older adults using eye tracking Journal Article In: Frontiers in Psychology, vol. 13, pp. 1–12, 2022. @article{Nitsan2022a, Difficulties understanding speech form one of the most prevalent complaints among older adults. Successful speech perception depends on top-down linguistic and cognitive processes that interact with the bottom-up sensory processing of the incoming acoustic information. The relative roles of these processes in age-related difficulties in speech perception, especially when listening conditions are not ideal, are still unclear. In the current study, we asked whether older adults with a larger working memory capacity process speech more efficiently than peers with lower capacity when speech is presented in noise, with another task performed in tandem. Using the Eye-tracking of Word Identification in Noise Under Memory Increased Load (E-WINDMIL) an adapted version of the “visual world” paradigm, 36 older listeners were asked to follow spoken instructions presented in background noise, while retaining digits for later recall under low (single-digit) or high (four-digits) memory load. In critical trials, instructions (e.g., “point at the candle”) directed listeners' gaze to pictures of objects whose names shared onset or offset sounds with the name of a competitor that was displayed on the screen at the same time (e.g., candy or sandal). We compared listeners with different memory capacities on the time course for spoken word recognition under the two memory loads by testing eye-fixations on a named object, relative to fixations on an object whose name shared phonology with the named object. Results indicated two trends. (1) For older adults with lower working memory capacity, increased memory load did not affect online speech processing, however, it impaired offline word recognition accuracy. (2) The reverse pattern was observed for older adults with higher working memory capacity: increased task difficulty significantly decreases online speech processing efficiency but had no effect on offline word recognition accuracy. Results suggest that in older adults, adaptation to adverse listening conditions is at least partially supported by cognitive reserve. Therefore, additional cognitive capacity may lead to greater resilience of older listeners to adverse listening conditions. The differential effects documented by eye movements and accuracy highlight the importance of using both online and offline measures of speech processing to explore age-related changes in speech perception. |
Sara S. Nozadi; Andrea Aguiar; Ruofei Du; Elizabeth A. Enright; Susan L. Schantz; Curtis Miller; Brandon Rennie; Mallery Quetawki; Debra MacKenzie; Johnnye L. Lewis Cross-cultural applicability of eye-tracking in assessing attention to emotional faces in preschool-aged children Journal Article In: Emotion, vol. 23, no. 5, pp. 1385–1399, 2022. @article{Nozadi2022, Humans show an attention bias toward emotional versus neutral information, which is considered an adaptive pattern of information processing. Deviations from this pattern have been observed in children with socially withdrawn behaviors, with most research being conducted in controlled settings among children from urban areas. The goal of the current study was to examine the crosscultural applicability of two eye-tracking–based measures in assessing attention biases and their relations to children's symptoms of socially withdrawn behaviors in two independent and diverse samples of preschool children. The cross-cultural comparison was conducted between the Navajo Birth Cohort study (NBCS), an indigenous cohort with relatively low socioeconomic status (SES), and the Illinois Kids Development study (IKIDS), a primarily Non-Hispanic White and high SES cohort. Children in both cohorts completed eye-tracking tasks with pictures of emotional faces, and mothers reported on children's symptoms of socially withdrawn behaviors. Results showed that general patterns of attention biases were mostly the same across samples, reflecting heightened attention toward emotional versus neutral faces. The differences across two samples mostly involved the magnitude of attention biases. NBCS children were slower to disengage from happy faces when these emotional faces were paired with neutral faces. Additionally, socially withdrawn children in the NBCS sample showed a pattern of attentional avoidance for emotional faces. The comparability of overall patterns of attention biases provides initial support for the cross-cultural applicability of the eye-tracking measures and demonstrates the robustness of these methods across clinical and community settings. |
Marissa Ogren; Scott P. Johnson Nonverbal emotion perception and vocabulary in late infancy Journal Article In: Infant Behavior and Development, vol. 68, pp. 1–10, 2022. @article{Ogren2022, Language has been proposed as a potential mechanism for young children's developing understanding of emotion. However, much remains unknown about this relation at an individual difference level. The present study investigated 15- to 18-month-old infants' perception of emotions across multiple pairs of faces. Parents reported their child's productive vocabulary, and infants participated in a non-linguistic emotion perception task via an eye tracker. Infant vocabulary did not predict nonverbal emotion perception when accounting for infant age, gender, and general object perception ability (β = −0.15 |
Anna-Katariina Aatsinki; Eeva-Leena Kataja; Eveliina Munukka; Leo Lahti; Anniina Keskitalo; Riikka Korja; Saara Nolvi; Tuomo Häikiö; Saija Tarro; Hasse Karlsson; Linnea Karlsson Infant fecal microbiota composition and attention to emotional faces Journal Article In: Emotion, vol. 22, no. 6, pp. 1159–1170, 2022. @article{Aatsinki2022, The gut microbiota has been suggested to influence neurodevelopment in rodents. Preliminary human studies have associated fecal microbiota composition with features of emotional and cognitive development as well as differences in thalamus-amygdala connectivity. Currently, microbiota-gut-brain axis studies cover heterogenous set of infant and child brain developmental phenotypes, while microbiota associations with more fine-grained aspects of brain development remain largely unknown. Here (N = 122, 53% boys), we investigated the associations between infant fecal microbiota composition and infant attention to emotional faces, as bias for faces is strong in infancy and deviations in early processing of emotional facial expressions may influence the trajectories of social-emotional development. The fecal microbiota composition was assessed at 2.5 months of age and analyzed with 16S rRNA gene sequencing. Attention to emotional faces was assessed with an age-appropriate face-distractor paradigm, using neutral, happy, fearful, and scrambled faces and salient distractors, at 8 months of age. We observed an association between a lower abundance of Bifidobacterium and a higher abundance of Clostridium with an increased “fear bias,” that is, attention toward fearful versus happy/neutral faces. This data suggests an association between early microbiota and later fear bias, a well-established infant phenotype of emotionally directed attention. However, the clinical significance or causality of our findings remains to be assessed. |
Evin Aktar; Cosima A. Nimphy; Mariska E. Kret; Koraly Pérez-Edgar; Maartje E. J. Raijmakers; Susan M. Bögels Attention biases to threat in infants and parents: Links to parental and infant anxiety dispositions Journal Article In: Research on Child and Adolescent Psychopathology, vol. 50, no. 3, pp. 387–402, 2022. @article{Aktar2022, Parent-to-child transmission of information processing biases to threat is a potential causal mechanism in the family aggregation of anxiety symptoms and traits. This study is the first to investigate the link between infants' and parents' attention bias to dynamic threat-relevant (versus happy) emotional expressions. Moreover, the associations between infant attention and anxiety dispositions in infants and parents were explored. Using a cross-sectional design, we tested 211 infants in three age groups: 5-to-7-month-olds (n = 71), 11-to-13-month-olds (n = 73), and 17-to-19-month-olds (n = 67), and 216 parents (153 mothers). Infant and parental dwell times to angry and fearful versus happy facial expressions were measured via eye-tracking. The parents also reported on their anxiety and stress. Ratings of infant temperamental fear and distress were averaged across both parents. Parents and infants tended to show an attention bias for fearful faces with marginally longer dwell times to fearful versus happy faces. Parents dwelled longer on angry versus happy faces, whereas infants showed an avoidant pattern with longer dwell times to happy versus angry expressions. There was a significant positive association between infant and parent attention to emotional expressions. Parental anxiety dispositions were not related to their own or their infant's attention bias. No significant link emerged between infants' temperament and attention bias. We conclude that an association between parental and infant attention may already be evident in the early years of life, whereas a link between anxiety dispositions and attention biases may not hold in community samples. |
Vladislav Ayzenberg; Stella Lourenco Perception of an object's global shape is best described by a model of skeletal structure in human infants Journal Article In: eLife, vol. 11, pp. 1–20, 2022. @article{Ayzenberg2022, Categorization of everyday objects requires that humans form representations of shape that are tolerant to variations among exemplars. Yet, how such invariant shape representations develop remains poorly understood. By comparing human infants (6–12 months; N=82) to computational models of vision using comparable procedures, we shed light on the origins and mechanisms underlying object perception. Following habituation to a never-before-seen object, infants classified other novel objects across variations in their component parts. Comparisons to several computational models of vision, including models of high-level and low-level vision, revealed that infants' performance was best described by a model of shape based on the skeletal structure. Interestingly, infants outperformed a range of artificial neural network models, selected for their massive object experience and biological plausibility, under the same conditions. Altogether, these findings suggest that robust representations of shape can be formed with little language or object experience by relying on the perceptually invariant skeletal structure. |
Anna Bánki; Martina Eccher; Lilith Falschlehner; Stefanie Hoehl; Gabriela Markova Comparing online webcam- and laboratory-based eye-tracking for the assessment of infants' audio-visual synchrony perception Journal Article In: Frontiers in Psychology, vol. 12, pp. 1–19, 2022. @article{Banki2022, Online data collection with infants raises special opportunities and challenges for developmental research. One of the most prevalent methods in infancy research is eye-tracking, which has been widely applied in laboratory settings to assess cognitive development. Technological advances now allow conducting eye-tracking online with various populations, including infants. However, the accuracy and reliability of online infant eye-tracking remain to be comprehensively evaluated. No research to date has directly compared webcam-based and in-lab eye-tracking data from infants, similarly to data from adults. The present study provides a direct comparison of in-lab and webcam-based eye-tracking data from infants who completed an identical looking time paradigm in two different settings (in the laboratory or online at home). We assessed 4-6-month-old infants (n = 38) in an eye-tracking task that measured the detection of audio-visual asynchrony. Webcam-based and in-lab eye-tracking data were compared on eye-tracking and video data quality, infants' viewing behavior, and experimental effects. Results revealed no differences between the in-lab and online setting in the frequency of technical issues and participant attrition rates. Video data quality was comparable between settings in terms of completeness and brightness, despite lower frame rate and resolution online. Eye-tracking data quality was higher in the laboratory than online, except in case of relative sample loss. Gaze data quantity recorded by eye-tracking was significantly lower than by video in both settings. In valid trials, eye-tracking and video data captured infants' viewing behavior uniformly, irrespective of setting. Despite the common challenges of infant eye-tracking across experimental settings, our results point toward the necessity to further improve the precision of online eye-tracking with infants. Taken together, online eye-tracking is a promising tool to assess infants' gaze behavior but requires careful data quality control. The demographic composition of both samples differed from the generic population on caregiver education: our samples comprised caregivers with higher-than-average education levels, challenging the notion that online studies will per se reach more diverse populations. |
Liam P. Blything; Maialen Iraola Azpiroz; Shanley Allen; Regina Hert; Juhani Järvikivi; Juhani Jarvikivi The influence of prominence cues in 7- to 10-year-olds' pronoun resolution: Disentangling order of mention, grammatical role, and semantic role Journal Article In: Journal of Child Language, vol. 49, no. 5, pp. 930–958, 2022. @article{Blything2022, In two visual world experiments we disentangled the influence of order of mention (first vs. second mention), grammatical role (subject vs object), and semantic role (proto-agent vs proto-patient) on 7- to 10-year-olds' real-time interpretation of German pronouns. Children listened to SVO or OVS sentences containing active accusative verbs (küssen "to kiss") in Experiment 1 (N = 72), or dative object-experiencer verbs (gefallen "to like") in Experiment 2 (N = 64). This was followed by the personal pronoun er or the demonstrative pronoun der. Interpretive preferences for er were most robust when high prominence cues (first mention, subject, proto-agent) were aligned onto the same entity; and the same applied to der for low prominence cues (second mention, object, proto-patient). These preferences were reduced in conditions where cues were misaligned, and there was evidence that each cue independently influenced performance. Crucially, individual variation in age predicted adult-like weighting preferences for semantic cues (Schumacher, Roberts & Järvikivi, 2017). |
Jonathan E. Prunty; Jolie R. Keemink; David J. Kelly Infants show pupil dilatory responses to happy and angry facial expressions Journal Article In: Developmental Science, vol. 25, no. 2, pp. 1–11, 2022. @article{Prunty2022, Facial expressions are one way in which infants and adults communicate emotion. Infants scan expressions similarly to adults, yet it remains unclear whether they are receptive to the affective information they convey. The current study investigates 6-, 9- and 12-month infants' (N = 146) pupillary responses to the six “basic” emotional expressions (happy, sad, surprise, fear, anger, and disgust). To do this we use dynamic stimuli and gaze-contingent eye-tracking to simulate brief interactive exchanges, alongside a static control condition. Infants' arousal responses were stronger for dynamic compared to static stimuli. And for dynamic stimuli we found that, compared to neutral, infants showed dilatory responses for happy and angry expressions only. Although previous work has shown infants can discriminate perceptually between facial expressions, our data suggest that sensitivity to the affective content of all six basic emotional expressions may not fully emerge until later in ontogeny. |
Tianying Qing; Ying Xiao; Huidong Xue; Wei Wang; Ming Ye; Jing Hu; Licheng Xue; Bing Chen; Yating Lv; Jing Zhao Development of attentional bias towards visual word forms in the environment in preschool children Journal Article In: Visual Cognition, vol. 30, no. 3, pp. 214–227, 2022. @article{Qing2022, Environmental prints (e.g., the name “Mcdonald's” on advertising boards) provide a visual environment rich in written words at the early stage of learning to read. Children's attention to words is closely related to the process of learning to read. However, what remains unclear is how children's attention to words in environmental prints develops and is related to their reading ability before conventional reading training begins. Using the eye-tracking technique, the present study examined the early development of attention to words in environmental prints. Four-, five-, and six-year-old preschool children were tested. We transformed the original format of each environmental print into three versions with gradually minimized contextual cues (i.e., colour, logo, and font type). The results showed that attentional bias towards words increases with age even before conventional reading training. Moreover, it appears that a rapid increase occurs between the ages of four and five. The logo cue (rather than colour cue or font type cue) has a salient effect on the attentional bias towards words. Attentional bias towards words is increased with children's reading ability. |
Emily B. Reilly; Kelli L. Dickerson; Lara J. Pierce; Jukka Leppänen; Viviane Valdes; Alma Gharib; Barbara L. Thompson; Lisa J. Schlueter; Pat Levitt; Charles A. Nelson Maternal stress and development of infant attention to threat-related facial expressions Journal Article In: Developmental Psychobiology, vol. 64, no. 7, pp. 1–12, 2022. @article{Reilly2022, Attentional biases to threat-related stimuli, such as fearful and angry facial expressions, are important to survival and emerge early in development. Infants demonstrate an attentional bias to fearful facial expressions by 5–7 months of age and an attentional bias toward anger by 3 years of age that are modulated by experiential factors. In a longitudinal study of 87 mother–infant dyads from families predominantly experiencing low income, we examined whether maternal stress and depressive symptoms were associated with trajectories of attentional biases to threat, assessed during an attention disengagement eye-tracking task when infants were 6-, 9-, and 12-month old. By 9 months, infants demonstrated a generalized bias toward threat (both fearful and angry facial expressions). Maternal perceived stress was associated with the trajectory of the bias toward angry facial expressions between 6 and 12 months. Specifically, infants of mothers with higher perceived stress exhibited a greater bias toward angry facial expressions at 6 months that decreased across the next 6 months, compared to infants of mothers with lower perceived stress who displayed an increased bias to angry facial expressions over this age range. Maternal depressive symptoms and stressful life events were not associated with trajectories of infant attentional bias to anger or fear. These findings highlight the role of maternal perceptions of stress in shaping developmental trajectories of threat-alerting systems. |
Tracy Reuter; Mia Sullivan; Casey Lew-Williams Look at that: Spatial deixis reveals experience-related differences in prediction Journal Article In: Language Acquisition, vol. 29, no. 1, pp. 1–26, 2022. @article{Reuter2022, Prediction-based theories posit that interlocutors use prediction to process language efficiently and to coordinate dialogue. The present study evaluated whether listeners can use spatial deixis (i.e., this, that, these, and those) to predict the plurality and proximity of a speaker's upcoming referent. In two eye-tracking experiments with varying referential complexity (N = 168), native English-speaking adults, native English-learning 5-year-olds, and nonnative English-learning adults viewed images while listening to sentences with or without informative deictic determiners, e.g., Look at the/this/that/these/those wonderful cookie(s). Results showed that all groups successfully exploited plurality information. However, they varied in using deixis to anticipate the proximity of the referent; specifically, L1 adults showed more robust prediction than L2 adults, and L1 children did not show evidence of prediction. By evaluating listeners with varied language experiences, this investigation helps refine proposed mechanisms of prediction and suggests that linguistic experience is key to the development of such mechanisms. |
Matthew K. Robison; Nathaniel T. Diede; Jessica Nicosia; B. Hunter Ball; Julie M. Bugg A multimodal analysis of sustained attention in younger and older adults Journal Article In: Psychology and Aging, vol. 37, no. 3, pp. 307–325, 2022. @article{Robison2022, Age-related cognitive decline has been attributed to processing speed differences, as well as differences in executive control and response inhibition. However, recent research has shown that healthy older adults have intact, if not superior, sustained attention abilities compared to younger adults. The present study used a combination of reaction time (RT), thought probes, and pupillometry to measure sustained attention in samples of younger and older adults. The RT data revealed that, while slightly slower overall, older adults sustained their attention to the task better than younger adults, and did not show a vigilance decrement. Older adults also reported fewer instances of task-unrelated thoughts and reported feeling more motivated and alert than younger adults, despite finding the task more demanding. Additionally, older adults showed larger, albeit laterpeaking, task-evoked pupillary responses (TEPRs), corroborating the behavioral and self-report data. Finally, older adults did not show a shallowing of TEPRs across time, corroborating the finding that their RTs also did not change across time. The present findings are interpreted in light of processing speed theory, resourcedepletion theories of vigilance, and recent neurological theories of cognitive aging. |
Kati Roesmann; Ida Wessing; Sophia Kraß; Elisabeth J. Leehr; Tim Klucken; Thomas Straube; Markus Junghöfer Developmental aspects of fear generalization – A MEG study on neurocognitive correlates in adolescents versus adults Journal Article In: Developmental Cognitive Neuroscience, vol. 58, pp. 1–12, 2022. @article{Roesmann2022, Background: Fear generalization is pivotal for the survival-promoting avoidance of potential danger, but, if too pronounced, it promotes pathological anxiety. Similar to adult patients with anxiety disorders, healthy children tend to show overgeneralized fear responses. Objective: This study aims to investigate neuro-developmental aspects of fear generalization in adolescence – a critical age for the development of anxiety disorders. Methods: We compared healthy adolescents (14–17 years) with healthy adults (19–34 years) regarding their fear responses towards tilted Gabor gratings (conditioned stimuli, CS; and slightly differently titled generalization stimuli, GS). In the conditioning phase, CS were paired (CS+) or remained unpaired (CS-) with an aversive stimulus (unconditioned stimuli, US). In the test phase, behavioral, peripheral and neural responses to CS and GS were captured by fear- and UCS expectancy ratings, a perceptual discrimination task, pupil dilation and source estimations of event-related magnetic fields. Results: Closely resembling adults, adolescents showed robust generalization gradients of fear ratings, pupil dilation, and estimated neural source activity. However, in the UCS expectancy ratings, adolescents revealed shallower generalization gradients indicating overgeneralization. Moreover, adolescents showed stronger visual cortical activity after as compared to before conditioning to all stimuli. Conclusion: Various aspects of fear learning and generalization appear to be mature in healthy adolescents. Yet, cognitive aspects might show a slower course of development. |
Shannon Ross-Sheehy; Bret Eschman; Esther E. Reynolds Seeing and looking: Evidence for developmental and stimulus-dependent changes in infant scanning efficiency Journal Article In: PLoS ONE, vol. 17, no. 9, pp. 1–24, 2022. @article{RossSheehy2022, Though previous work has examined infant attention across a variety of tasks, less is known about the individual saccades and fixations that make up each bout of attention, and how individual differences in saccade and fixation patterns (i.e., scanning efficiency) change with development, scene content and perceptual load. To address this, infants between the ages of 5 and 11 months were assessed longitudinally (Experiment 1) and cross-sectionally (Experiment 2). Scanning efficiency (fixation duration, saccade rate, saccade amplitude, and saccade velocity) was assessed while infants viewed six quasi-naturalistic scenes that varied in content (social or non-social) and scene complexity (3, 6 or 9 people/objects). Results from Experiment 1 revealed moderate to strong stability of individual differences in saccade rate, mean fixation duration, and saccade amplitude, and both experiments revealed 5-month-old infants to make larger, faster, and more frequent saccades than older infants. Scanning efficiency was assessed as the relation between fixation duration and saccade amplitude, and results revealed 11-month-olds to have high scanning efficiency across all scenes. However, scanning efficiency also varied with scene content, such that all infants showing higher scanning efficiency when viewing social scenes, and more complex scenes. These results suggest both developmental and stimulus-dependent changes in scanning efficiency, and further highlight the use of saccade and fixation metrics as a sensitive indicator of cognitive processing. |
Kelly C. Roth; Kenna R. H. Clayton; Greg D. Reynolds Infant selective attention to native and non-native audiovisual speech Journal Article In: Scientific Reports, vol. 12, no. 1, pp. 1–12, 2022. @article{Roth2022, The current study utilized eye-tracking to investigate the effects of intersensory redundancy and language on infant visual attention and detection of a change in prosody in audiovisual speech. Twelve-month-old monolingual English-learning infants viewed either synchronous (redundant) or asynchronous (non-redundant) presentations of a woman speaking in native or non-native speech. Halfway through each trial, the speaker changed prosody from infant-directed speech (IDS) to adult-directed speech (ADS) or vice versa. Infants focused more on the mouth of the speaker on IDS trials compared to ADS trials regardless of language or intersensory redundancy. Additionally, infants demonstrated greater detection of prosody changes from IDS speech to ADS speech in native speech. Planned comparisons indicated that infants detected prosody changes across a broader range of conditions during redundant stimulus presentations. These findings shed light on the influence of language and prosody on infant attention and highlight the complexity of audiovisual speech processing in infancy. |
Raheleh Saryazdi; Joanne Nuque; Craig G. Chambers Pragmatic inferences in aging and human-robot communication Journal Article In: Cognition, vol. 223, pp. 1–12, 2022. @article{Saryazdi2022a, Despite the increase in research on older adults' communicative behavior, little work has explored patterns of age-related change in pragmatic inferencing and how these patterns are adapted depending on the situation-specific context. In two eye-tracking experiments, participants followed instructions like “Click on the greenhouse”, which were either played over speakers or spoken live by a co-present robot partner. Implicit inferential processes were measured by exploring the extent to which listeners temporarily (mis)understood the unfolding noun to be a modified phrase referring to a competitor object in the display (green hat). This competitor was accompanied by either another member of the same category or an unrelated item (tan hat vs. dice). Experiment 1 (no robot) showed clear evidence of contrastive inferencing in both younger and older adults (more looks to the green hat when the tan hat was also present). Experiment 2 explored the ability to suppress these contrastive inferences when the robot talker was known to lack any color perception, making descriptions like “green hat” implausible. Younger but not older listeners were able to suppress contrastive inferences in this context, suggesting older adults could not keep the relevant limitations in mind and/or were more likely to spontaneously ascribe human attributes to the robot. Together, the findings enhance our understanding of pragmatic inferencing in aging. |
Karola Schlegelmilch; Annie E. Wertz Visual segmentation of complex naturalistic structures in an infant eye-tracking search task Journal Article In: PLoS ONE, vol. 17, no. 4, pp. 1–31, 2022. @article{Schlegelmilch2022, An infant's everyday visual environment is composed of a complex array of entities, some of which are well integrated into their surroundings. Although infants are already sensitive to some categories in their first year of life, it is not clear which visual information supports their detection of meaningful elements within naturalistic scenes. Here we investigated the impact of image characteristics on 8-month-olds' search performance using a gaze contingent eye-tracking search task. Infants had to detect a target patch on a background image. The stimuli consisted of images taken from three categories: vegetation, non-living natural elements (e.g., stones), and manmade artifacts, for which we also assessed target background differences in lower- and higher-level visual properties. Our results showed that larger target-background differences in the statistical properties scaling invariance and entropy, and also stimulus backgrounds including low pictorial depth, predicted better detection performance. Furthermore, category membership only affected search performance if supported by luminance contrast. Data from an adult comparison group also indicated that infants' search performance relied more on lower-order visual properties than adults. Taken together, these results suggest that infants use a combination of property- and category-related information to parse complex visual stimuli. |
Vladislava Segen; Marios N. Avraamides; Timothy J. Slattery; Jan M. Wiener Age-related changes in visual encoding strategy preferences during a spatial memory task Journal Article In: Psychological Research, vol. 86, no. 2, pp. 404–420, 2022. @article{Segen2022, Ageing is associated with declines in spatial memory, however, the source of these deficits remains unclear. Here we used eye-tracking to investigate age-related differences in spatial encoding strategies and the cognitive processes underlying the age-related deficits in spatial memory tasks. To do so we asked young and older participants to encode the locations of objects in a virtual room shown as a picture on a computer screen. The availability and utility of room-based landmarks were manipulated by removing landmarks, presenting identical landmarks rendering them uninformative, or by presenting unique landmarks that could be used to encode object locations. In the test phase, participants viewed a second picture of the same room taken from the same (0°) or a different perspective (30°) and judged whether the objects occupied the same or different locations in the room. We found that the introduction of a perspective shift and swapping of objects between encoding and testing impaired performance in both age groups. Furthermore, our results revealed that although older adults performed the task as well as younger participants, they relied on different visual encoding strategies to solve the task. Specifically, gaze analysis revealed that older adults showed a greater preference towards a more categorical encoding strategy in which they formed relationships between objects and landmarks. |
Elena Selezneva; Nicole Wetzel The impact of probabilistic cues on sound-related pupil dilation and ERP responses in 7–9-year-old children Journal Article In: Auditory Perception & Cognition, vol. 5, no. 1-2, pp. 86–106, 2022. @article{Selezneva2022, Control of involuntary orienting of attention toward new but task-irrelevant events is essential to successfully perform a task. We investigated top-down control of involuntary orienting of attention caused by task-irrelevant novel sounds embedded in a sequence of repeated standard sounds in 7–9-year-old children (N = 30) and in an adult control group (N = 30). The type of sound was announced by visual cues, which were correct in 80% of the trials. We co-registered sound-related pupil dilation responses (PDR), the attention-related component P3a in the EEG and performance. Task-irrelevant novel sounds evoked increased amplitudes of the PDR and the P3a and prolonged reaction times in both age groups. In children only, invalidly cued novel sounds evoked larger PDR amplitudes than validly cued novel sounds, while this cue effect was not observed for standard sounds. In both age groups, P3a amplitudes in the centro-parietal region were reduced to the correctly cued compared to the incorrectly cued novel sounds, indicating top-down control of orienting of attention. The reaction time prolongation to both validly and invalidly cued novel sounds were similar in both age groups. These findings demonstrate that children are capable of reducing the orienting of attention and evaluation triggered by task-irrelevant sounds by using probabilistic cues. Children's pupil results indicate a high sensitivity of pupil dynamics to cue-related top-down influences on novel sound processing, emphasizing the utility of pupillometry in developmental research. |
Adi Shechter; Ronen Hershman; David L. Share A pupillometric study of developmental and individual differences in cognitive effort in visual word recognition Journal Article In: Scientific Reports, vol. 12, no. 1, pp. 1–7, 2022. @article{Shechter2022, Throughout the history of modern psychology, the neural basis of cognitive performance, and particularly its efficiency, has been assumed to be an essential determinant of developmental and individual differences in a wide range of human behaviors. Here, we examine one aspect of cognitive efficiency—cognitive effort, using pupillometry to examine differences in word reading among adults (N = 34) and children (N = 34). The developmental analyses confirmed that children invested more effort in reading than adults, as indicated by larger and sustained pupillary responses. The within-age (individual difference) analyses comparing faster (N = 10) and slower (N = 10) performers revealed that in both age groups, the faster readers demonstrated accelerated pupillary responses compared to slower readers, although both groups invested a similar overall degree of cognitive effort. These findings have the potential to open up new avenues of research in the study of skill growth in word recognition and many other domains of skill learning. |
Frederick Shic; Adam J. Naples; Erin C. Barney; Shou An Chang; Beibin Li; Takumi McAllister; Minah Kim; Kelsey J. Dommer; Simone Hasselmo; Adham Atyabi; Quan Wang; Gerhard Helleman; April R. Levin; Helen Seow; Raphael Bernier; Katarzyna Charwaska; Geraldine Dawson; James Dziura; Susan Faja; Shafali Spurling Jeste; Scott P. Johnson; Michael Murias; Charles A. Nelson; Maura Sabatos-DeVito; Damla Senturk; Catherine A. Sugar; Sara J. Webb; James C. McPartland In: Molecular Autism, vol. 13, no. 1, pp. 1–17, 2022. @article{Shic2022, Background: Eye tracking (ET) is a powerful methodology for studying attentional processes through quantification of eye movements. The precision, usability, and cost-effectiveness of ET render it a promising platform for developing biomarkers for use in clinical trials for autism spectrum disorder (ASD). Methods: The autism biomarkers consortium for clinical trials conducted a multisite, observational study of 6–11-year-old children with ASD (n = 280) and typical development (TD |
Sabine Soltani; Dimitri M. L. Ryckeghem; Tine Vervoort; Lauren C. Heathcote; Keith O. Yeates; Christopher Sears; Melanie Noel Clinical relevance of attentional biases in pediatric chronic pain: An eye-tracking study Journal Article In: Pain, vol. 163, no. 2, pp. E261–E273, 2022. @article{Soltani2022, Attentional biases have been posited as one of the key mechanisms underlying the development and maintenance of chronic pain and co-occurring internalizing mental health symptoms. Despite this theoretical prominence, a comprehensive understanding of the nature of biased attentional processing in chronic pain and its relationship to theorized antecedents and clinical outcomes is lacking, particularly in youth. This study used eye-tracking to assess attentional bias for painful facial expressions and its relationship to theorized antecedents of chronic pain and clinical outcomes. Youth with chronic pain (n = 125) and without chronic pain (n = 52) viewed face images of varying levels of pain expressiveness while their eye gaze was tracked and recorded. At baseline, youth completed questionnaires to assess pain characteristics, theorized antecedents (pain catastrophizing, fear of pain, and anxiety sensitivity), and clinical outcomes (pain intensity, interference, anxiety, depression, and posttraumatic stress). For youth with chronic pain, clinical outcomes were reassessed at 3 months to assess for relationships with attentional bias while controlling for baseline symptoms. In both groups, youth exhibited an attentional bias for painful facial expressions. For youth with chronic pain, attentional bias was not significantly associated with theorized antecedents or clinical outcomes at baseline or 3-month follow-up. These findings call into question the posited relationships between attentional bias and clinical outcomes. Additional studies using more comprehensive and contextual paradigms for the assessment of attentional bias are required to clarify the ways in which such biases may manifest and relate to clinical outcomes. |
Krista R. Kelly; Dorsa Mir Norouzi; Mina Nouredanesh; Reed M. Jost; Christina S. Cheng-Patel; Cynthia L. Beauchamp; Lori M. Dao; Becky A. Luu; David R. Stager; James Y. Tung; Ewa Niechwiej-Szwedo Temporal eye–hand coordination during Visually guided reaching in 7- to 12-year-old children with strabismus Journal Article In: Investigative Ophthalmology & Visual Science, vol. 63, no. 12, pp. 1–10, 2022. @article{Kelly2022, PURPOSE. We recently found slow visually guided reaching in strabismic children, espe- cially in the final approach. Here, we expand on those data by reporting saccade kine- matics and temporal eye–hand coordination during visually guided reaching in children treated for strabismus compared with controls. METHODS. Thirty children diagnosed with esotropia, a form of strabismus, 7 to 12 years of age and 32 age-similar control children were enrolled. Eye movements and index finger movements were recorded. While viewing binocularly, children reached out and touched a small dot that appeared randomly in one of four locations along the horizontal peak velocity, and frequency of corrective and reach-related saccades) and temporal eye– meridian (±5° or ±10°). Saccade kinematic measures (latency, accuracy and precision, hand coordination measures (saccade-to-reach planning interval, saccade-to-reach peak velocity interval) were compared. Factors associated with impaired performance were also evaluated. RESULTS. During visually guided reaching, strabismic children had longer primary saccade latency (strabismic, 195 ± 29 ms vs. control; 175 ± 23 ms; P = 0.004), a 25% decrease in final saccade precision (0.16 ± 0.06 vs. 0.11 ± 0.03; P < 0.001), and more reach-related primary saccade precision (0.15 ± 0.06 vs. 0.12 ± 0.03; P= 0.007), a 45% decrease in the group. No measurable stereoacuity was related to poor saccade kinematics. saccades (16 ± 13% of trials vs. 8 ± 6% of trials; P = 0.001) compared with a control CONCLUSIONS. Strabismus impacts saccade kinematics during visually guided reaching in children, with poor binocularity playing a role in performance. Coupled with previous data showing slow reaching in the final approach, the current saccade data suggest that children treated for strabismus have not yet adapted or formed an efficient compensatory strategy during visually guided reaching. |